New Drug Has Potential As Dirty Bomb Antidote

May 25, 2023 by 39 Comments

It perhaps goes without saying that one nuclear bomb can really ruin your day. The same is true for non-nuclear dirty bombs, which just use conventional explosives to disperse radioactive material over a wide area. Either way, the debris scattered by any type of radiation weapon has the potential to result in thousands or perhaps millions of injuries, for which modern medicine offers little in the way of relief.

HOPO 14-1, aka 3,4,3-Li(1,2-HOPO). The four hydroxypyridinone groups do the work of coordinating radioactive ions and making them soluble so they can be eliminated in urine.

But maybe not for long. A Phase 1 clinical trial is currently underway to see if an oral drug is able to scour radioactive elements from the human body. The investigational compound is called HOPO 14-1, a chelating agent that has a high affinity for metals in the actinide series, which includes plutonium, uranium, thorium, and cerium curium. Chelating agents, which are molecules that contain a multitude of electron donor sites, are able to bind to positively charged metal ions and make the soluble in aqueous solutions. Chelators are important in food and pharmaceutical processing — read the ingredients list on just about anything from a can of soda to a bottle of shampoo and you’re likely to see EDTA, or ethylenediaminetetraacetic acid, which binds to any metal ions that make it into the product, particularly iron ions that come from the stainless steel plumbing used in processing equipment.

The compound under evaluation, HOPO 14-1, is a powerful chelator of metal ions. Its structure is inspired by natural chelators produced by bacteria and fungi, called siderophores, which help the microorganisms accumulate iron. Its mechanism of action is to sequester the radioactive ions and make them soluble enough to be passed out of the body in the urine, rather than to have the radioactive elements carried around the body and incorporated into the bones and other tissues where they can cause radiation damage for years.

HOPO 14-1 has a number of potential benefits over the current frontline chelator for plutonium and uranium toxicity, DTPA or diethylenetriaminepentaacetic acid. Where DTPA needs to be injected intravenously to be effective, HOPO 14-1 can be made into a pill, making stockpiling and administering the drug easier. If, of course, it passes Phase 1 safety trials and survives later trials to determine efficacy.

3D Model Subscriptions Are Coming, But Who’s Buying?

May 25, 2023 by 51 Comments

We’ve all been there before — you need some 3D printable design that you figure must be common enough that somebody has already designed it, so you point your browser to Thingiverse or Printables, and in a few minutes you’ve got STL in hand and are ready to slice and print. If the design worked for you, perhaps you’ll go back and post an image of your print and leave a word of thanks to the designer.

Afterwards, you’ll probably never give that person a second thought for the rest of your life. Within a day or two, there’s a good chance you won’t even remember their username. It’s why most of the model sharing sites will present you with a list of your recently downloaded models when you want to upload a picture of your print, otherwise there’s a good chance you wouldn’t be able to find the thing.

Now if you really liked the model, you might go as far as following the designer. But even then, there would likely be some extenuating circumstances. After all, even the most expertly designed widget is still just a widget, and the chances of that person creating another one that you’d also happen to need seems exceedingly slim. Most of the interactions on these model sharing sites are like two ships passing in the night; it so happened that you and the creator had similar enough needs that you could both use the same printable object, but there’s no telling if you’ll ever cross paths with them again.

Which is why the recent announcements, dropped just hours from each other, that both Thangs and Printables would be rolling out paid subscription services seems so odd. Both sites claim that not only is there a demand for a service that would allow users to pay designers monthly for their designs, but that existing services such as Patreon are unable to meet the unique challenges involved.

Both sites say they have the solution, and can help creators turn their passion for 3D design into a regular revenue stream — as long as they get their piece of the action, that is.

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Bankruptcy Sale Scatters Virgin Orbit To The Winds

May 25, 2023 by 19 Comments

When Virgin Orbit filed for bankruptcy in April, it was clear the commercial launch provider was in serious trouble. Despite successfully putting four payloads into low Earth orbit, the spin-off of Richard Branson’s Virgin Galactic space tourism company had struggled to achieve a high enough launch cadence to become profitable, and had recently suffered a highly-publicized failure when their first launch from the UK from the newly-completed Spaceport Cornwall ended in a complete loss of the vehicle.

There was some hope that a buyer would swoop in and save them at the last minute, but now that the bankruptcy auction has spread out the company’s assets among several other players in the commercial launch industry, Virgin Orbital is officially no more. With future launches now off the table, the company’s remaining employees are set to be let go as operations wind down over the coming weeks.

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Adding Variometer Functionality To A GPS

May 25, 2023 by 10 Comments

Flying a glider, or similarly piloting a paraglider or hang glider, can all be pathways into aviation with a lower barrier of entry than powered flight. Sacrificing one’s engine does generate a few complexities, but can be rewarding as the pilot searches for various means of increasing altitude like ridge soaring or thermaling. You’ll need a special instrument called a variometer to know just how much altitude you’re gaining though, like this one which is built into commercially-available handheld GPS units.

These GPS units are normally intended for use on terra firma only, but [Oganisyan] has figured out a clever way to add this flight instrumentation to these units to help when operating a paraglider. An ATmega328 paired with a pressure sensor is added to the inside of the GPS units and communicates with an available serial interface within the units. To complete the modification, a patched firmware must be installed which adds the variometer function to the display. This upgrade is compatible with a handful of GPS units as well such as the BikePilot2+ or Falk Tiger.

For those who already own one of these GPS units, this could be a cost-effective way of obtaining a variometer, especially since commercially-available variometers tailored for this sort of application can cost around $200 to $500. It is an activity sensitive to cost, though, as it offers a much more affordable option for taking to the skies than any powered craft could, with an exception made for this powered paraglider which offers the ability for powered take off and flight extension using electric-powered props.

Thanks to [MartinO] for the tip!

An orange and green stained glass robot arm sits on a table with a yellow lace tablecloth. It suspends a teabag over a brown teacup. You can see green leaves outside the window behind the bot.

Glass Robot From A Solarpunk Future

May 24, 2023 by 5 Comments

You may have heard of a heart of glass or have a glass jaw, but have you ever seen a glass robot?

[Simone Giertz], has taken two of her favorite things, stained glass and robotics, and fused them into a single project. Using an existing metal robot arm as a template, she cut and soldered her stained glass panels before reassembling the robot with its new solarpunk limbs. During testing though, one of the glass panels repeatedly failed at a solder joint.

Undaunted, [Giertz] replaced the faulty piece with an original metal component allowing this “grandma cyberpunk-core” bot to prepare tea as intended. We really love when makers bring us through the whole process, mishaps and all, and [Giertz] never disappoints in this respect. We do wonder a bit about the long-term health impacts of making tea with a robot containing leaded solder though.

If you’re interested in more robots made from unusual materials, checkout this gripper made from a dead spider or this work on phase changing robots.

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Mapping of the displacement of a tympanum of the lesser wax moth (Achroia grisella). (Credit: Andrew Reid)

3D Printing Bio-Inspired Microphone Designs Based On Moth Ears

May 24, 2023 by 5 Comments

If many millions of years of evolution is good for anything, it is to develop microscopic structures that perform astounding tasks, such as the marvelous biology of insects. One of these structures are the ears of the lesser wax moth (Achroia grisella), whose mating behavior involves ultrasonic mating calls. These can attract the bats which hunt them, leading to these moths having evolved directional hearing that can pinpoint not only a potential mate, but also bat calling sound.

What’s most astounding about this is that these moths that only live about a week as an adult can perform auditory feats that we generally require an entire microphone array for, along with a lot of audio processing. The key that enables these moths to perform these feats lies in their eardrum, or tympanum. Rather than the taut, flat surface as with mammals, these feature intricate 3D structures along with pores that seem to perform much of the directional processing, and this is what researchers have been trying to replicate for a while, including a team of researchers at the University of Strathclyde.

To create these artificial tympanums, the researchers used a flexible hydrogel, with a piezoelectric material that converts the acoustic energy into electric signals, connected to electrical traces. The 3D features are printed on this, mixed with methanol that forms droplets inside the curing resin, before being expelled and leaving the desired pores. One limitation is that currently used printers have a limited resolution of about 200 micrometers, which doesn’t cover the full features of the insect’s tympanum.

Assuming this can be made to work, it could be used for everything from cochlear implants to anywhere else that has a great deal of audio processing that needs downsizing.

(Heading image: Mapping of the displacement of a tympanum of the lesser wax moth (Achroia grisella). (Credit: Andrew Reid) )

Automatic Coin Sorter Brings Order To Your Coin Jar

May 24, 2023 by 20 Comments

Few things hold as much promise as the old coin jar. Unfortunately, what’s generally promised is tedium, as one faces the prospect of manually sorting, counting, and rolling the accumulated change of cash transactions past. Unless, of course, you’ve got a fancy automatic coin sorter like this one.

True, many banks have automatic coin sorters, but you generally have to be a paying customer to use one. And there’s always Coinstar and similar kiosks, but they always find a way to extract a fee, one way or another. [Fraens] decided not to fall for either of those traps and roll his own machine, largely from 3D-printed parts. The basic mechanism is similar to that used in commercial coin counters, with an angled bowl rotating over an array of holes sized to fit various coins. Holes in the bottom of the feed bowl accept coins fed from a hopper and transport them up to the coin holes. The smallest coins fall out of the bowl first, followed by the bigger coins; each coin drops into a separate bin after passing through an optical sensor to count the number of each on an Arduino. Subtotals and a grand total of the haul are displayed on a small LCD screen. The video below shows the build and the sorter in operation.

[Fraens] built this sorter specifically for Euro coins, but it should be easy enough to modify the sorting slots for different currencies. It’s not the first coin sorter we’ve seen, of course, and while we applaud its design simplicity and efficient operation, it can’t hold a candle to the style of this decidedly less practical approach.

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