Angry antibodies

Monoclonal Antibodies: The Guided Missiles Of Medicine

September 15, 2021 by 11 Comments

Whenever anyone mentions the word “antibodies” these days, it’s sure to grab your attention. Thoughts generally flow to the human immune system and the role it plays in the ongoing COVID-19 pandemic, and to how our bodies fight off disease in general. The immune system is complex in the extreme, but pretty much everyone knows that antibodies are part of it and that they’re vital to the ability of the body to recognize and neutralize invaders like bacteria and viruses.

But as important as antibodies are to long-term immunity and the avoidance of disease, that’s far from all they’re good for. The incredible specificity of antibodies to their target antigens makes them powerful tools for biological research and clinical diagnostics, like rapid COVID-19 testing. The specificity of antibodies has also opened up therapeutic modalities that were once the stuff of science-fiction, where custom-built antibodies act like a guided missile to directly attack not only a specific protein in the body, but sometimes even a specific part of a protein.

Making these therapies work, though, requires special antibodies: monoclonal antibodies. These are very much in the news recently, not only as a possible treatment for COVID-19 but also to treat everything from rheumatoid arthritis to the very worst forms of cancer. But what exactly are monoclonal antibodies, how are they made, and how do they work?

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Bringing A Ruined Game Boy Cart Back To Life With Tons Of Soldering

September 15, 2021 by 17 Comments

Retro consoles and handhelds are full of nostalgia and happy memories for many. However, keeping these machines and their media going can be a difficult job at times. [Taylor] was challenged to rescue a copy of Kirby’s Dream Land for the original Game Boy, and set about the task.

The cartridge was badly corroded, with many of the traces eaten through, rendering the game inoperable. First, all the components were removed, and the board was cleaned. This allowed easy access to the traces across the whole board. Then, the job was to delicately remove some solder mask from the parts of the traces still remaining, and bridge the gaps with fine copper wire. Even worse, several vias were damaged, which [Taylor] tackled by feeding jumper wires through the board and executing a repair on each side.

It’s a simple enough repair for the experienced hand, but virtually magic to a retro gaming fan that doesn’t know how to solder. [Taylor] has given us a great example of how to deal with corroded carts properly, with enough detail to be quite educational to the beginner.

We’ve seen other great work in this vein too, like an Amiga 2000 brought back from a horrible creeping green death. If you’ve done your own retro rescue, be sure to drop us a line!

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German Experiment Shows Horses Beating Local Internet Connections

September 15, 2021 by 61 Comments

These days, we’re blessed with wired and wireless networks that can carry huge amounts of data in the blink of an eye. However, some areas are underprovisioned with bandwidth, such as Schmallenberg-Oberkirchen in Germany. There, reporters ran a test last December to see which would be faster: the Internet, or a horse?

The long and the short of it is that Germany faces issues with disparate Internet speeds across the country. Some areas are well-served by high-speed fiber services. However, others deemed less important by the free market struggle on with ancient copper phone lines and subsequently, experience lower speeds.

Thus, the experiment kicked off from the house of photographer [Klaus-Peter Kappest], who started an Internet transfer of 4.5GB of photos over the Internet. At the same time, a DVD was handed to messengers riding on horseback to the destination 10 kilometers away. The horses won the day, making the journey in about an hour, while the transfer over [Kappest’s] copper connection was still crawling along, only 61% complete.

Obviously, it’s a test that can be gamed quite easily. The Internet connection would have easily won over a greater distance, of course. Similarly, we’ve all heard the quote from [Andrew Tanenbaum]: “Never underestimate the bandwidth of a station wagon full of tapes hurtling down the highway.”

Notably, [Kappest’s] home actually had a fiber line sitting in the basement, but bureaucracy had stymied any attempts of his to get it connected. The stunt thus also served as a great way to draw attention to his plight, and that of others in Germany suffering with similar issues in this digital age.

Top speeds for data transfer continue to rise; an Australian research team set a record last year of 44.2 terabits per second. Naturally, the hard part is getting that technology rolled out across a country. Sound off below with the problems you’ve faced getting a solid connection to your home or office.

Useless Machine Is A Clock

September 14, 2021 by 15 Comments

Useless machines are a fun class of devices which typically turn themselves off once they are switched on, hence their name. Even though there’s no real point, they’re fun to build and to operate nonetheless. [Burke] has followed this idea in spirit by putting an old clock he had to use with his take on a useless machine of sorts. But instead of simply powering itself off when turned on, this useless machine dislodges itself from its wall mount and falls to the ground anytime anyone looks at it.

It’s difficult to tell if this clock was originally broken when he started this project, or if many rounds of checking the time have caused the clock to damage itself, but either way this project is an instant classic. Powered by a small battery driving a Raspberry Pi, the single-board computer runs OpenCV and is programmed to recognize any face pointed in its general direction. When it does, it activates a small servo which knocks it off of its wall, rendering it unarguably useless.

[Burke] doesn’t really know why he had this idea, but it’s goofy and fun. The duct tape that holds everything together is the ultimate finishing touch as well, and we can’t really justify spending too much on fit and finish for a project that tosses itself around one’s room. On the other hand, if you’re looking for a more refined useless machine, we have seen some that have an impressive level of intricacy.

Thanks to [alchemyx] for the tip!

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Hacking The Wooly Mammoth

September 14, 2021 by 19 Comments

In case you can’t get enough Jurassic Park movies, you can look forward to plans a biotech company has to hybridize endangered Asian elephants with long-extinct wooly mammoths using gene splicing and other exotic techniques.

Expect a long movie, the team hopes to have calves after six years and we don’t think a theme park is in the making. The claim is that mammoth traits will help the elephants reclaim the tundra, but we can’t help but think it is just an excuse to reanimate an extinct animal. If you read popular press reports, there is some question if the ecological mission claimed by the company is realistic. However, we can’t deny it would be cool to bring an animal back from extinction — sort of.

We aren’t DNA wizards, so we only partially understand what’s being proposed. Apparently, skin cells from a modern elephant will serve as a base to accept extracted mammoth DNA. This might seem far-fetched but turns out the mammoth lived much more recently than we usually think. When they die in their natural deep-freeze environment, they are often well preserved.

Once the gene splicing is set up, a surrogate elephant will carry the embryo to term. The hope is that the improved breed would be able to further interbreed with natural species, although with the gestation and maturity times of elephants, this will be a very long time to bear fruit.

So how do you feel about it? Will we face a movie-level disaster? Will we get some lab curiosity creatures? Will it save the tundra? Let us know what you think in the comments.

DNA manipulation has gone from moon-shot-level tech to readily accessible in a very short amount of time. In particular, CRISPR, changes everything and is both exciting and scary on what it puts in the hands of nearly anyone.

Harp Uses Frikin’ Lasers

September 14, 2021 by 12 Comments

We aren’t sure if you really need lasers to build [HoPE’s] laser harp. It is little more than some photocells and has an Arduino generate tones based on the signals. Still, you need to excite the photocells somehow, and lasers are cheap enough these days.

Mechanically, the device is a pretty large wooden structure. There are six lasers aligned to six light sensors. Each sensor is read by an analog input pin on an Arduino armed with a music-generation shield. We’ve seen plenty of these in the past, but the simplicity of this one is engaging.

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Robert Dunn holds a button in his hand for controlling a spot welder

Gorgeous Battery Welder Hits The Spot

September 14, 2021 by 32 Comments

Raise you’re hand if you’ve ever soldered directly to a battery even though you know better. We’ve all been there. Sometimes we get away with it when we have a small pack and don’t care about longevity. But when [Robert Dunn] needed to build a battery pack out of about 120 Lithium Ion cells, he knew that he had to do it The Right Way and use a battery spot welder. Of course, buying one is too simple for a hacker like [Robert]. And so it was that he decided to Build a Spot Welder from an old Microwave Oven and way too much mahogany, which you can view below the break.

A Battery Cell with a spot welding tab attached
Spot Welding leaves two familiar divots in the attached tab, which can be soldered or welded as need.

For the unfamiliar, a battery spot welder is the magical device that attaches tabs to rechargeable batteries. You’ll notice that all battery packs with cylindrical cells have a tab with two small dimples. These dimples are where high amperage electricity quickly heats the battery terminal and the tab until they’re red hot, welding them together. The operation is done and over in less than a second, well before any heat damage can be done. The tab can then be soldered to or spot welded to another cell.

One of the most critical parts of spot welding batteries is timing. While [Robert Dunn] admits that a 555 timer or even just a manual switch and relay could have done the job, he opted for an Arduino Uno with a 4 character 7 segment LED display that shows the welding time in milliseconds. A 3d printed trigger and welder handle wrap up the hardware nicely.

The build is topped off by a custom mahogany enclosure that is quite a bit overdone. But if one has the wood, the time, the tools and skills (and a YouTube channel perhaps?) there’s no reason not to put in the extra effort! [Robert]’s resulting build is almost too nice, but it’ll certainly get the job done.

Of course, spot welders are almost standard fare here at Hackaday, and we’ve covered The Good, The Bad, and The Solar. Do you have a battery welder project that deserves a spot in Hackaday’s rotation? By all means, send it over to the Tip Line!

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