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Ask Hackaday: What Can Only A Computer Do?

September 22, 2021 by 128 Comments

It is easy to apply computers to improve things we already understand. For example, instead of a piano today, you might buy a synthesizer. It looks and works — sometimes — as a piano. But it can also do lots of other things like play horns, or accompany you with a rhythm track or record and playback your music. There’s plenty of examples of this: word processors instead of typewriters, MP3 players instead of tape decks, and PDF files instead of printed material. But what about something totally new? I was thinking of this while looking at Sonic Pi, a musical instrument you play by coding.

But back to the keyboard, the word processor, and the MP3 player. Those things aren’t so much revolutionary as they are evolutionary. Even something like digital photography isn’t all that revolutionary. Sure, most of us couldn’t do all the magic you can do in PhotoShop in a dark room, but some wizards could. Most of us couldn’t lay out a camera-ready brochure either, but people did it every day without the benefit of computers. So what are the things that we are using computers for that are totally new? What can you do with the help of a computer that you absolutely couldn’t without?

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Mechanisms Behind Vaccine Side-Effects: The Science That Causes That Sore Arm

September 21, 2021 by 85 Comments

After receiving a vaccination shot, it’s likely that we’ll feel some side-effects. These can range from merely a sore arm to swollen lymph nodes and even a fever. Which side-effects to expect depend on the exact vaccine, with each type and variant coming with its own list of common side-effects. Each person’s immune system will also react differently, which makes it hard to say exactly what one can expect after receiving the vaccination.

What we can do is look closer at the underlying mechanisms that cause these side-effects, to try and understand why they occur and how to best deal with them. Most relevant here for the initial response is the body’s innate immune system, with dendritic cells generally being among the first to come into contact with the vaccine and to present the antigen to the body’s adaptive immune system.

Key to the redness, swelling, and fever are substances produced by the body which include various cytokines as well as prostaglandin, producing the symptoms seen with inflammation and injury.

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Hacking When It Counts: Surgery Fit To Save A Future King

September 20, 2021 by 41 Comments

When we picture the Medieval world, it conjures up images of darkness, privations, and sickness the likes of which are hard to imagine from our sanitized point of view. The 1400s, and indeed the entirety of history prior to the introduction of antibiotics in the 1940s, was a time when the merest scratch acquired in the business of everyday life could lead to an infection ending in a slow, painful death. Add in the challenges of war, where violent men wielding sharp things on a filthy field of combat, and it’s a wonder people survived at all.

But then as now, some people are luckier than others, and surviving what even today would likely be a fatal injury was not unknown, as one sixteen-year-old boy in 1403 would discover. It didn’t hurt that he was the son of the king of England, and when he earned an arrow in his face in combat, every effort would be made to save the prince and heir to the throne. It also helped that he had the good fortune to have a surgeon with the imagination to solve the problem, and the skill to build a tool to help.

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Powering Up With USB: Untangling The USB Power Delivery Standards

September 16, 2021 by 37 Comments

Powering external devices directly from a PC’s I/O ports has been a thing long before USB was even a twinkle in an engineer’s eye. Some of us may remember the all too common PS/2 pass-through leads that’d tap into the 275 mA that is available via these ports. When USB was first released, it initially provided a maximum of 500 mA which USB 3.0 increased to 900 mA.

For the longest time, this provided power was meant only to provide a way for peripherals like keyboards, mice and similar trivial devices to be powered rather than require each of these to come with its own power adapter. As the number of  computer-connected gadgets increased USB would become the primary way to not only power small devices directly, but to also charge battery-powered devices and ultimately deliver power more generally.

Which brings us to the USB Power Delivery (USB-PD) protocol. Confusingly, USB-PD encompasses a number of different standards, ranging from fixed voltage charging to Programmable Power Supply and Adjustable Voltage Supply. What are the exact differences between these modes, and how does one go about using them? Continue reading “Powering Up With USB: Untangling The USB Power Delivery Standards” →

Angry antibodies

Monoclonal Antibodies: The Guided Missiles Of Medicine

September 15, 2021 by 11 Comments

Whenever anyone mentions the word “antibodies” these days, it’s sure to grab your attention. Thoughts generally flow to the human immune system and the role it plays in the ongoing COVID-19 pandemic, and to how our bodies fight off disease in general. The immune system is complex in the extreme, but pretty much everyone knows that antibodies are part of it and that they’re vital to the ability of the body to recognize and neutralize invaders like bacteria and viruses.

But as important as antibodies are to long-term immunity and the avoidance of disease, that’s far from all they’re good for. The incredible specificity of antibodies to their target antigens makes them powerful tools for biological research and clinical diagnostics, like rapid COVID-19 testing. The specificity of antibodies has also opened up therapeutic modalities that were once the stuff of science-fiction, where custom-built antibodies act like a guided missile to directly attack not only a specific protein in the body, but sometimes even a specific part of a protein.

Making these therapies work, though, requires special antibodies: monoclonal antibodies. These are very much in the news recently, not only as a possible treatment for COVID-19 but also to treat everything from rheumatoid arthritis to the very worst forms of cancer. But what exactly are monoclonal antibodies, how are they made, and how do they work?

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The World’s First Autonomous Electric Cargo Ship Is Due To Set Sail

September 14, 2021 by 55 Comments

Maritime shipping is big business, with gigantic container ships responsible for moving the vast majority of the world’s goods from point A to points B, C and D. Of course, there’s a significant environmental impact from all this activity, something ill befitting the cleaner, cooler world we hope the future will be. Thus, alternatives to the fossil fuel burning ships of old must be found. To that end, Norwegian company Yara International has developed a zero-emission ship by the name of Yara Birkeland, which aims to show the way forward into a world of electric, autonomous sea transport. 

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NASA Are Squaring Up Against The Asteroid Threat

September 10, 2021 by 43 Comments

The world faces many terrestrial crises right now, so it’s easy to forget that giant space rocks may one day threaten the very existence of entire civilizations. Yes, the threat of asteroid strikes is a remote one, but nevertheless something humanity may have to face one day, and one day soon.

NASA takes the issue seriously, and has staffed its Planetary Defence Coordination Office since 2016. In service to these efforts, it’s also developing a mission to research how dangerous androids may be deflected. The Double Asteroid Redirection Test, or DART, is set to launch within the next year. Continue reading “NASA Are Squaring Up Against The Asteroid Threat” →