Emmanuelle Charpentier And Jennifer Doudna Sharpened Mother Nature’s Genetic Scissors And Won The Nobel For It

November 3, 2020 by Kristina Panos 8 Comments

It sounds like science fiction — and until 2012, the ability to cheaply and easily edit strings of DNA was exactly that. But as it turns out, CRISPR/Cas9 gene editing is a completely natural function in which bacteria catalogs its interactions with viruses by taking a snippet of the virus’ genetic material and filing it away for later.

Now, two women have won the 2020 Nobel Prize in Chemistry “for developing a method for genome editing”. Emmanuelle Charpentier and Jennifer Doudna leveraged CRISPR into a pair of genetic scissors and showed how sharp they are by proving that they can edit any string of DNA this way. Since Emmanuelle and Jennifer published their 2012 paper on CRISPR/Cas9, researchers have used these genetic scissors to create drought-resistant plants and look for new gene-based cancer therapies. Researchers are also hoping to use CRISPR/Cas9 to cure inherited diseases like Huntington’s and sickle cell anemia.

The discovery started with Emmanuelle Charpentier’s investigation of the Streptococcus pyogenes bacterium. She was trying to understand how its genes are regulated and was hoping to make an antibiotic. Once she teamed up with Jennifer Doudna, they found a scientific breakthrough instead.

Dr. Emmanuelle Charpentier via Wikimedia Commons

Emmanuelle Charpentier Fights Flesh-Eating Bacteria

Emmanuelle Charpentier was born December 11th, 1968 in Juvisy-sur-Orge, France. She studied biochemistry, microbiology, and genetics at the Pierre and Marie Curie University, which is now known as Sorbonne University. Then she received a research doctorate from Institut Pasteur and worked as a university teaching assistant and research scientist. Dr. Charpentier is currently a director at the Max Planck Institute for Infection Biology in Berlin, and in 2018, she founded an independent research unit.

Upon completion of her doctorate, Dr. Charpentier spent a few years working in the States before winding up at the University of Vienna where she started a research group. Her focus was still on the bacteria Streptococcus pyogenes, which causes millions of people to suffer through infections like tonsillitis and impetigo each year. It also causes sepsis, which officially makes it a flesh-eating bacterium.

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Shocking Tinnitus Therapy Is Music To Sufferers’ Ears

October 16, 2020 by Kristina Panos 67 Comments

Do you suffer from tinnitus? We were surprised to learn that 15-20% of people have this condition that amounts to constant ringing in the ears. Science doesn’t fully understand the ringing part, but one possible explanation is that the brain is compensating for the frequencies it can’t hear any more.

[Hubert Lim], a biomedical engineer at the University of Minnesota discovered that the brain can be stimulated to the point of suppressing tinnitus for as long as one year. [Lim] discovered this by accident while doing deep brain stimulation on a patient with tinnitus. The electrode strayed a bit, touching other areas of the brain and the patient suddenly exclaimed that they couldn’t hear their tinnitus anymore.

Then [Lim] and his team tested guinea pigs, searching here, there, and under the armpits for the best place to suppress tinnitus. As it turns out, the tongue is one of the best places when used along with a specific soundscape. So then they did a human trial with 326 people. Each person had a small paddle electrode on their tongue and headphones on their ears.

As the electrodes sparkled like Pop Rocks against their tongues, the trial participants listened to pure frequencies played over a background of sound resembling vaporwave music. The combination of the two overstimulates the brain, forcing it to suppress the tinnitus reaction. This discovery certainly seems like a game changer for tinnitus sufferers. If we had tinnitus, we would be first in line to try this out given the chance. Armed with the soundscape, we’re left to wonder how many 9V batteries we’d have to lick to approximate the paddle.

Speaking of taste, have you ever experienced all five at once? Here’s a device that simulates them all.

DIY Braille Embosser Is Really Impressive

October 10, 2020 by Kristina Panos 21 Comments

We weren’t surprised to learn that Braille tools are quite expensive. But it’s interesting to hear that there’s another class of tools altogether, and they are very cheap and imprecise. In devising the Braille Embossing Experience, aka BEE, [alatorre] sought to find an open-source middle ground. We think they succeeded marvelously.

Another surprising thing — while handheld embossers do exist, there is no system for filling out an A4 sheet of paper, say, to write a letter.

For Braille to be readable, the characters and lines must be properly spaced, and this requires some kind of moveable type-like device to correctly register the characters onto paper. BEE fills this void as well. The amazing thing is, there’s not much more to it than a marked-up piece of aluminum and some clever 3D printing.

There are two parts to this system — the positioning rail, which includes a landing box for the embosser with six holes in the bottom. The other part is a pair of embossers, one for letters A-M, and another for letters N-Z. To use BEE, just slide the rail to the right and start embossing letters right to left, then flip the paper over when finished.

Need to create something more permanent? Make a Braille PCB.

Keep Your YouTube Habits To Yourself With FreeTube

October 7, 2020 by Sven Gregori 43 Comments

If your usual YouTube viewing selection covers a wild and random variety of music, tech subjects, cooking, history, and anything in-between, you will sooner or later be baffled by some of the “Recommended for you” videos showing up. When it features a ten-hour mix of Soviet propaganda choir music, you might start wondering what a world taken over by an artificial intelligence might actually look like, and realize that your browser’s incognito / private mode really isn’t just for shopping birthday presents in secret. Things get a bit tricky if you actually enjoy or even rely on the whole subscribing-to-channels concept though, which is naturally difficult to bring in line with privacy in today’s world of user-data-driven business models.

Entering the conversation: the FreeTube project, a cross-platform application whose mission is to regain privacy and put the control of one’s data back into the user’s hands. Bypassing YouTube and its player, the watch history and subscriptions — which are still possible — are kept only locally on your own computer, and you can import either of them from YouTube and export them to use within FreeTube on another device (or back to YouTube). Even better, it won’t load a video’s comments without explicitly telling it to, and of course it keeps out the ads as well.

Originally, the Invidious API was used to get the content, and is still supported as fallback option, but FreeTube comes with its own extractor API nowadays. All source code is available from the project’s GitHub repository, along with pre-built packages for Linux (including ARM), Windows, and Mac. The application itself is created using Electron, which might raise a few eyebrows as it packs an entire browser rendering engine and essentially just disguises a website as standalone application. But as the FAQ addresses, this allows easy cross-platform support and helps the project, which would have otherwise been Linux-only, to reach as many people as possible. That’s a valid point in our book.

Keep in mind though, FreeTube is only a player, and more of a wrapper around YouTube itself, so YouTube will still see your IP and interaction with the service. If you want to be fully anonymous, this isn’t a silver bullet and will require additional steps like using a VPN. Unlike other services that you could replace with a local alternative to avoid tracking and profiling, content services are just a bit trickier if you want to actually have a useful selection. So this is a great compromise that also just works out of the box for everyone regardless of their technical background. Let’s just hope it won’t break too much next time some API changes.

Cleaning Up The Yard With AI — Avian Intelligence

October 4, 2020 by Dan Maloney 28 Comments

Despite epithets like “bird-brain,” our feathered friends are actually pretty smart. Being able to maneuver in three dimensions at high speed must have something to do with it, and the cognitive abilities of birds are well-documented and still being researched. So it naturally makes sense to harness avian brainpower to keep one’s yard clean, right?

For the record, the magpies that [Hans] is training are very intelligent and strikingly beautiful birds who delight in swooping down to harass people, and who will gladly steal food from other birds and then poop on it and fly away. So they’re jerks, but that doesn’t mean they can’t be useful jerks. The goal with his BirdBox system is to use classic operant conditioning, where a desired voluntary behavior is reinforced by a reward. In this case, the reward is a treat dispensed by a 3D-printed vibratory dispenser when the bird collects a bottlecap from the yard and deposits it in the proper slot. The video below shows the birds doing exactly what they’re supposed to do.

[Hans] tells us that the trick is getting the birds to accept the BirdBox and to have them integrate it into their “patrol schematic” of their territory. Once that’s done, it’s a simpler matter to have them associate the bottlecaps with the reward. The other challenge is making everything bulletproof, or in this case magpie-proof. Did we mention that magpies are jerks?

The possibilities for trading peanuts for yardwork are endless; [Hans] mentions plans he has for fallen fruit clean-up, and mentions a persistent garden slug problem that the birds might be employed to remediate. If you want to try this, it might be a good idea to brush up on the work of [B.F. Skinner] and his pigeons of war.

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Parking Assistant Helps Back Up The Car Without Going Too Far

September 27, 2020 by Kristina Panos 24 Comments

Sure, [Ty Palowski] could have just hung a tennis ball from the ceiling, but that would mean getting on a ladder, testing the studfinder on himself before locating a ceiling joist, and so on. Bo-ring. Now that he finally has a garage, he’s not going to fill it with junk, no! He’s going to park a big ol’ Jeep in it. Backwards.

The previous owner was kind enough to leave a workbench in the rear of the garage, which [Ty] has already made his own. To make sure that he never hits the workbench while backing into the garage, [Ty] made an adorable stoplight to help gauge the distance to it. Green mean’s he’s good, yellow means he should be braking, and red of course means stop in the name of power tools.

Inside the light is an Arduino Nano, which reads from the ultrasonic sensor mounted underneath the enclosure and lights up the appropriate LED depending on the car’s distance. All [Ty] has to do is set the distance that makes the red light come on, which he can do with the rotary encoder on the side and confirm on the OLED. The distance for yellow and green are automatically set from red — the yellow range begins 24″ past red, and green is another 48″ past yellow. Floor it past the break to watch the build video.

The humble North American traffic signal is widely recognized, so it’s a good approach for all kinds of applications. Teach your children well: start them young with a visual indicator of when it’s okay to get out of bed in the morning.

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Plastic Prosthetics For Rubber Duckies

September 19, 2020 by Elliot Williams 14 Comments

Will someone please think of the rubber duckies?!

For decades they’ve been reduced to a laughing stock: a caricature of waterfowl. Left without a leg to stand on, their only option is to float around in the tub. And they don’t even do that well, lacking the feet that Mother Nature gave them, they capsize when confronted with the slightest ripple. But no more!

Due to the wonders of 3D printing, and painstaking design work by [Jan] from the Rubber Ducky Research Center, now you can print your own rubber ducky feet. We have the technology! Your ducks are no longer constrained to a life in the tub, but can roam free as nature intended. The video (embedded below) will certainly tug at your heartstrings.

OK, it’s a quick print and it made my son laugh.

The base and legs probably don’t fit your duck as-is, but it’s a simple matter to scale them up or down while slicing. (Picture me with calipers on the underside of a rubber ducky.) The legs were a tight press-fit into the body, so you might consider slimming them down a tiny bit when doing the scaling, but this probably depends on your printer tolerances.

It looks snazzy in gold-fleck PETG, and would probably work equally well for some more elaborate rubber duckies as well.

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