Swine Of The Times: Pig-to-Human Organ Transplants On Track For 2021

January 28, 2021 by Kristina Panos 73 Comments

Every day in the US, seventeen people die because they couldn’t get a organ transplant in time. An American biotech company called United Therapeutics is looking to pick up the lifesaving slack by producing a line of genetically-modified pigs for the purpose of harvesting their organs, among other therapeutic uses. United Therapeutics’ pig-farming subsidiary Revivicor is a spin-off of PPL Therapeutics, the company that gave us Dolly the cloned sheep back in 1996. They intend to start transplanting pig organs into humans as early as this year.

Baby Fae after transplant surgery. Image by Duane Miller-AP via Time Magazine

Although it sounds like science fiction, the idea of transplanting animal cells, organs, and tissue into humans has been around for over a hundred years. The main problem with xenotransplantation is that it usually triggers severe immune system reactions in the recipient’s body. In one of the more noteworthy cases, a baby girl received a baboon heart in 1984, but died a few weeks later because her body rejected the organ.

The leading cause of xenotransplant rejection is a sugar called alpha-gal. This sugar appears on the cell surfaces of all non-primate mammals. Alpha-gal is problematic for other reasons, too: a condition called alpha-gal syndrome usually begins when a Lone Star tick bites a person and transmits alpha-gal cells from the blood of animals they have bitten. From that point on, the person will experience an allergic reaction when eating red meat such as beef, pork, and lamb.

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Sony’s Electric Car Now Road Testing In Austria

January 27, 2021 by Lewin Day 73 Comments

The Consumer Electronics Show was not typically a place for concept cars, and Sony aren’t known as a major automaker. However, times change, and the electric transport revolution has changed much. At the famous trade show, Sony shocked many by revealing its Vision-S concept — a running, driving, prototype electric car.

Far from a simple mockup to show off in-car entertainment or new fancy cameras, Sony’s entry into the automotive world is surprisingly complete. Recently, the Japanese tech giant has been spotted testing the vehicle on the road in Austria, raising questions about the future of the project. Let’s dive in to what Sony has shown off, and what it means for the potential of the Vision-S.

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The Origin Of Cut, Copy, And Paste

January 20, 2021 by Al Williams 90 Comments

I’m always fascinated that someone designed just about everything you use, no matter how trivial it is. The keyboard you type on, the light switch you turn on, even the faucet handle. They don’t just spontaneously grow on trees, so some human being had to build it and probably had at least a hazy design in mind when they started it.

Some things are so ubiquitous that it is hard to remember that someone had to dream them up to begin with. A friend of mine asked me the other day why we use Control+X and Control+V to manipulate the clipboard almost universally. Control+C for copy makes sense, of course, but it is still odd that it is virtually universal in an industry where everyone likes to reinvent the wheel. I wasn’t sure of the answer but figured it had to do with some of the user interface standards from IBM or Sun. Turns out, it is much older than that.

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A New Era Of Spacecraft Delivers Science On Time

January 19, 2021 by Tom Nardi 17 Comments

When the Space Shuttle Atlantis rolled to a stop on its final mission in 2011, it was truly the end of an era. Few could deny that the program had become too complex and expensive to keep running, but even still, humanity’s ability to do useful work in low Earth orbit took a serious hit with the retirement of the Shuttle fleet. Worse, there was no indication of when or if another spacecraft would be developed that could truly rival the capabilities of the winged orbiters first conceived in the late 1960s.

While its primary function was to carry large payloads such as satellites into orbit, the Shuttle’s ability to retrieve objects from space and bring them back was arguably just as important. Throughout its storied career, sensitive experiments conducted at the International Space Station or aboard the Orbiter itself were returned gently to Earth thanks to the craft’s unique design. Unlike traditional spacecraft that ended their flight with a rough splashdown in the open ocean, the Shuttle eased itself down to the tarmac like an airplane. Once landed, experiments could be quickly unloaded and transferred to the nearby Space Station Processing Facility where science teams would be waiting to perform further processing or analysis.

*Atlantis* is towed from the runway for payload processing.

For 30 years, the Space Shuttle and its assorted facilities at Kennedy Space Center provided a reliable way to deliver fragile or time-sensitive scientific experiments into the hands of researchers just a few hours after leaving orbit. It was a valuable service that simply didn’t exist before the Shuttle, and one that scientists have been deprived of ever since its retirement.

Until now. With the successful splashdown of the first Cargo Dragon 2 off the coast of Florida, NASA is one step closer to regaining a critical capability it hasn’t had for a decade. While it’s still not quite as convenient as simply rolling the Shuttle into the Orbiter Processing Facility after a mission, the fact that SpaceX can guide their capsule down into the waters near the Space Coast greatly reduces the time required to return experiments to the researchers who designed them.

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The $50 Ham: A Cheap Antenna For The HF Bands

January 19, 2021 by Dan Maloney 65 Comments

So far in the $50 Ham series, I’ve concentrated mainly on the VHF and UHF bands. The reason for this has to do mainly with FCC rules, which largely restrict Technician-level licensees to those bands. But there’s a financial component to it, too; high-frequency (HF) band privileges come both at the price of learning enough about radio to pass the General license test, as well as the need for gear that can be orders of magnitude more expensive than a $30 handy-talkie radio.

But while HF gear can be expensive, not everything needed to get on the air has to be so. And since it’s often the antenna that makes or breaks an amateur radio operator’s ability to make contacts, we’ll look at a simple but versatile antenna design that can be adapted to support everything from a big, powerful base station to portable QRP (low-power) activations in the field: the end-fed half-wave antenna.

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TV Detector Vans Once Prowled The Streets Of England

January 18, 2021 by Lewin Day 307 Comments

The United Kingdom is somewhat unique in the world for requiring those households which view broadcast television to purchase a licence for the privilege. Initially coming into being with the Wireless Telegraphy Act in 1923, the licence was required for anyone receiving broadcast radio, before being expanded to cover television in 1946. The funds generated from this endeavour are used as the primary funding for the British Broadcasting Corporation.

A typical TV licence invoice. Separate licences for black and white and color sets still exist, with 6000 B&W licences issued in 2019.

Of course, it’s all well and good to require a licence, but without some manner of enforcement, the measure doesn’t have any teeth. Among other measures, the BBC have gone as far as employing special vans to hunt down illegally operating televisions and protect its precious income.

The Van Is Coming For You

To ensure a regular income, the BBC runs enforcement operations under the TV Licencing trade name, the entity which is responsible for administering the system. Records are kept of licences and their expiry dates, and investigations are made into households suspected of owning a television who have not paid the requisite fees. To encourage compliance, TV Licencing regularly sends sternly worded letters to those who have let their licence lapse or have not purchased one. In the event this fails, they may arrange a visit from enforcement officers. These officers aren’t empowered to forcibly enter homes, so in the event a homeowner declines to cooperate with an investigation, TV Licencing will apply for a search warrant. This may be on the basis of evidence such as a satellite dish or antenna spotted on the roof of a dwelling, or a remote spied on a couch cushion through a window.

Alternatively, a search warrant may be granted on the basis of evidence gleaned from a TV detector van. Outfitted with equipment to detect a TV set in use, the vans roam the streets of the United Kingdom, often dispatched to addresses with lapsed or absent TV licences. If the van detects that a set may be operating and receiving broadcast signals, TV Licencing can apply to the court for the requisite warrant to take the investigation further. The vans are almost solely used to support warrant applications; the detection van evidence is rarely if ever used in court to prosecute a licence evader. With a warrant in hand, officers will use direct evidence such as a television found plugged into an aerial to bring an evader to justice through the courts.

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NVMe Blurs The Lines Between Memory And Storage

January 13, 2021 by Maya Posch 50 Comments

The history of storage devices is quite literally a race between the medium and the computing power as the bottleneck of preserving billions of ones and zeros stands in the way of computing nirvana. The most recent player is the Non-Volatile Memory Express (NVMe), something of a hybrid of what has come before.

The first generations of home computers used floppy disk and compact cassette-based storage, but gradually, larger and faster storage became important as personal computers grew in capabilities. By the 1990s hard drive-based storage had become commonplace, allowing many megabytes and ultimately gigabytes of data to be stored. This would drive up the need for a faster link between storage and the rest of the system, which up to that point had largely used the ATA interface in Programmed Input-Output (PIO) mode.

This led to the use of DMA-based transfers (UDMA interface, also called Ultra ATA and Parallel ATA), along with DMA-based SCSI interfaces over on the Apple and mostly server side of the computer fence. Ultimately Parallel ATA became Serial ATA (SATA) and Parallel SCSI became Serial Attached SCSI (SAS), with SATA being used primarily in laptops and desktop systems until the arrival of NVMe along with solid-state storage.

All of these interfaces were designed to keep up with the attached storage devices, yet NVMe is a bit of an odd duck considering the way it is integrated in the system. NVMe is also different for not being bound to a single interface or connector, which can be confusing. Who can keep M.2 and U.2 apart, let alone which protocol the interface speaks, be it SATA or NVMe?

Let’s take an in-depth look at the wonderful and wacky world of NVMe, shall we?

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