The Use Of Ultrasound To Take On Cancerous Tumors

January 6, 2026 by 31 Comments

As areas of uncontrolled cell growth, cancerous growth form a major problem for a multi-celled organism like us humans. Thus before they can begin to affect our long-term prospects of a continued existence, eradicating these cells-gone-wrong is essential. Unfortunately, doing so without affecting healthy cells significantly is tough. Treatments such as chemotherapy are correspondingly rough on the body, while radiation therapy is a lot more directed. Perhaps one of the more fascinating treatments involves ultrasound, with the IEEE Spectrum magazine recently covering one company providing histotripsy equipment.

Diagram showing how HIFU can be used to destroy tissue in the body. An acoustic lens is used to focus sound to a small point in the body. (Credit: James Ross McLaughlan, Wikimedia)
Diagram showing how HIFU can be used to destroy tissue in the body. An acoustic lens is used to focus sound to a small point in the body. (Credit: James Ross McLaughlan, Wikimedia)

Ultrasound has found many applications in the medical field far beyond imaging, with therapeutic ultrasound by itself covering a variety of methods to perform actions within the body without breaking the skin. By using high-energy ultrasound, everything from kidney stones to fat cells and cancerous cells can be accurately targeted and destroyed. For liver tumors the application of so-called histotropsy has become quite common, allowing certain types of tumors to be ablated non-invasively after which the body can handle the clean-up.

Histotropsy is a form of high-intensify focused ultrasound (HIFU) that uses either continuous or pulsed waves to achieve the desired effect, with the HIFU transducer equipped with an acoustic lens to establish a focal point. In the case of histotripsy cavitation is induced at this focal point that ends up destroying the local tissue. Beyond liver tumors the expectation is that other tumors will soon be treated in a similar manner, which could be good news for especially solid tumors.

Along with new approaches like CAR T cell immunotherapy, the prospects for cancer becoming a very treatable set of diseases would seem to be brighter than ever.

How Advanced Autopilots Make Airplanes Safer When Humans Go AWOL

January 6, 2026 by 21 Comments

It’s a cliché in movies that whenever an airplane’s pilots are incapacitated, some distraught crew member queries the self-loading freight if any of them know how to fly a plane. For small airplanes we picture a hapless passenger taking over the controls so that a heroic traffic controller can talk them through the landing procedure and save the day.

Back in reality, there have been zero cases of large airliners being controlled by passengers in this fashion, while it has happened a few times in small craft, but with variable results. And in each of these cases, another person in the two- to six-seater aircraft was present to take over from the pilot, which may not always be the case.

To provide a more reliable backup, a range of automated systems have been proposed and implemented. Recently, the Garmin Emergency Autoland system got  its first real use: the Beechcraft B200 Super King Air landed safely with two conscious pilots on board, but they let the Autoland do it’s thing due to the “complexity” of the situation.

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Super Mario 64, Now With Microtransactions

January 6, 2026 by 13 Comments

Besides being a fun way to pass time, video gaming is a surprisingly affordable hobby per unit time. A console or budget PC might only cost a few hundred dollars, and modern games like Hollowknight: Silksong can provide 40-60 hours of experience for only around $20 USD. This value proposition wasn’t really there in the 80s, where arcade cabinets like Gauntlet might have cost an inflation-adjusted $8 per hour in quarters. This paradigm shift is great for gamers, but hasn’t been great for arcade owners. [PrintAndPanic] wanted to bring some of that old coin munching vibe into console gaming, and so added a credit system to Super Mario 64.

The project is a fork of a decompilation of Super Mario 64, which converts the original machine code into a human-friendly format so bugs can be fixed and other modern features added. With the code available, essentially anyone can add features into the game that weren’t there already. In this case, [PrintAndPanic] is using a Raspberry Pi connected to a coin slot, so when coins are put into the game like an old arcade machine, the Raspberry Pi can tell the modified version of Super Mario 64 to add credits. These credits allow the player to run and jump, and when the credits run out Mario becomes extremely limited and barely able to outrun even the slowest Bombombs and Goombas.

With some debugging out of the way and the custom game working, [PrintAndPanic] built a custom enclosure for the game and the coin slot to turn it into a more self-contained arcade-style machine. The modified code for this project is available on the project’s GitHub page for those who want to play a tedious version of a favorite video game that costs more money than it should.

There are plenty of other modifications for this classic as well, most of which involve improving the game instead of adding a modern microtransaction-based system.

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Powering On A 1985 Photophone CP220 Videoconference System

January 6, 2026 by 9 Comments

The concept of remote video calls has been worked on since Bell’s phone company began pitching upgrading from telegrams to real-time voice calls. It wasn’t until the era of digital video and real-time video compression that commercial solutions became feasible, with the 1985 Image Data Corporation Photophone CP220 being an early example. The CP220 is also exceedingly rare due to costing around $25,000 USD when adjusted to inflation. This makes the teardown and repair on the [SpaceTime Junction] channel a rather unique experience.

Perhaps the coolest part of the device is that the manual is integrated into the firmware, allowing you to browse through it on the monochrome CRT. Unfortunately after working fine for a while the device released the magic smoke, courtesy of the usual Rifa capacitors doing their thing. This is why a full teardown was necessary, resulting in the PSU being dug out and having said capacitors swapped.

After this deal the device powered on again, happily accepting a video input and saving screenshots to the floppy drive before it was replaced with a FDD emulator running FlashFloppy firmware. Unfortunately no video call was attempted, probably because of the missing camera and having to set up a suitable POTS landline for the built-in modem. Hopefully we’ll see that in an upcoming video to see what we common folk were missing out on back in the day.

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Messing With JPEGs In A Text Editor Is Fun And Glitchy

January 5, 2026 by 4 Comments

If you’re looking to edit an image, you might open it in Photoshop, GIMP, or even Paint Shop Pro if you’re stuck in 2005. But who needs it — [Patrick Gillespie] explores what can be done when editing a JPEG on a raw, textual level instead.

As the video explains, you generally can’t simply throw a JPEG into Notepad and start making changes all willy nilly. That’s because it’s very easy to wreck key pieces of the image format that are required to render it as an image. Particularly because Notepad likes to sanitize things like line endings which completely mess up the structure of the file. Instead, you’re best off using a binary editor that will only change specific bytes in the image when you tell it to. Do this, and you can glitch out an image in all kinds of fun digital ways… or ruin it completely. Your choice!

If you’d like to tinker around with this practice, [Patrick] has made a tool for just that purpose. Jump over to the website, load the image of your choice, and play with it to your heart’s content.

This practice is often referred to as “datamoshing,” which is a very cool word, or “databending,” which isn’t nearly as good. We’ve explored other file-format hacks before, too, like a single file that can be opened six different ways. Video after the break.

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Close-Up Look Reveals That Raindrops Are More Erosive Than Assumed

January 5, 2026 by 18 Comments

Whenever it rains, people generally don’t look too closely at what the drops do exactly when they hit a surface. We generally assume that stuff will get wet and depending on the slope of the surface it’ll run off downhill at some point, probably in a nice, neat flow. Of course, reality doesn’t work that way, as Swiss researchers recently found when they pointed high-speed cameras at simulated raindrops. Their findings were published recently in Applied Physical Sciences, which is sadly paywalled, but the summary article over at phys.org provides some details, including a video.

The researchers set up a 1.2 meter long dry silicate sand surface with a 30° slope on which the drops were released. In the top image you can see two stills of the result, with the full video showing the drops turning into either peanut- or doughnut-shaped forms that gathered significant amounts of sand grains. These grains mix with the water, allowing a single drop to erode significant amounts of material from a slope, more than was previously assumed in existing soil erosion models.

Beyond erosion, these findings also offer insights for similar dynamics in other fields, all thanks to a group of researchers who got curious during a rainy walk and decided to take a closer look.

A round, 3D-printed motor housing is shown, with one flattened side holding a fan mount. A circular plate is mounted above the face of the housing, and a cord runs around it and pulleys on the side of the housing.

Tying Up Loose Ends On A Rope-based Robot Actuator

January 5, 2026 by 9 Comments

One of the perennial challenges of building robots is minimizing the size and weight of drive systems while preserving power. One established way to do this, at least on robots with joints, is to fit each joint with a quasi-direct-drive motor integrating a brushless motor and gearbox in one device. [The 5439 Workshop] wanted to take this approach with his own robot project, but since commercial drives were beyond his budget, he designed his own powerful, printable actuator.

The motor reducing mechanism was the biggest challenge: most quasi-direct drives use a planetary gearbox, but this would have been difficult to 3D-print without either serious backlash or limited torque. A cycloidal drive was an option, but previous printable cycloidal drives seemed to have low efficiency, and they didn’t want to work with a strain-wave gearing. Instead, he decided to use a rope drive (this seems to be another name for a kind of Capstan drive), which doesn’t require particularly strong materials or high precision. These normally use a rope wound around two side-by-side drums, which are difficult to integrate into a compact actuator, but he solved the issue by putting the drums in-line with the motor, with two pairs of pulleys guiding the rope between them in a “C” shaped path.

The actual motor is a hand-wound stator inside a 3D-printed rotor with magnets epoxied into it. The printed rotor proved problematic when the attraction between the rotor and magnets caused it to flex and scrape against the housing, and it eventually had to be reinforced with some thin metal sheets. After fixing this, it reached five Newton-meters of torque at one amp and nine Newton-meters at five amps. The diminishing returns seem to be because the 3D-printed pulley wheels broke under higher torque, which should be easy to fix in the future.

This looks like a promising design, but if you don’t need the output shaft inline with the motors, it’s probably easier to build a simple Capstan drive, the mathematics of which we’ve covered before. Both makers we’ve previously seen build Capstan drives used them to make robot dogs, which says something for their speed and responsiveness.