Medical Hacks

658 Articles

Synthesizing Daraprim To Beat Price Gougers

September 11, 2017 by 35 Comments

Drugs are used the world over to treat disease. However, from time to time, the vagaries of market economics, or unscrupulous action, can radically increase the price of otherwise cheap pharmaceuticals far beyond the reach of the average person. This was the case with Pyrimethamine (sold as Daraprim), which is used to treat toxoplasmosis and malaria, among other users. With the price skyrocketing from $13 to $750 a tablet in the US in 2015, [NurdRage] decided to synthesize the drug on their own. (If you missed the background hubbub, search for “Martin Shkreli”.)

The video linked covers the final synthesis, though [NurdRage] has previously covered the synthesis of the required precursor chemicals. Budding chemists may grow excited, but there are significant hurdles to attempting this synthesis yourself. Chemicals involved are carcinogenic, toxic, acidic, or otherwise dangerous, and a fume hood is a necessity if working inside. Outside of this, there are immense risks in homebrewing pharmaceuticals. Performing the synthesis of an important drug is one thing, but to do so at a medical-grade level where the products are safe for human consumption is on an entirely different level.

Overall, [NurdRage] has put out a series of videos that have strong educational value, showing us what really goes into the production of a common pharmaceutical compound. There’s also something to be said about taking the production of life-saving medicines into one’s own hands in the face of prohibitive treatment costs. In a similar vein, perhaps you’ve considered producing your own insulin in an emergency?

[Thanks to jwrm22 for the tip]

Magnet Implants, Your Cyborg Primer

September 8, 2017 by 79 Comments

What would you do to gain a sixth sense? Some of us would submit to a minor surgical procedure where a magnet is implanted under the skin. While this isn’t the first time magnet implants have been mentioned here on Hackaday, [The Thought Emporium] did a phenomenal job of gathering the scattered data from blogs, forum posts, and personal experimentation into a short video which can be seen after the break.

As [The Thought Emporium] explains in more eloquent detail, a magnet under the skin allows the implantee to gain a permanent sense of strong magnetic fields. Implantation in a fingertip is most common because nerve density is high and probing is possible. Ear implants are the next most useful because oscillating magnetic fields can be translated to sound.

For some, this is merely a parlor trick. Lifting paper clips and messing with a compass are great fun. Can magnet implants be more than whimsical baubles?

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Hackaday Prize Entry: Remote Control By Head Gestures

September 3, 2017 by 8 Comments

Some people may think they’re having a bad day when they can’t find the TV remote. Yet there are some people who can’t even hold a remote, let alone root around in the couch cushions where the remote inevitably winds up. This entry in the Assistive Technologies phase of the 2017 Hackaday Prize seeks to help such folks, with a universal remote triggered by head gestures.

Mobility impairments can range from fine motor control issues to quadriplegia, and people who suffer from them are often cut off from technology by the inability to operate devices. [Cassio Batista] concentrated on controlling a TV for his project, but it’s easy to see how his method could interface with other IR remotes to achieve control over everything from alarm systems to windows and drapes. His open-source project uses a web cam to watch a user’s head gestures, and OpenCV running on a CHIP SBC looks for motion in the pitch, yaw, and roll axes to control volume, channel, and power. An Arduino takes care the IR commands to the TV. The prototype works well in the video below; with the power of OpenCV we can imagine mouth gestures and even eye blinks adding to the controller’s repertoire.

The Assistive Tech phase wraps up tomorrow, so be sure to get your entries in. You’ll have some stiff competition, like this robotic exoskeleton. But don’t let that discourage you.

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Hackaday Prize Entry: Fighting Dehydration One Sip At A Time

September 2, 2017 by 22 Comments

Humans don’t survive long without water, and most people walk around in a chronic state of mild dehydration even if they have access to plenty of drinking water. It’s hard to stay properly hydrated, and harder still to keep track of your intake, which is the idea behind this water-intake monitoring IoT drinking straw.

Dehydration is a particularly acute problem in the elderly, since the sense of thirst tends to diminish with age. [jflaschberger]’s Hackaday Prize entry seeks to automate the tedious and error-prone job of recording fluid intake, something that caregivers generally have to take care of by eyeballing that half-empty glass and guessing. The HydrObserve uses a tiny turbine flowmeter that can mount to a drinking straw or water bottle cap. A Hall sensor in the turbine sends flow data to a Cypress BLE SoC module, which totalizes the volume sipped and records a patient identifier. A caregiver can then scan the data from the HydrObserve at the end of the day for charting and to find out if anyone is behind on their fluids.

There are problems to solve, not least being the turbine, which doesn’t appear to be food safe. But that’s a small matter that shouldn’t stand in the way of an idea as good as this one. We’ve seen a lot of good entries in the Assistive Technology phase of the 2017 Hackaday Prize, like a walker that works on stairs or sonic glasses for the blind. There are only a couple of days left in this phase — got any bright ideas?

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Detecting Dire Diseases – With A Selfie?

August 30, 2017 by 27 Comments

They say the eyes are the windows to the soul. But with a new smartphone app, the eyes may be a diagnostic window into the body that might be used to prevent a horrible disease — pancreatic cancer. A research team at the University of Washington led by [Alex Mariakakis] recently described what they call “BiliScreen,” a smartphone app to detect pancreatic disease by imaging a patient’s eyes.

Pancreatic cancer is particularly deadly because it remains asymptomatic until it’s too late. One early symptom is jaundice, a yellow-green discoloration of the skin and the whites of the eyes as the blood pigment bilirubin accumulates in the body. By the time enough bilirubin accumulates to be visible to the naked eye, things have generally progressed to the inoperable stage. BiliScreen captures images of the eyes and uses image analysis techniques to detect jaundice long before anyone would notice. To control lighting conditions, a 3D-printed mask similar to Google’s Cardboard can be used; there’s also a pair of glasses that look like something from [Sir Elton John]’s collection that can be used to correct for ambient lighting. Results look promising so far, with BiliScreen correctly identifying elevated bilirubin levels 90% of the time, as compared to later blood tests. Their research paper has all the details (PDF link).

Tools like BiliScreen could really make a difference in the early diagnosis and prevention of diseases. For an even less intrusive way to intervene in disease processes early, we might also be able to use WiFi to passively detect Parkinson’s.

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Hackaday Prize Entry: CPAP Humidifier Monitor Alarm

August 25, 2017 by 31 Comments

CPAP (Continuous Positive Airway Pressure) machines can be life-changing for people with sleep apnea. [Scott Clandinin] benefits from his CPAP machine and devised a way to improve his quality of life even further with a non-destructive modification to monitor his machine’s humidifier.

With a CPAP machine, all air the wearer breathes is air that has gone through the machine. [Scott]’s CPAP machine has a small water reservoir which is heated to humidify the air before it goes to the wearer. However, depending on conditions the water reservoir may run dry during use, leading to the user waking up dried out and uncomfortable.

To solve this in a non-invasive way that required no modifications to the machine itself, [Scott] created a two-part device. The first part is a platform upon which the CPAP machine rests. A load cell interfaced to an HX711 Load Cell Amplifier allows an Arduino Nano to measure the mass of the CPAP machine plus the integrated water reservoir. By taking regular measurements, the Arduino can detect when the reservoir is about to run dry and sound an alarm. Getting one’s sleep interrupted by an alarm isn’t a pleasant way to wake up, but it’s much more pleasant than waking up dried out and uncomfortable from breathing hot, dry air for a while.

The second part of the device is a simple button interfaced to a hanger for the mask itself. While the mask is hung up, the system is idle. When the mask is removed from the hook, the system takes measurements and goes to work. This makes activation hassle-free, not to mention also avoids spurious alarms while the user removes and fills the water reservoir.

Non-invasive modifications to medical or other health-related devices is common, and a perfect example of nondestructive interfacing is the Eyedriveomatic which won the 2015 Hackaday Prize. Also, the HX711 Load Cell Amplifier has an Arduino library that was used in this bathroom scale refurb project.

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Condom And Catheter Team Up To Save New Mothers’ Lives

August 6, 2017 by 43 Comments

The title is sure to draw a snicker from some readers, but the purpose of this field-expedient treatment for postpartum hemorrhage is deadly serious, and a true medical hack that has the potential to save the lives of new mothers.

Postpartum hemorrhage is the leading cause of death during pregnancy, claiming about 86,000 women every year. While it can occur up to six weeks after giving birth, PPH is most serious immediately after delivery and can require aggressive treatment to prevent hypovolemic shock and eventual death. A fully equipped obstetrical suite will have access to an array of medications and devices to staunch the flow, including a uterine balloon tamponade (UBT) kit. But at $400 a kit, these devices are hard to come by in the developing world.

Not to be dissuaded, midwife [Anne Mulinge] from Nairobi, Kenya created a simple, cheap substitute using common items. A common urinary catheter is covered with an ordinary condom, the end of which is secured around the catheter with twine. Once inserted into the woman’s uterus, the condom is filled with saline solution through the catheter, expanding the condom and applying direct pressure to the bleeding uterine walls. The pressure allows the mother’s clotting mechanism to catch up with the decreased blood flow.

So far, [Anne] claims the device has saved three new mothers, and other midwives are being trained in the technique. Here’s hoping that more lives are saved with this simple hack, and perhaps with this more complex one designed to get blood to remote clinics as fast as possible.

Thanks to [LP Bing] for the tip.