Emmanuelle Charpentier And Jennifer Doudna Sharpened Mother Nature’s Genetic Scissors And Won The Nobel For It

November 3, 2020 by Kristina Panos 8 Comments

It sounds like science fiction — and until 2012, the ability to cheaply and easily edit strings of DNA was exactly that. But as it turns out, CRISPR/Cas9 gene editing is a completely natural function in which bacteria catalogs its interactions with viruses by taking a snippet of the virus’ genetic material and filing it away for later.

Now, two women have won the 2020 Nobel Prize in Chemistry “for developing a method for genome editing”. Emmanuelle Charpentier and Jennifer Doudna leveraged CRISPR into a pair of genetic scissors and showed how sharp they are by proving that they can edit any string of DNA this way. Since Emmanuelle and Jennifer published their 2012 paper on CRISPR/Cas9, researchers have used these genetic scissors to create drought-resistant plants and look for new gene-based cancer therapies. Researchers are also hoping to use CRISPR/Cas9 to cure inherited diseases like Huntington’s and sickle cell anemia.

The discovery started with Emmanuelle Charpentier’s investigation of the Streptococcus pyogenes bacterium. She was trying to understand how its genes are regulated and was hoping to make an antibiotic. Once she teamed up with Jennifer Doudna, they found a scientific breakthrough instead.

Dr. Emmanuelle Charpentier via Wikimedia Commons

Emmanuelle Charpentier Fights Flesh-Eating Bacteria

Emmanuelle Charpentier was born December 11th, 1968 in Juvisy-sur-Orge, France. She studied biochemistry, microbiology, and genetics at the Pierre and Marie Curie University, which is now known as Sorbonne University. Then she received a research doctorate from Institut Pasteur and worked as a university teaching assistant and research scientist. Dr. Charpentier is currently a director at the Max Planck Institute for Infection Biology in Berlin, and in 2018, she founded an independent research unit.

Upon completion of her doctorate, Dr. Charpentier spent a few years working in the States before winding up at the University of Vienna where she started a research group. Her focus was still on the bacteria Streptococcus pyogenes, which causes millions of people to suffer through infections like tonsillitis and impetigo each year. It also causes sepsis, which officially makes it a flesh-eating bacterium.

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As Facebook Tightens Their Grip On VR, Jailbreaking Looks More Likely

November 3, 2020 by Donald Papp 57 Comments

The Quest 2 wireless VR headset by Oculus was recently released, and improves on the one-and-a-half year old Quest mainly in terms of computing power and screen resolution. But Oculus is owned by Facebook, a fact that Facebook is increasingly keen on making very clear. The emerging scene is one that looks familiar: a successful hardware device, and a manufacturer that wants to keep users in a walled garden while fully controlling how the device can be used. Oculus started out very differently, but the writing has been on the wall for a while. Rooting and jailbreaking the Quest 2 seems inevitable, but what will happen then? Continue reading “As Facebook Tightens Their Grip On VR, Jailbreaking Looks More Likely” →

Engine Trouble Delays SpaceX’s Return To The ISS

October 27, 2020 by Tom Nardi 20 Comments

A crewed mission to the International Space Station that was set to depart from Kennedy Space Center on Halloween has been pushed back at least several weeks as NASA and SpaceX investigate an issue with the company’s Merlin rocket engine. But the problem in question wasn’t actually discovered on the booster that’s slated to carry the four new crew members up to the orbiting outpost. This story starts back on October 2nd, when the computer aboard a Falcon 9 set to carry a next-generation GPS III satellite into orbit for the US Space Force shut down the engines with just two seconds to go before liftoff.

The fact that SpaceX and NASA have decided to push back the launch of a different Falcon 9 is a clear indication that the issue isn’t limited to just one specific booster, and must be a problem with the design or construction of the Merlin engine itself. While both entities have been relatively tight lipped about the current situation, a Tweet from CEO Elon Musk made just hours after the GPS III abort hinted the problem was with the engine’s gas generator:

As we’ve discussed previously, the Merlin is what’s known as an “open cycle” rocket engine. In this classical design, which dates back to the German V-2 of WWII, the exhaust from what’s essentially a smaller and less efficient rocket engine is used to spin a turbine and generate the power required to pump the propellants into the main combustion chamber. Higher than expected pressure in the gas generator could lead to a catastrophic failure of the turbine it drives, so it’s no surprise that the Falcon 9’s onboard systems determined an abort was in order.

Grounding an entire fleet of rockets because a potentially serious fault has been discovered in one of them is a rational precaution, and has been done many times before. Engineers need time to investigate the issue and determine if changes must be made on the rest of the vehicles before they can safely return to flight. But that’s where things get interesting in this case.

SpaceX hasn’t grounded their entire fleet of Falcon 9 rockets. In fact, the company has flown several of them since the October 2nd launch abort. So why are only some of these boosters stuck in their hangers, while others are continuing to fly their scheduled missions?

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Tesla Begins “Full Self Driving” Public Beta As Waymo And Cruise Go Unattended

October 23, 2020 by Lewin Day 131 Comments

Self-driving technology is a holy grail that promises to forever change the way we interact with cars. Thus far, there’s been plenty of hype and excitement, but full vehicles that remove the driver from the equation have remained far off. Tesla have long posited themselves as a market leader in this area, with their Autopilot technology allowing some limited autonomy on select highways. However, in a recent announcement, they have heralded the arrival of a new “Full Self Driving” ability for select beta testers in their early access program.

Taking Things Up A Notch

Telsa’s update notes highlight the new “Full Self-Driving” capabilities. Drivers are expected to pay continuous attention and be prepared to take over at any time, as the system “may do the wrong thing at the worst time.”

The new software update further extends the capabilities of Tesla vehicles to drive semi-autonomously. Despite the boastful “Full Self Driving” moniker, or FSD for short, it’s still classified as a Level 2 driving automation system, which relies on human intervention as a backup. This means that the driver must be paying attention and ready to take over in an instant, at all times. Users are instructed to keep their hands on the wheel at all times, but predictably, videos have already surfaced of users ignoring this measure.

The major difference between FSD and the previous Autopilot software is the ability to navigate city streets. Formerly, Tesla vehicles were only able to self-drive on highways, where the more regular flow of traffic is easier to handle. City streets introduce far greater complexity, with hazards like parked cars, pedestrians, bicycles, and complicated intersections. Unlike others in the field, who are investing heavily in LIDAR technology, Tesla’s system relies entirely on cameras and radar to navigate the world around it. Continue reading “Tesla Begins “Full Self Driving” Public Beta As Waymo And Cruise Go Unattended” →

Ethernet At 40: From A Napkin Sketch To Multi-Gigabit Links

October 19, 2020 by Maya Posch 50 Comments

September 30th, 1980 is the day when Ethernet was first commercially introduced, making it exactly forty years ago this year. It was first defined in a patent filed by Xerox as a 10 Mb/s networking protocol in 1975, introduced to the market in 1980 and subsequently standardized in 1983 by the IEEE as IEEE 802.3. Over the next thirty-seven years, this standard would see numerous updates and revisions.

Included in the present Ethernet standard are not just the different speed grades from the original 10 Mbit/s to today’s maximum 400 Gb/s speeds, but also the countless changes to the core protocol to enable these ever higher data rates, not to mention new applications of Ethernet such as power delivery and backplane routing. The reliability and cost-effectiveness of Ethernet would result in the 1990 10BASE-T Ethernet standard (802.3i-1990) that gradually found itself implemented on desktop PCs.

With Ethernet these days being as present as the presumed luminiferous aether that it was named after, this seems like a good point to look at what made Ethernet so different from other solutions, and what changes it had to undergo to keep up with the demands of an ever-more interconnected world. Continue reading “Ethernet At 40: From A Napkin Sketch To Multi-Gigabit Links” →

Welcome To Solar Cycle 25; Our Sun Enters A New 11-Year Period

October 6, 2020 by Dan Maloney 45 Comments

Most of us perceive time as an arrow, a one-way trip into the future. And while that’s true, nature has a way of interpolating circular patterns onto that linear model — day follows night, the seasons progress through the year, and generations are born, live, and die after creating the next generation to do experience the same cycles in the future.

Our star, too, follows this cyclical model, and goes through observable, periodic changes that are of keen interest to solar scientists. So it was with some fanfare that they recently announced that the sun had transitioned into Solar Cycle 25. But what exactly does that mean? Does the Sun’s changing face make much difference to the average person’s daily life? History shows that it can, so it pays to know what we’re in store for over the next couple of decades. Welcome to your primer on Solar Cycle 25.

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Tesla’s New Tabless Batteries Unlock New Levels Of Performance

October 5, 2020 by Lewin Day 104 Comments

Telsa are one of the world’s biggest purchasers of batteries through their partnerships with manufacturers like Panasonic, LG and CATL. Their endless hunger for more cells is unlikely to be satiated anytime soon, as demand for electric cars and power storage continues to rise.

As announced at their Battery Day keynote, Tesla has been working hard on a broad spectrum of projects to take battery technology to the next level in order to reach their goal of 3 TWh annual production by 2030. One of the most interesting aspects of this was the announcement of Tesla’s new tabless 4680 battery, which will be manufactured by the company itself. Let’s take a look at what makes the 4680 so exciting, and why going tabless is such a big deal. Continue reading “Tesla’s New Tabless Batteries Unlock New Levels Of Performance” →