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Regenerative Medicine: The Promise Of Undoing The Ravages Of Time

January 12, 2022 by 15 Comments

In many ways, the human body is like any other machine in that it requires constant refueling and maintenance to keep functioning. Much of this happens without our intervention beyond us selecting what to eat that day. There are however times when due to an accident, physical illness or aging the automatic repair mechanisms of our body become overwhelmed, fail to do their task correctly, or outright fall short in repairing damage.

Most of us know that lizards can regrow tails, some starfish regenerate into as many new starfish as the pieces which they were chopped into, and axolotl can regenerate limbs and even parts of their brain. Yet humans too have an amazing regenerating ability, although for us it is mostly contained within the liver, which can regenerate even when three-quarters are removed.

In the field of regenerative medicine, the goal is to either induce regeneration in damaged tissues, or to replace damaged organs and tissues with externally grown ones, using the patient’s own genetic material. This could offer us a future in which replacement organs are always available at demand, and many types of injuries are no longer permanent, including paralysis. Continue reading “Regenerative Medicine: The Promise Of Undoing The Ravages Of Time” →

Haber-Bosch And The Greening Of Ammonia Production

January 11, 2022 by 47 Comments

We here on Earth live at the bottom of an ocean of nitrogen. Nearly 80% of every breath we take is nitrogen, and the element is a vital component of the building blocks of life. Nitrogen is critical to the backbone of proteins that form the scaffold that life hangs on and that catalyze the myriad reactions in our cells, and the information needed to build these biopolymers is encoded in nucleic acids, themselves nitrogen-rich molecules.

And yet, in its abundant gaseous form, nitrogen remains directly unavailable to higher life forms, unusably inert and unreactive. We must steal our vital supply of nitrogen from the few species that have learned the biochemical trick of turning atmospheric nitrogen into more reactive compounds like ammonia. Or at least until relatively recently, when a couple of particularly clever members of our species found a way to pull nitrogen from the air using a combination of chemistry and engineering now known as the Haber-Bosch process.

Haber-Bosch has been wildly successful, and thanks to the crops fertilized with its nitrogenous output, is directly responsible for growing the population from a billion people in 1900 to almost eight billion people today. Fully 50% of the nitrogen in your body right now probably came from a Haber-Bosch reactor somewhere, so we all quite literally depend on it for our lives. As miraculous as Haber-Bosch is, though, it’s not without its problems, particularly in this age of dwindling supplies of the fossil fuels needed to run it. Here, we’ll take a deep dive into Haber-Bosch, and we’ll also take a look at ways to potentially decarbonize our nitrogen fixation industry in the future.

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Open 3D Engine editor with Amazon Shader Language file and asset from the game Deadhaus Sonata open. (Credit: O3DE project)

Open 3D Engine: Amazon’s Old Clothes Or A Game Engine To Truly Get Excited About?

January 10, 2022 by 14 Comments

Recently Amazon announced that they would be open sourcing the 3D engine and related behind their Amazon Lumberyard game tooling effort. As Lumberyard is based on CryEngine 3.8  (~2015 vintage), this raises the question of whether this new open source engine – creatively named Open 3D Engine (O3DE) – is an open source version of a CryTek engine, and what this brings to those of us who like to tinker with 2D, 3D games and similar.

When reading through the marketing materials, one might be forgiven for thinking that O3DE is the best thing since sliced 3D bread, and is Amazon’s benevolent gift to the unwashed masses to free them from the chains imposed on them by proprietary engines like Unity and Unreal Engine. A closer look reveals however that O3DE is Lumberyard, but with many parts of Lumberyard replaced, including the renderer still in the process of being rewritten from the old CryEngine code.

What Makes a Good Game Engine?

My own game development attempts started with the Half Life engine and the Valve Hammer editor, as well as the Doom map editor. This meant that some expectations were set before encountering today’s game engines and their tools. The development experience with the Hammer editor in the late 1990s was pretty much WYSIWYG, and when I was just getting started with Unreal Engine 4 (UE4) a number of years back this was pretty much the same experience, making it relatively easy to hit the ground running. Continue reading “Open 3D Engine: Amazon’s Old Clothes Or A Game Engine To Truly Get Excited About?” →

Books You Should Read: The Perfectionists

January 7, 2022 by 28 Comments
After pulling late hours in my school machine shop for a few years, I couldn’t help but wonder, who measures the measurement tools? How did they come to be? I’d heard anecdotes from other students and engineers while they inspected my freshly machined parts, but these stories were one-offs. What I wanted was a tale of industrial precision from start to finish. Years later, I found it.

The story of precision, as told by Simon Winchester, is captured in The Perfectionists: How Precision Engineers Created the Modern World. Published in 2018, Winchester’s overview stretches as far back to the Antikythera mechanism and brings us to present day silicon wafer manufacturing. Of course, this isn’t a chronology of all-things made precisely. Instead, it’s a romp through engineering highlights that hallmark either a certain level of precision manufacturing or a particular way of thinking with repercussions for the future. Continue reading “Books You Should Read: The Perfectionists” →

2021: As The Hardware World Turns

January 3, 2022 by 15 Comments

Well, that didn’t go quite as we expected, did it? Wind the clock back 365 days, and the world seemed to be breathing a collective sigh of relief after making it through 2020 in one piece. Folks started getting their COVID-19 vaccines, and in-person events started tentatively putting new dates on the calendar. After a rough year, it seemed like there was finally some light at the end of the tunnel.

Turns out, it was just a another train. New variants of everyone’s favorite acute respiratory syndrome have kept the pandemic rolling, and in many parts of the world, the last month or so has seen more new cases of the virus than at any point during 2020. This is the part of the Twilight Zone episode were we realize that not only have we not escaped the danger, we didn’t even understand the scope of it to begin with.

Case in point, the chip shortages. We can’t blame it entirely on the pandemic, but it certainly hasn’t helped matters. From video game systems to cars, production has crawled to a standstill as manufacturers fight to get their hands on integrated circuits that were once plentiful. It’s not just a problem for industry either, things have gotten so bad that there’s a good chance most of the people reading this have found themselves unable to get their hands on a part or two these last few months. If you were working on a hobby project, it’s a temporary annoyance. But for those who planned on finally bringing their latest big idea to market, we’ve heard tales of heartbreaking delays and costly redesigns.

It would be easy to look at the last twelve months and see nothing but disappointment, but that’s hardly the attitude you want to have at the beginning of the year. So let’s take the high road, and look back on some of the highlights from 2021 as we turn a hopeful eye towards the future.

Continue reading “2021: As The Hardware World Turns” →

Plastics: Photopolymers For 3D Printing And Beyond

December 21, 2021 by 9 Comments

Chances are good that if you’ve done any 3D printing, it was of the standard fused deposition modeling variety. FDM is pretty simple stuff — get a bit of plastic filament hot enough, squeeze the molten goo out of a fine nozzle, control the position of the nozzle more or less precisely in three dimensions, and repeat for hours on end until your print is done. To the outsider it looks like magic, but to us it’s just another Saturday afternoon.

Resin printing is another thing altogether, and a lot closer to magic for most of us. The current crop of stereolithography printers just have a high-resolution LCD display between a UV light source and a build tank with a transparent bottom. Prints are built up layer by layer by flashing UV light patterns into the tank as a build plate slowly lifts it up from the resin, like some creature emerging from the primordial goo.

Of course it’s all just science, but if there is any magic in SLA printing, surely it’s in the resins used for it. Their nondescript brown plastic bottles and information-poor labels give little clue as to their ingredients, although their hydrocarbon reek and viscous, sticky texture are pretty good clues. Let’s take a look inside the resin bottle and find out what it is that makes the magic of SLA happen.

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The Real Science (Not Armchair Science) Of Consciousness

December 15, 2021 by 43 Comments

Among brain researchers there’s a truism that says the reason people underestimate how much unconscious processing goes on in your brain is because you’re not conscious of it. And while there is a lot of unconscious processing, the truism also points out a duality: your brain does both processing that leads to consciousness and processing that does not. As you’ll see below, this duality has opened up a scientific approach to studying consciousness.

Are Subjective Results Scientific?

Researcher checking fMRI images.
Checking fMRI images.

In science we’re used to empirical test results, measurements made in a way that are verifiable, a reading from a calibrated meter where that reading can be made again and again by different people. But what if all you have to go on is what a person says they are experiencing, a subjective observation? That doesn’t sound very scientific.

That lack of non-subjective evidence is a big part of what stalled scientific research into consciousness for many years. But consciousness is unique. While we have measuring tools for observing brain activity, how do you know whether that activity is contributing to a conscious experience or is unconscious? The only way is to ask the person whose brain you’re measuring. Are they conscious of an image being presented to them? If not, then it’s being processed unconsciously. You have to ask them, and their response is, naturally, subjective.

Skepticism about subjective results along with a lack of tools, held back scientific research into consciousness for many years. It was taboo to even use the C-word until the 1980s when researchers decided that subjective results were okay. Since then, here’s been a great deal of scientific research into consciousness and this then is a sampling of that research. And as you’ll see, it’s even saved a life or two.

Continue reading “The Real Science (Not Armchair Science) Of Consciousness” →