Tech In Plain Sight: Glucose Meters

If you or someone you know is diabetic, it is a good bet that a glucose meter is a regular fixture in your life. They are cheap and plentiful, but they are actually reasonably high tech — well, at least parts of them are.

The meters themselves don’t seem like much, but that’s misleading. A battery, a few parts, a display, and enough of a controller to do things like remember readings appears to cover it all. You wouldn’t be surprised, of course, that you can get the whole affair “on a chip.” But it turns out, the real magic is in the test strip and getting a good reading from a strip requires more metrology than you would think. A common meter requires a precise current measurement down to 10nA. The reading has to be adjusted for temperature, too. The device is surprisingly complex for something that looks like a near-disposable piece of consumer gear.

Of course, there are announcements all the time about new technology that won’t require a needle stick. So far, none of those have really caught on for one reason or another, but that, of course, could change. GlucoWatch G2, for example, was a watch that could read blood glucose, but — apparently — was unable to cope with perspiration.

Even the meters that continuously monitor still work in more or less the same way as the cheap meters. As Hackaday’s Dan Maloney detailed a few years back, continuous glucose monitors leave a tiny sensor under your skin and measure fluid in your body, not necessarily blood. But the way the sensor works is usually the same.

For the purposes of this article, I’m only going to talk about the traditional meter: you insert a test strip, prick your finger, and let the test strip soak up a little bit of blood.

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Electronic Covid Test Tear Down Shows Frustrating Example Of 1-Time-Use Waste

The latest video from [TheSignalPath] is a result of his purchase of a home COVID-19 test. He found an electronic version that connects to your cell phone and displays the results on the phone. The device is an antigen test and, internally, works like the home tests that show the results using lines similar to a pregnancy test. So, somehow, the phone version reads the lines and communicates with the phone. But how? That’s the point of the video, which you can see below.

In a traditional test, there’s a control line that has to appear to show that the test was done correctly. Then a line under that indicates detection of the virus. The circuit board inside the electronic test has a plastic unit onboard that contains a similar strip and has optical sensors for both the reference line and the detection line. Since it is essentially an optical device — there are some lenses in the strip assembly that look like they are detecting the dye as it moves through the strip with LEDs onboard to shed light on the situation.

Under the microscope, the CPU is a typical Bluetooth-capable ARM chip from Nordic. The board did power up, but the device is made to only operate once because of the test strip. The video notes — and we agree — it seems wasteful to create an entire Bluetooth-enabled microcontroller board with optical components just to read a strip one time that is pretty easy to read to start with. We’ll stick with the simple test strip. Still, it is interesting to see the insides.

If you want to read more about antigen tests, we covered that. We also talked about PCR testing.

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3D Printing Toothpaste In The Name Of Science

While we don’t often see them in the hobbyist community, 3D printers that can extrude gels and viscous liquids have existed commercially for years, and are increasingly used for biological research. [Ahron Wayne] has recently been working with such a printer as part of a project to develop a printed wound dressing made of honey and blood clotting proteins, but for practice purposes, wanted to find a cheaper and more common material that had similar extrusion properties.

The material he settled on ended up being common toothpaste. In the video below you can see him loading up the cartridge of a CELLINK INKREDIBLE+ bioprinter with the minty goop, which is then extruded through a thin blunt-tip needle by compressed air. After printing out various shapes and words using the material, often times directly onto the bristles of a toothbrush, he’s come up with a list of tips for printing similarly viscous substances.

First and foremost, go slow. [Ahron] says the material needs a moment to contract after being extruded if it’s going to have any hope of supporting the next layer of the print. Thick layer heights are a necessity, as is avoiding sharp curves in your design. He also notes that overhangs must be avoided, and though it probably goes without saying, clarifies that an object printed from toothpaste will never be able to support anything more than its own weight.

In addition to the handful of legitimate DIY bioprinters that have graced these pages over the years, we’ve seen the occasional chocolate 3D printer that operated on a similar principle to produce bespoke treats, so the lessons learned by [Ahron] aren’t completely lost on the hacker and maker crowd. Who knows? Perhaps you’ll one day find yourself consulting this video when trying to get a modified 3D printer to lay down some soldering paste.

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A shirt with carbon nanotube threads stitched into a shirt monitor the wearer's heart rate.

Sew-able Carbon Nanotube Thread Could Spin A Lot Of Awesome

Plenty of people just plain dislike wearing jewelry, even (or especially) smart watches. Nevertheless, they’d like to have biofeedback like everybody else. Well, we watch-less ones have something to look forward to, because a group of graduate students at Rice University have created extremely strong conductive thread woven from carbon nanotubes, which can be sewn into standard athletic clothing and used as electrodes, antennas, or simply as ballistic protection.

At 22 microns wide, the original carbon nanotubes were too skinny to use as thread. Instead, the team braided together three bundles of seven ‘tubes each using the type of machine that model boat builders use to make tiny rigging. Then they zig-zag stitched the threads into a shirt, which gives the stitches added flexibility. This thread maybe as strong and conductive as metal, but the fibers are soft and flexible, and most importantly, machine-washable. Between its strength and conductivity, this thread could have a long list of applications from military down to civilian. Check out the introduction in the video after the break.

For now, the shirt has to be pretty snug, but future garments could easily have higher concentrations of nano-threads in order to get a better signal. Good thing, because we’re still carrying around our COVID nineteen — aka the weight we’ve gained since the longest March of anyone’s life, and never liked tight shirts anyway.

What else can carbon nanotubes do? Plenty, like keep 3D prints from delaminating.

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A Raspberry Pi-based COVID Green Pass validator verifies a QR code on a phone.

COVID Green Pass Validator With Raspberry Pi

It seems like every nation is dealing with the plague a little differently. In June, the EU instated a COVID Green Pass which comes in the form of a paper or digital QR code. It was designed to grease the wheels of travel throughout Europe and allow access to nursing homes. As of early August, the Green Pass is now required of those 12 and older in Italy to gain access to bars and restaurants, museums, theaters, etc. — anywhere people gather in sizeable groups. The Green Pass shows that you’ve either been vaccinated, have had COVID and recovered, or you have tested negative, and there are different half-lives for each condition: nine months for vaccinated, six for recovered, and just forty-eight hours for a negative test.

[Luca Dentella] has built a Green Pass validator using a Raspberry Pi and a Raspi camera. Actual validation must be done through the official app, so this project is merely for educational purposes. Here’s how it works: the user data including their status and the date/time of pass issuance are encoded into a JSON file, then into CBOR, then it is digitally signed for authenticity. After that, the information is zipped up into a base-45 string, which gets represented as a QR code on your phone. Fortunately, [Luca] found the Minister of Health’s GitHub, which does the hard work of re-inflating the JSON object.

[Luca]’s Pi camera reads in the QR and does complete validation using two apps — a camera client written in Python that finds QRs and sends them to the validation server, written in Node.js. The validation server does formal verification including verifying the signature and the business rules (e.g. has it been more than 48 hours since Karen tested negative?) Fail any of these and the red LED lights up; pass them all and you get the green light. Demo video is after the break.

Are you Canadian? Then check this out, eh?

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Mechanisms Behind Vaccine Side-Effects: The Science That Causes That Sore Arm

After receiving a vaccination shot, it’s likely that we’ll feel some side-effects. These can range from merely a sore arm to swollen lymph nodes and even a fever. Which side-effects to expect depend on the exact vaccine, with each type and variant coming with its own list of common side-effects. Each person’s immune system will also react differently, which makes it hard to say exactly what one can expect after receiving the vaccination.

What we can do is look closer at the underlying mechanisms that cause these side-effects, to try and understand why they occur and how to best deal with them. Most relevant here for the initial response is the body’s innate immune system, with dendritic cells generally being among the first to come into contact with the vaccine and to present the antigen to the body’s adaptive immune system.

Key to the redness, swelling, and fever are substances produced by the body which include various cytokines as well as prostaglandin, producing the symptoms seen with inflammation and injury.

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Hacking When It Counts: Surgery Fit To Save A Future King

When we picture the Medieval world, it conjures up images of darkness, privations, and sickness the likes of which are hard to imagine from our sanitized point of view. The 1400s, and indeed the entirety of history prior to the introduction of antibiotics in the 1940s, was a time when the merest scratch acquired in the business of everyday life could lead to an infection ending in a slow, painful death. Add in the challenges of war, where violent men wielding sharp things on a filthy field of combat, and it’s a wonder people survived at all.

But then as now, some people are luckier than others, and surviving what even today would likely be a fatal injury was not unknown, as one sixteen-year-old boy in 1403 would discover. It didn’t hurt that he was the son of the king of England, and when he earned an arrow in his face in combat, every effort would be made to save the prince and heir to the throne. It also helped that he had the good fortune to have a surgeon with the imagination to solve the problem, and the skill to build a tool to help.

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