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Angry antibodies

Monoclonal Antibodies: The Guided Missiles Of Medicine

September 15, 2021 by 11 Comments

Whenever anyone mentions the word “antibodies” these days, it’s sure to grab your attention. Thoughts generally flow to the human immune system and the role it plays in the ongoing COVID-19 pandemic, and to how our bodies fight off disease in general. The immune system is complex in the extreme, but pretty much everyone knows that antibodies are part of it and that they’re vital to the ability of the body to recognize and neutralize invaders like bacteria and viruses.

But as important as antibodies are to long-term immunity and the avoidance of disease, that’s far from all they’re good for. The incredible specificity of antibodies to their target antigens makes them powerful tools for biological research and clinical diagnostics, like rapid COVID-19 testing. The specificity of antibodies has also opened up therapeutic modalities that were once the stuff of science-fiction, where custom-built antibodies act like a guided missile to directly attack not only a specific protein in the body, but sometimes even a specific part of a protein.

Making these therapies work, though, requires special antibodies: monoclonal antibodies. These are very much in the news recently, not only as a possible treatment for COVID-19 but also to treat everything from rheumatoid arthritis to the very worst forms of cancer. But what exactly are monoclonal antibodies, how are they made, and how do they work?

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A bee pollinates a flower.

Even Bees Are Abuzz About Caffeine

September 13, 2021 by 33 Comments

Many of us can’t get through the day without at minimum one cup of coffee, or at least, we’d rather not think about trying. No matter how you choose to ingest caffeine, it is an awesome source of energy and focus for legions of hackers and humans. And evidently, the same goes for pollinator bees.

You’ve probably heard that there aren’t enough bees around anymore to pollinate all the crops that need pollinating. That’s old news. One solution was to raise them commercially and then truck them to farmers’ fields where they’re needed. The new problem is that the bees wander off and pollinate wildflowers instead of the fields they’re supposed to be pollinating. But there’s hope for these distracted bees: Scientists at the University of Greenwich have discovered that bees under the influence of caffeine are more likely to stay on track when given a whiff of the flower they’re supposed to be pollinating.

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Pinning Tails On Satellites To Help Prevent Space Junk

September 13, 2021 by 32 Comments

Low Earth orbit was already relatively crowded when only the big players were launching satellites, but as access to space has gotten cheaper, more and more pieces of hardware have started whizzing around overhead. SpaceX alone has launched nearly 1,800 individual satellites as part of its Starlink network since 2019, and could loft as many as 40,000 more in the coming decades. They aren’t alone, either. While their ambitions might not be nearly as grand, companies such as Amazon and Samsung have announced plans to create satellite “mega-constellations” of their own in the near future.

At least on paper, there’s plenty of room for everyone. But what about when things go wrong? Should a satellite fail and become unresponsive, it’s no longer able to maneuver its way out of close calls with other objects in orbit. This is an especially troubling scenario as not everything in orbit around the Earth has the ability to move itself in the first place. Should two of these uncontrollable objects find themselves on a collision course, there’s nothing we can do on the ground but watch and hope for the best. The resulting hypervelocity impact can send shrapnel and debris flying for hundreds or even thousands of kilometers in all three dimensions, creating an extremely hazardous situation for other vehicles.

One way to mitigate the problem is to design satellites in such a way that they will quickly reenter the Earth’s atmosphere and burn up at the end of their mission. Ideally, the deorbit procedure could even activate automatically if the vehicle became unresponsive or suffered some serious malfunction. Naturally, to foster as wide adoption as possible, such a system would have to be cheap, lightweight, simple to integrate into arbitrary spacecraft designs, and as reliable as possible. A tall order, to be sure.

But perhaps not an impossible one. Boeing subsidiary Millennium Space Systems recently announced it had successfully deployed a promising deorbiting device developed by Tethers Unlimited. Known as the Terminator Tape, the compact unit is designed to rapidly slow down an orbiting satellite by increasing the amount of drag it experiences in the wispy upper atmosphere.

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NASA Are Squaring Up Against The Asteroid Threat

September 10, 2021 by 43 Comments

The world faces many terrestrial crises right now, so it’s easy to forget that giant space rocks may one day threaten the very existence of entire civilizations. Yes, the threat of asteroid strikes is a remote one, but nevertheless something humanity may have to face one day, and one day soon.

NASA takes the issue seriously, and has staffed its Planetary Defence Coordination Office since 2016. In service to these efforts, it’s also developing a mission to research how dangerous androids may be deflected. The Double Asteroid Redirection Test, or DART, is set to launch within the next year. Continue reading “NASA Are Squaring Up Against The Asteroid Threat” →

Books You Should Read: Bil Herd’s Back Into The Storm

September 8, 2021 by 27 Comments

It’s a morning ritual that we guess most of you share with us; before whatever work a new day will bring to sit down with a coffee and catch up with the tech news of the moment on Hackaday and other sites. Most of us don’t do many exciting things in our everyday lives, so reading about the coolest projects and the most fascinating new developments provides us with interest and motivation. Imagine just for a moment then that by a twist of fate you found yourself taking a job at the epicentre of the tech that is changing the world,  producing the objects of desire and pushing the boundaries, the place you’d give anything to work at.

This is the premise behind our Hackaday colleague Bil Herd’s autobiographical chronicle of time in the mid 1980s during which he worked at Commodore, maker of some of the most iconic home computers of the day. We follow him through the three years from 1983 to 1986 as hardware lead on the “TED” series of computers including the Commodore 16 and Plus/4, and then the Commodore 128, a dual-processor powerhouse which was arguably the last of the big-selling 8-bit home computers.

It’s an intertwined set of narratives peppered with personal anecdotes; of the slightly crazy high-pressure world of consumer videogames and computing, the fine details of designing a range of 8-bit machines, and a fascinating insight into how the culture at Commodore changed in the period following the departure of its founder Jack Tramiel.

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The Dark Side Of Package Repositories: Ownership Drama And Malware

September 8, 2021 by 77 Comments

At their core, package repositories sound like a dream: with a simple command one gains access to countless pieces of software, libraries and more to make using an operating system or developing software a snap. Yet the rather obvious flip side to this is that someone has to maintain all of these packages, and those who make use of the repository have to put their faith in that whatever their package manager fetches from the repository is what they intended to obtain.

How ownership of a package in such a repository is managed depends on the specific software repository, with the especially well-known JavaScript repository NPM having suffered regular PR disasters on account of it playing things loose and fast with package ownership. Quite recently an auto-transfer of ownership feature of NPM was quietly taken out back and erased after Andrew Sampson had a run-in with it painfully backfiring.

In short, who can tell when a package is truly ‘abandoned’, guarantee that a package is free from malware, and how does one begin to provide insurance against a package being pulled and half the internet collapsing along with it?

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New Engines Could Propel The B-52 Beyond Its 100th Birthday

September 7, 2021 by 87 Comments

First taking to the skies in April 1952, and introduced into the US Air Force in 1955, the B-52 Stratofortress has since become a mainstay of American air power. Originally developed as a nuclear bomber to carry out the critical deterrence role, changing realities saw it delivering solely conventional munitions in actual operations.

Of 744 B-52s originally built, 76 remain in service with the Air Force and Air Force Reserve. This fleet is set to go on flying beyond the type’s 100th birthday, into 2050 and beyond. To reach that milestone, a new engine package will be key to keeping these birds in the air.

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