Microfluidics For Biohacking Hack Chat

July 5, 2021 by Dan Maloney 2 Comments

Join us on Wednesday, July 7 at noon Pacific for the Microfluidics for Biohacking Hack Chat with Krishna Sanka!

“Microfluidics” sounds like a weird and wonderful field, but one that doesn’t touch regular life too much. But consider that each time you fire up an ink-jet printer, you’re putting microfluidics to work, as nanoliter-sized droplets of ink are spewed across space to impact your paper at exactly the right spot.

Ink-jets may be mundane, but the principles behind them are anything but. Microfluidic mechanisms have found their way into all sorts of products and processes, with perhaps the most interesting uses being leveraged to explore and exploit the microscopic realms of life. Microfluidics can be used to recreate some of the nanoscale biochemical reactions that go on in cells, and offer not only new ways to observe the biological world, but often to manipulate it. Microfluidics devices range from “DNA chips” that can rapidly screen drug candidates against thousands of targets, to devices that can rapidly screen clinical samples for exposure to toxins or pathogens.

There are a host of applications of microfluidics in biohacking, and Krishna Sanka is actively working to integrate the two fields. As an engineering graduate student, his focus is open-source, DIY microfluidics that can help biohackers up their game, and he’ll stop by the Hack Chat to run us through the basics. Come with your questions about how — and why — to build your own microfluidics devices, and find out how modern biohackers are learning to “go with the flow.”

Our Hack Chats are live community events in the Hackaday.io Hack Chat group messaging. This week we’ll be sitting down on Wednesday, July 7 at 12:00 PM Pacific time. If time zones have you tied up, we have a handy time zone converter.

[Featured image: Cooksey/NIST]

DIY Neuroscience Hack Chat

February 22, 2021 by Dan Maloney 8 Comments

Join us on Wednesday, February 24 at noon Pacific for the DIY Neuroscience Hack Chat with Timothy Marzullo!

Watch a film about a mad scientist from the golden age of Hollywood and chances are good that among the other set pieces, you’ll see human brains floating in jars of cloudy fluid wired up to electrodes and fancy machines. It’s all made up, of course, but tropes work because they’re based on a kernel of truth, and we in the audience know that our brains and the other parts of our nervous system do indeed work on electricity. Or more precisely, excitable tissues in our nervous systems pass electrochemical signals between themselves as waves of potential across cell membranes.

Studying this electrical world locked away inside our heads is a challenging, but by no means impossible, pursuit. Usable signals can be picked up, amplified, digitized, and recorded to help us understand what’s going on when we think, feel, move, sleep, wake, or just be. Neuroscience has made tremendous strides looking at these signals, but the equipment to do so has largely remained the province of large universities and teaching hospitals with ample budgets, leaving the amateur neuroscientist out of luck.

Tim Marzullo, co-founder of Backyard Brains, is looking to change all that. While working on his Ph.D. in neuroscience at the University of Michigan, he and Greg Gage looked for ways to make the tools of neuroscience research affordable to everyone. The result is the Neuron SpikerBox, a low-cost bioamplifier that can tap into the “spikes” of action potential in live neurons. Open-source tools like these have helped educators bring neuroscience experiments to STEM students, and even helped other scientists set up novel, low-cost experiments.

Tim will join us on the Hack Chat to talk about doing DIY neuroscience and designing the instruments that make it possible. Bring your “mad scientist” questions as we push back the veil of ignorance on how our brains work, one neuron at a time.

Our Hack Chats are live community events in the Hackaday.io Hack Chat group messaging. This week we’ll be sitting down on Wednesday, February 24 at 12:00 PM Pacific time (UTC-8). If time zones have you tied up, we have a handy time zone converter.

Click that speech bubble to the right, and you’ll be taken directly to the Hack Chat group on Hackaday.io. You don’t have to wait until Wednesday; join whenever you want and you can see what the community is talking about.

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DVD Optics Power This Scanning Laser Microscope

February 2, 2021 by Dan Maloney 35 Comments

We’ve all likely seen the amazing images possible with a scanning electron microscope. An SEM can yield remarkably detailed 3D images of the tiniest structures, and they can be invaluable tools for research. But blasting high-energy cathode rays onto metal-coated samples in the vacuum chamber of a bulky and expensive instrument isn’t the only way to make useful images, as this home-brew laser scanning microscope demonstrates.

This one comes to us by way of [GaudiLabs], a Swiss outfit devoted to open-source lab equipment that enables citizen science; we saw their pocket-sized thermal cycler for PCR a while back. The basic scheme here is known as confocal laser scanning fluorescence microscopy, where a laser at one wavelength excites fluorescent tags bound to structures in a sample. Light emitted by the tags is collected, and a 3D image is built up from multiple scans of the sample at different focal planes.

Like many DIY projects, this microscope is built from old DVD parts, specifically the pickup heads. The precision optics in these commonly available assemblies, which are good enough to read pits as small as 150 nm on a Blu-Ray DVD, are well-suited for resolving similarly sized microstructures. One DVD pickup is used to scan the laser in the X-axis, while the other head is modified to carry the sample and move it in the Y-axis. The pickup head coils and laser are driven by an Arduino carried on a custom PCB along with the DVD heads. Complete build files are posted on GitHub for anyone interested in recreating this work.

We love tips like this that dig back a bit and find things we missed the first go-around. And the equipment [GaudiLabs] lists really has potential for the budding biohacker, which we also like.

Thanks for the tip on this one, [Bill].

Tracking Vaccination History With Invisible Tattoos

January 3, 2020 by Sharon Lin 57 Comments

Nowadays, we still rely on medical records to tell when our last vaccinations were. For social workers in developing countries, it’s an incredibly difficult task especially if there isn’t a good standard in place for tracking vaccinations already.

A team at the Massachusetts Institute of Technology may be providing a solution – they’ve developed a safe ink to be embedded into the skin alongside the vaccine, only visible under a special light provided by a smartphone camera app. It’s an inconspicuous way to document the patient’s vaccination history directly into their skin and low-risk enough to massively simplify the process of maintaining medical records for vaccines.

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Hacking Diabetes Hack Chat

October 14, 2019 by Dan Maloney 2 Comments

Join us on Wednesday, October 16 at noon Pacific for the Hacking Diabetes Hack Chat with Dana Lewis!

When your child is newly diagnosed with Type 1 diabetes (T1D), everyone is quick to point out, “It’s a great time to be a diabetic.” To some degree, that’s true; thanks to genetically engineered insulin, more frequent or even continuous glucose monitoring (CGM), and insulin infusion pumps, diabetics can now avoid many of the truly terrifying complications of a life lived with chronically elevated blood glucose, like heart disease, kidney failure, blindness, and amputations.

Despite these advances, managing T1D can be an overwhelming task. Every bite of food, every minute of exercise, and every metabolic challenge has to be factored into the calculations for how much insulin to take. Diabetics learn to “think like a pancreas,” but it’s never good enough, and the long-promised day of a true artificial pancreas always seems to remain five years in the future.

Dana Lewis is one diabetic who decided not to wait. After realizing that she could get data from her CGM, she built a system to allow friends and family to monitor her blood glucose readings remotely. With the addition of a Raspberry Pi and some predictive algorithms, she later built an open-source artificial pancreas, which she uses every day. And now she’s helping others take control of their diabetes and build their own devices through OpenAPS.org.

Join us on the Hack Chat as Dana drops by to discuss OpenAPS and her artificial pancreas. We’ll find out what her background is – spoiler alert: she wasn’t a hacker when she started this – what challenges she faced, the state of the OpenAPS project, and where she sees the artificial pancreas going.

Our Hack Chats are live community events in the Hackaday.io Hack Chat group messaging. This week we’ll be sitting down on Wednesday, October 16 at 12:00 PM Pacific time. If time zones have got you down, we have a handy time zone converter.

[Dana Lewis image source: GeekWire]

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Pegleg: Raspberry Pi Implanted Below The Skin (Not Coming To A Store Near You)

August 29, 2019 by Brian McEvoy 87 Comments

Earlier this month, a group of biohackers installed two Rasberry Pis in their legs. While that sounds like the bleeding edge, those computers were already v2 of a project called PegLeg. I was fortunate enough to see both versions in the flesh, so to speak. The first version was scarily large — a mainboard donated by a wifi router roughly the size of an Altoids tin. It’s a reminder that the line between technology’s cutting edge and bleeding edge is moving ever onward and this one was firmly on the bleeding edge.

How does that line end up moving? Sometimes it’s just a matter of what intelligent people can accomplish in a long week. Back in May, during a three-day biohacker convention called Grindfest, someone said something along the lines of, “Wouldn’t it be cool if…” Anyone who has spent an hour in a maker space or hacker convention knows how those conversations go. Rather than ending with a laugh, things progressed at a fever pitch.

The router shed all non-vital components. USB ports: ground off. Plastic case: recycled. Battery: repurposed. Amazon’s fastest delivery brought a Qi wireless coil to power the implant from outside the body and the smallest USB stick with 64 GB on the silicon. The only recipient of PegLeg version 1.0 was [Lepht Anonym], who uses the pronoun ‘it’. [Lepht] has a well-earned reputation among biohackers who focus on technological implants who often use the term “grinder,” not to be confused with the dating app or power tool.

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Biological Hacking In The 19th Century Or How The World Almost Lost Wine

June 3, 2019 by Al Williams 24 Comments

While it isn’t quite universal, a lot of people enjoy a glass of wine now and again. But the world faced a crisis in the 1800s that almost destroyed some of the world’s great wines. Science — or some might say hacking — saved the day, even though it isn’t well known outside of serious oenophiles. You might wonder how biological hacking occurred in the 19th century. It did. It wasn’t as fast or efficient, but fortunately for wine drinkers, it got the job done.

When people tell me about new cybersecurity threats, I usually point out that cybercrime isn’t new. People have been stealing money, tricking people into actions, and impersonating other people for centuries. The computer just makes it easier. Even computing itself isn’t a new idea. Counting on your fingers and counting with electrons is just a matter of degree. Surely, though, mashing up biology is a more recent scientific advancement, right? While it is true that CRISPR can make editing genes a weekend garage project, people have been changing the biology of plants and animals for centuries using techniques like selective breeding and grafting. Not as effective, but sometimes effective enough.

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