Little Pharma On The Prairie

September 24, 2024 by Brian McEvoy 53 Comments

Let’s get the obvious out of the way first — in his DEFCON 32 presentation, [Dr. Mixæl Laufer] shared quite a bit of information on how individuals can make and distribute various controlled substances. This cuts out pharmaceutical makers, who have a history of price-gouging and discontinuing recipes that hurt their bottom line. We predict that the comment section will be incendiary, so if your best argument is, “People are going to make bad drugs, so no one should get to have this,” please disconnect your keyboard now. You would not like the responses anyway.

Let’s talk about the device instead of policy because this is an article about an incredible machine that a team of hackers made on their own time and dime. The reactor is a motorized mixing vessel made from a couple of nested Mason jars, surrounded by a water layer fed by hot and cold reservoirs and cycled with water pumps. Your ingredients come from three syringes and three stepper-motor pumps for accurate control. The brains reside inside a printable case with a touchscreen for programming, interaction, and alerts.

It costs around $300 USD to build a MicroLab, and to keep it as accessible as possible, it can be assembled without soldering. Most of the cost goes to a Raspberry Pi and three peristaltic pumps, but if you shop around for the rest of the parts, you can deflate that price tag significantly. The steps are logical, broken up like book chapters, and have many clear pictures and diagrams. If you want to get fancy, there is room to improvise and personalize. We saw many opportunities where someone could swap out components, like power supplies, for something they had lying in a bin or forego the 3D printing for laser-cut boards. The printed pump holders spell “HACK” when you disassemble them, but we would have gone with extruded aluminum to save on filament.

Several times [⁨Mixæl] brings up the point that you do not have to be a chemist to operate this any more than you have to be a mechanic to drive a car. Some of us learned about SMILES (Simplified Molecular Input Line Entry System) from this video, and with that elementary level of chemistry, we feel confident that we could follow a recipe, but maybe for something simple first. We would love to see a starter recipe that combines three sodas at precise ratios to form a color that matches a color swatch, so we know the machine is working correctly; a “calibration cocktail,” if you will.

If you want something else to tickle your chemistry itch, check out our Big Chemistry series or learn how big labs do automated chemistry.

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What Can We Do With These Patient Monitor Videos?

August 7, 2023 by Tom Nardi 22 Comments

So we’ll admit from the start that we’re not entirely sure how the average Hackaday reader can put this content to use. Still, these simulated patient monitor videos on YouTube gotta be useful for something. Right?

Uploaded by [themonitorsolution], each fourteen-minute 1080p video depicts what a patient monitor would look like in various situations, ranging from an adult in stable condition to individuals suffering from ailments such as COPD and sepsis. There’s even one for a dead patient, which makes for rather morbid watching.

Now we assume these are intended for educational purposes — throw them up on a display and have trainees attempt to diagnose what’s wrong with the virtual patient. But we’re sure clever folks like yourselves could figure out alternate uses for these realistic graphics. They could make for an impressive Halloween prop, or maybe they are just what you need to get that low-budget medical drama off the ground, finally.

Honestly, it seemed too cool of a resource not to point out. Besides, it’s exceedingly rare that we get to post a YouTube video that we can be confident none of our readers have seen before…at the time of this writing, the channel only has a single subscriber. Though with our luck, that person will end up being one of you lot.

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Blood Pressure Monitor For Under $1

June 20, 2023 by Bryan Cockfield 22 Comments

Medical equipment is not generally known for being inexpensive, with various imaging systems usually weighing in at over a million dollars, and even relatively simpler pieces of technology like digital thermometers, stethoscopes, and pulse oximeters coming in somewhere around $50. As the general pace of technological improvement continues on we expect marginal decreases in costs, but every now and then a revolutionary piece of technology will drop the cost of something like a blood pressure monitor by over an order of magnitude.

Typically a blood pressure monitor involves a cuff that pressurizes against a patient’s arm, and measures the physical pressure of the blood as the heart forces blood through the area restricted by the cuff. But there are some ways to measure blood pressure by proxy, instead of directly. This device, a small piece of plastic with a cost of less than a dollar, attaches to a smartphone near the camera sensor and flashlight. By pressing a finger onto the device, the smartphone uses the flashlight and the camera in tandem to measure subtle changes in the skin, which can be processed in an app to approximate blood pressure.

The developers of this technology note that it’s not a one-to-one substitute for a traditional blood pressure monitor, but it is extremely helpful for those who might not be able to afford a normal monitor and who might otherwise go undiagnosed for high blood pressure. Almost half of adults in the US alone have issues relating to blood pressure, so just getting information at all is the hurdle this device is attempting to overcome. And, we’ll count it as a win any time medical technology becomes more accessible, more inexpensive, or more open-source.

A Crash Course On How MRI Machines Work

May 11, 2023 by Dave Rowntree 32 Comments

Of all the high-tech medical gadgets we read about often, the Magnetic Resonance Imaging (MRI) machine is possibly the most mysterious of all. The ability to peer inside a living body, in a minimally invasive manner whilst differentiating tissue types, in near real-time was the stuff of science fiction not too many years ago. Now it’s commonplace. But how does the machine actually work? Real Engineering on YouTube presents the Insane Engineering of MRI Machines to help us along this learning curve, at least in a little way.

Both types of gradient coil are stacked around the subject inside the main field coil

The basic principle of operation is to align the spin ‘axis’ of all the subject’s hydrogen nuclei using an enormous magnetic field produced by a liquid-helium-cooled superconducting electromagnet. The spins are then perturbed with a carefully tuned radio frequency pulse delivered via a large drive coil.

After a short time, the spins revert back to align with the magnetic field, remitting a radio pulse at the same frequency. Every single hydrogen nucleus (just a proton!) responds at roughly the same time, with the combined signal being detected by the receive coil (often the same physical coil as the driver.)

Time taken for the perturbed spin to return to magnetic alignment

There are two main issues to solve. Obviously, the whole body section is ‘transmitting’ this radio signal all in one big pulse, so how do you identify the different areas of 3D space (i.e. the different body structures) and how do you differentiate (referred to as contrast) different tissue types, such as determine if something is bone or fat?

By looking at the decay envelope of the return pulse, two separate measures with different periods can be determined; T1, the spin relaxation period, and T2, the total spin relaxation period. The first one is a measure of how long it takes the spin to realign, and the second measures the total period needed for all the individual interactions between different atoms in the subject to settle down. The values of T1 and T2 are programmed into the machine to adjust the pulse rate and observation time to favor the detection of one or the other effect, effectively selecting the type of tissue to be resolved.

Time taken for the relative phasing inside a tissue locality to settle down to the same average spin alignment

The second issue is more complex. Spatial resolution is achieved by first selecting a plane to virtually slice the body into a 2D image. Because the frequency of the RF pulse needed to knock the proton spin out of alignment is dependent upon the magnetic field strength, overlaying a second magnetic field via a gradient coil allows the local magnetic field to be tuned along the axis of the machine and with a corresponding tweak to the RF frequency an entire body slice can be selected.

All RF emissions from the subject emanate from just the selected slice reducing the 3D resolution problem to a 2D problem. Finally, a similar trick is applied orthogonally, with another set of gradient coils that adjust the relative phase of the spins of stripes of atoms through the slice. This enables the use of a 2D inverse Fourier transform of multiple phase and frequency combinations to image the slice from every angle, and a 2D image of the subject can then be reconstructed and sent to the display computer for the operator to observe.

See? It’s easy.

We cover MRI technology from time to time, here’s a little update on state-of-the-art resolution for those wishing the dig a little deeper.

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USB Borescope Lets Doctors Hone Intubation Skills On The Cheap

April 30, 2023 by Dan Maloney 8 Comments

One of the most critical skills in emergency medicine is airway management. Without a patent airway, a patient has about four minutes to live, so doctors and paramedics put a huge amount of effort into honing their intubation skills. They have to be able to insert an endotracheal tube quickly and efficiently, without damaging sensitive structures like the vocal cords. It’s a tricky skill to master without a ton of practice.

The perfect tool to practice these skills is a video laryngoscope, but these are wildly expensive and reserved for clinical use. Luckily, with a little ingenuity and a cheap USB borescope, [Dr. Adam Blumenberg] and [Dr. Erin Falk] were able to come up with this low-cost video-assisted laryngoscopy setup to reach as many students as possible. The idea is to use a single-use laryngoscope blade, which replicates the usual tool used to visualize the patient’s vocal cords. The blade is made from clear plastic, which makes it perfect for the application. The borescope is passed through an opening in the blade and affixed to it with adhesives. A little Dremel work might be necessary to get the optical axes of the blade and the camera to line up; failing that, there’s always the option to disassemble the camera to get a better angle.

The chief advantage of this setup, aside from being cheap, is that it’s something that it’s not intended to be used on patients. Along with an airway manikin, the tricked-out borescope can sit in a conference room waiting for students to have a go. Using a large screen allows the whole group to watch the delicate procedure and learn from the mistakes of others. It may not be as detailed a simulation environment as some, but “blade time” is really what counts here.

3D Printed Artificial Nose Is Totally Vegan

April 14, 2023 by Lewin Day 13 Comments

Prosthetics are complicated, highly personal things. They must often be crafted and customized precisely to suit the individual. Additive manufacturing is proving a useful tool in this arena, as demonstrated by a new 3D printed nose design developed at Swansea University. And a bonus? It’s vegan, too!

Often, cartilage from the ribcage is used when reconstructing a patient’s nose. However, this procedure is invasive and can lead to health complications. Instead, a nanocellulose hydrogel made from pulped softwood, combined with hyaluronic acid, may be a viable printable material for creating a scaffold for cartilage cells. The patients own cartilage cells can be used to populate the scaffold, essentially growing a new nose structure from scratch. The technique won’t just be limited to nose reconstructions, either. It could also help to recreate other cartilage-based structures, such as the ear.

As with all new medical technologies, the road ahead is long. Prime concerns involve whether the material is properly bio-compatible, particularly where the immune system is concerned. However, the basic idea is one that’s being pursued in earnest by researchers around the world, whether for cosmetic purposes or to grow entire organs. As always, if you’re secretly 3D printing functional gallbladders in your basement, don’t hesitate to drop us a line.

App Detects Parkinsons Disease And COVID-19 Via Audio

November 28, 2022 by Lewin Day 20 Comments

One of the challenges of diagnosing diseases is identifying them early. At this stage, signs may be vague or confusing, or difficult to identify. Early diagnosis is often tied to the best possible treatment outcomes, so there’s plenty of incentives to improve methods in this way.

A new voice-based method of diagnosing disease could prove fruitful in this regard. It relies on machine learning techniques to detect when patients may be suffering from certain conditions.

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