Antiviral PPE For The Next Pandemic

In what sounds like the plot from a sci-fi movie, scientists have isolated an incredibly rare immune mutation to create a universal antiviral treatment.

Only present in a few dozen people worldwide, ISG15 immunodeficiency causes people to be more susceptible to certain bacterial illnesses, but it also grants the people with this condition immunity to known viruses. Researchers think that the constant, mild inflammation these individuals experience is at the root of the immunoresponse.

Where things get really interesting is how the researchers have found a way to stimulate protein production of the most beneficial 10 proteins of the 60 created by the natural mutation using 10 mRNA sequences inside a lipid nanoparticle. Lead researcher [Dusan Bogunovic] says “we have yet to find a virus that can break through the therapy’s defenses.” Researchers hope the treatment can be administered to first responders as a sort of biological Personal protective equipment (PPE) against the next pandemic since it would likely work against unknown viruses before new targeted vaccines could be developed.

Hamsters and mice were given this treatment via nasal drip, but how about intranasal vaccines when it comes time for human trials? If you want a short history of viruses or to learn how smartwatches could help flatten the curve for the next pandemic, we’ve got you covered.

A fisheye lens picture over the Junma Solar Power station in the Mongolian desert. There is a large image of a horse made out of solar panels in the image. A sunset is visible in the upper right of the image, but most the picture is brown sand where there aren't dark blue solar panels.

China’s Great Solar Wall Is A Big Deal

Data centers and the electrification of devices that previously ran on fossil fuels is driving increased demand for electricity around the world. China is addressing this with a megaproject that is a new spin on their most famous piece of infrastructure.

At 250 miles long and 3 miles wide with a generating capacity of 100 GW, the Great Solar Wall will be able to provide enough energy to power Beijing, although the energy will more likely be used to power industrial operations also present in the Kubuqi Desert. NASA states, “The Kubuqi’s sunny weather, flat terrain, and proximity to industrial centers make it a desirable location for solar power generation.” As an added bonus, previous solar installations in China have shown that they can help combat further desertification by locking dunes in place and providing shade for plants to grow.

Engineers must be having fun with the project as they also designed the Guinness World Record holder for the largest image made of solar panels with the Junma Solar Power Station (it’s the horse in the image above). The Great Solar Wall is expected to be completed by 2030 with 5.4 GW already installed in 2024.

Want to try solar yourself on a slightly smaller scale? How about this solar thermal array inspired by the James Webb Telescope or building a solar-powered plane?

A black and white device sits on a beige table. A white rotary knob projects out near the base of it's rectangular shape nearest the camera. Near it is a black rectangular section of the enclosure with six white dots protruding through holes to form a braille display. A ribbon cable snakes out of the top of the enclosure and over the furthest edge of the device, presumably connecting to a camera on the other side of the device.

This Polaroid-esque OCR Machine Turns Text To Braille In The Wild

One of the practical upsides of improved computer vision systems and machine learning has been the ability of computers to translate text from one language or format to another. [Jchen] used this to develop Braille Vision which can turn inaccessible text into braille on the go.

Using a headless Raspberry Pi 4 or 5 running Tesseract OCR, the device has a microswitch shutter to take a picture of a poster or other object. The device processes any text it finds and gives the user an audible cue when it is finished. A rotary knob on the back of the device then moves the braille display pad through each character. When the end of the message is reached, it then cycles back to the beginning.

Development involved breadboarding an Arduino hooked up to some MOSFETs to drive the solenoids for the braille display until the system worked well enough to solder together with wires and perfboard. Everything is housed in a 3D printed shell that appears similar in size to an old Polaroid instant camera.

We’ve seen a vibrating braille output prototype for smartphones, how blind makers are using 3D printing, and are wondering what ever happened with “tixel” displays? If you’re new to braille, try 3D printing your own trainer out of TPU.

Continue reading “This Polaroid-esque OCR Machine Turns Text To Braille In The Wild”

A hand with dark skin holds a black device. The bottom is a small keyboard and touchpad. The upper half is split with a square LCD on the left and a square, pink notepad on the right. A sketch of a woman wearing a puffy jacket is on the notepad and an illustration of a woman looking through an old timey film video camera is on the screen on the left.

KeyMo Brings A Pencil To The Cyberdeck Fight

Computers and cellphones can do so many things, but sometimes if you want to doodle or take a note, pencil and paper is the superior technology. You could carry a device and a pocket notebook, or you could combine the best of analog and digital with the KeyMo.

[NuMellow] wanted a touchpad in addition to a keyboard for his portable terminal since he felt Raspbian wouldn’t be so awesome on a tiny touchscreen. With a wider device than something like Beepy, and a small 4″ LCD already on hand, he realized he had some space to put something else up top. Et voila, a cyberdeck with a small notebook for handwritten/hand drawn information.

The device lives in a 3D printed case, which made some iterations on the keyboard placement simpler, and [NuMellow] even provided us with actual run time estimates in the write-up, which is something we often are left wondering about in cyberdeck builds. If you’re curious, he got up to 7.5 hours on YouTube videos with the brightness down or 3.5 hours with it at maximum. The exposed screen and top-heaviness of the device are areas he’s pinpointed as the primary cons of the system currently. We hope to see an updated version in the future that addresses these.

If you’d like to check out some other rad cyberdecks, how about a schmancy handheld, one driven by punch cards in a child’s toy, or this one with a handle and a giant scroll wheel?

An image of a light grey graphing calculator with a dark grey screen and key surround. The text on the monochrome LCD screen shows "Input: ENEB Result 1: BEEN Confidence 1: 14% [##] Result 2: Good Confidence 2: 12% [#] Press ENTER key..."

A Neural Net For A Graphing Calculator?

Machine learning and neural nets can be pretty handy, and people continue to push the envelope of what they can do both in high end server farms as well as slower systems. At the extreme end of the spectrum is [ExploratoryStudios]’s Hermes Optimus Neural Net for a TI-84 Plus Silver Edition.

This neural net is setup as an autocorrect system that can take four character inputs and match them to a library of twelve words. That’s not a lot, but we’re talking about a device with 24 kB of RAM, so the little machine is doing its best. Perhaps more interesting than any practical output is the puzzle solving involved in getting this to work within the memory constraints.

The neural net “employs a feedforward neural network with a precisely calibrated 4-60-12 architecture and sigmoid activation functions.” This leads to an approximate 85% accuracy being able to identify and correct the given target words. We appreciate the readout of the net’s confidence as well which is something that seems to have gone out the window with many newer “AI” systems.

We’ve seen another TI-84 neural net for handwriting recognition, but is the current crop of AI still headed in the wrong direction?

Continue reading “A Neural Net For A Graphing Calculator?”

A black and white illustration of people with headphones or microphones and floating empty speech bubbles. They appear happy and engaged with each other in a pleasant, park-like environment. In the foreground, on top of a wall, various anthropomorphized big tech logos like Apple, Amazon, and Google spy down on the people with binoculars like hunters assessing their prey. The text reads, "But like any good thing on the internet, there's a big tech monopoly trying to ruin it."

Long Live RSS!

While we know that many of you are reading Hackaday via our Really Simple Syndication (RSS) feed, we suspect that most people on the street wouldn’t know that it underlies a lot of the modern internet. [A. McNamee] and [A. Service] have created an illustrated history of RSS that proudly proclaims RSS is (not) dead (yet)!

While tens of millions of users used Google Reader before it was shut down, social media and search companies have tried to squeeze independent blogs and websites for an increasingly large part of their revenue, making it more and more difficult to exist outside the walled gardens of Facebook, Apple, Google, etc. Despite those of you that remember, RSS has been mostly forgotten.

RSS has been the backbone of the podcast industry, however, quietly serving feeds to millions of users everywhere with few of them aware that an open protocol from the 90s was serving up their content. As with every other corner of the internet where money could be made, corporate raiders have come to scoop up creators and skim the profits for themselves. Spotify has been the most egregious actor here, but the usual suspects of Apple, Google, and Amazon are also making plays to enclose the podcast commons.

If you’d like to learn more about how big tech is sucking the life out of the internet (and possibly how to reverse the enshittification) check out Cory Doctorow’s keynote from our very own Supercon.

Generatively-Designed Aerospike Test Fired

The aerospike engine holds great promise for spaceflight, but for various reasons, has remained slightly out of reach for decades. But thanks to Leap 71, the technology has moved one step closer to a spacecraft near you with the test fire of their generatively-designed, 3D printed aerospike.

We reported on the original design process of the engine, but at the time it hadn’t been given a chance to burn its liquid oxygen and kerosene fuel. The special sauce was the application of a computational physics model to tackle the complex issue of keeping the engine components cool enough to function while directing 3,500˚C exhaust around the eponymous spike.

Printed via a powder bed process out of CuCrZr, cleaned, heat treated, and then prepped by the University of Sheffield’s Race 2 Space Team, the rocket produced 5,000 Newtons (1,100 lbf) of thrust during its test fire. For comparison, VentureStar, the ill-fated aerospike single stage to orbit project from the 1990s, was projected to produce more than 1,917 kilonewtons (431,000 lbf) from each of its seven RS-2200 engines. Leap 71 obviously has some scaling up to do before this can propel any crewed spacecraft.

If you want to build your own aerospike or 3D printed rocket nozzles we encourage you to read, understand, and follow all relevant safety guidelines when handling your rockets. It is rocket science, after all!