Synthesizing Daraprim To Beat Price Gougers

September 11, 2017 by Lewin Day 35 Comments

Drugs are used the world over to treat disease. However, from time to time, the vagaries of market economics, or unscrupulous action, can radically increase the price of otherwise cheap pharmaceuticals far beyond the reach of the average person. This was the case with Pyrimethamine (sold as Daraprim), which is used to treat toxoplasmosis and malaria, among other users. With the price skyrocketing from $13 to $750 a tablet in the US in 2015, [NurdRage] decided to synthesize the drug on their own. (If you missed the background hubbub, search for “Martin Shkreli”.)

The video linked covers the final synthesis, though [NurdRage] has previously covered the synthesis of the required precursor chemicals. Budding chemists may grow excited, but there are significant hurdles to attempting this synthesis yourself. Chemicals involved are carcinogenic, toxic, acidic, or otherwise dangerous, and a fume hood is a necessity if working inside. Outside of this, there are immense risks in homebrewing pharmaceuticals. Performing the synthesis of an important drug is one thing, but to do so at a medical-grade level where the products are safe for human consumption is on an entirely different level.

Overall, [NurdRage] has put out a series of videos that have strong educational value, showing us what really goes into the production of a common pharmaceutical compound. There’s also something to be said about taking the production of life-saving medicines into one’s own hands in the face of prohibitive treatment costs. In a similar vein, perhaps you’ve considered producing your own insulin in an emergency?

[Thanks to jwrm22 for the tip]

The Things Network Sets 702 Km Distance Record For LoRaWAN

September 11, 2017 by Jenny List 17 Comments

Many of us will have at some time over the last couple of years bought a LoRaWAN module or two to evaluate the low power freely accessible wireless networking technology. Some have produced exciting and innovative projects using them while maybe the rest of us still have them on our benches as reminders of projects half-completed.

If your LoRaWAN deployment made it on-air, you’ll be familiar with the range that can be expected. A mile or two with little omnidirectional antennas if you are lucky. A few more miles if you reach for something with a bit of directionality. Add some elevation, and range increases.

A couple of weeks ago at an alternative society festival in the Netherlands, a balloon was launched with a LoRaWAN payload on board that was later found to have made what is believed to be a new distance record for successful reception of a LoRaWAN packet. While the balloon was at an altitude of 38.772 km (about 127204.7 feet) somewhere close to the border between Germany and the Netherlands, it was spotted by a The Things Network node in Wroclaw, Poland, at a distance of 702.676km, or about 436 miles. The Things Network is an open source, community driven effort that has built a worldwide LoRaWAN network.

Of course, a free-space distance record for a balloon near the edge of space might sound very cool and all that, but it’s not going to be of much relevance when you are wrestling with the challenge of getting sensor data through suburbia. But it does provide an interesting demonstration of the capabilities of LoRaWAN over some other similar technologies, if a 25mW (14dBm) transmitter can successfully send a packet over that distance then perhaps it might be your best choice in the urban jungle.

If you’re curious about LoRaWAN, you might want to start closer to home and sniff for local activity.

The Components Are INSIDE The Circuit Board

September 11, 2017 by Bob Baddeley 56 Comments

Through-hole assembly means bending leads on components and putting the leads through holes in the circuit board, then soldering them in place, and trimming the wires. That took up too much space and assembly time and labor, so the next step was surface mount, in which components are placed on top of the circuit board and then solder paste melts and solders the parts together. This made assembly much faster and cheaper and smaller.

Now we have embedded components, where in order to save even more, the components are embedded inside the circuit board itself. While this is not yet a technology that is available (or probably even desirable) for the Hackaday community, reading about it made my “holy cow!” hairs tingle, so here’s more on a new technology that has recently reached an availability level that more and more companies are finding acceptable, and a bit on some usable design techniques for saving space and components.

Continue reading “The Components Are INSIDE The Circuit Board” →

These Twenty Assistive Technologies Projects Won $1000 In The Hackaday Prize

September 11, 2017 by Brian Benchoff 3 Comments

Today, we’re excited to announce the winners of the Assistive Technologies portion of The Hackaday Prize. In this round, we’re looking for projects that will help ensure a better quality of life for the disabled. Whether this is something that enhances learning, working, or daily living. These are the projects that turn ‘disability’ into ‘this ability’.

Hackaday is currently hosting the greatest hardware competition on Earth. We’re giving away hundreds of thousands of dollars to hardware creators to build the next great thing. Last week, we wrapped up the fourth of five challenges. It was all about showing a design to Build Something That Matters. Hundreds entered and began their quest to build a device to change the world.

There’s still one entry challenge remaining in The Hackaday Prize. Anything Goes is on right now and open to every idea imaginable. If you’re building a computer made of sand, awesome. Quadcopter hammock? Neat. This is the portion of the Hackaday Prize that’s open to the best ideas out there. It’s up to you to explain how your creation makes the world a little bit better place.

The winners of the Assistive Technologies challenge are, in no particular order:

Assistive Technologies Hackaday Prize Finalists:

Continue reading “These Twenty Assistive Technologies Projects Won $1000 In The Hackaday Prize” →

Hack Space Debris At Your Peril

September 11, 2017 by Steven Dufresne 41 Comments

Who has dibs on space debris? If getting to it were a solved problem, it sure would be fun to use dead orbital hardware as something of a hacker’s junk bin. Turns out there is some precedent for this, and regulations already in place in the international community.

To get you into the right frame of mind: it’s once again 2100 AD and hackers are living in mile-long space habitats in the Earth-Moon system. But from where do those hackers get their raw material, their hardware? The system abounds with space debris, defunct satellites from a century of technological progress. According to Earth maritime law, if space is to be treated like international waters then the right of salvage would permit them to take parts from any derelict. But is space like international waters? Or would hacking space debris result in doing hard time in the ice mines of Ceres?

Continue reading “Hack Space Debris At Your Peril” →

If You’re Going To Make A Model Engine, You Might As Well Make It A Merlin

September 11, 2017 by Jenny List 42 Comments

It has been remarked before in more than one Hackaday post, that here are many communities like our own that exist in isolation and contain within them an astonishing level of hardware and engineering ability. We simply don’t see all the work done by the more engineering-driven and less accessory-driven end of the car modification scene, for example, because by and large we do not move in the same circles as them.

One such community in which projects displaying incredible levels of skill are the norm is the model making world. We may all have glued together a plastic kit of a Spitfire or a Mustang in our youth, but at the opposite end of the dial when it comes to models you will find craftsmanship that goes well beyond that you’d find in many high-end machine shops.

A project that demonstrates this in spades is [mayhugh1]’s quarter-scale model of a vintage Rolls-Royce Merlin V12 piston aero engine. This was the power plant that you would have found in many iconic Allied aircraft of the WW2 era, including the real-life Spitfires and all but the earliest of those Mustangs. And what makes the quarter-scale Merlin just that little bit more special, is that it runs. Just add fuel.

The build took place over a few years and many pages of a forum thread, and includes multiple blow-by-blow accounts, photos, and videos. It started with a set of commercial castings for the engine block, but their finishing and the manufacture of all other engine parts is done in the shop. In the final page or so we see the video we’ve placed below the break, of the finished engine in a test frame being run up on the bench, with a somewhat frightening unguarded airscrew attached to its front and waiting to decapitate an unwary cameraman. Sit down with a cup of your favourite beverage, and read the build from start to finish. We don’t think you’ll be disappointed.

Continue reading “If You’re Going To Make A Model Engine, You Might As Well Make It A Merlin” →

Hackaday London Meet-up This Friday

September 11, 2017 by Mike Szczys 12 Comments

Hackaday takes over London at the end of this week. Join us on Friday night as we host a meetup at the Marquis Cornwallis, a pub in Bloomsbury.

This is a Bring-a-Hack style meetup, so grab something you’ve been working on to get the conversation flowing as you enjoy food and drink with members of the Hackaday community from the area. Also on hand from the Hackaday Crew will be [Mike Szczys], [Elliot Williams], [Jenny List], [Pedro Umbelino], and [Adil Malik]. We’re consistently delighted by the many and varied projects that show up — we want to meet you and hear about your project no matter how trivial, or involved. We do suggest you bring something handheld though, as tabletop space will be limited.

We’ve rented the upper floor of the pub and ordered food and fine beverages for all who attend. This is possible thanks to the support of DesignSpark, the exclusive sponsor of the Hackaday UK Unconference.

Tickets for that event have been sold out for ages now, so we’re glad to host a meetup to involve more of the UK Hackaday community. There are still a few left for this Friday Meetup so claim your free ticket now!