Science and engineering usually create consistent results. Generally, when you figure out how to make something, you can repeat that at will to make more of something. But what if, one day, you ran the same process, and got different results? You double-checked, and triple-checked, and you kept ending up with a different end product instead?
Perhaps it wasn’t the process that changed, but the environment? Or physics itself? Enter the scary world of disappearing polymorphs.
To the uninitiated, it might seem like a gimmick to 3D print pharmaceuticals. After all, you take some kind of medicine, pour it in a mold, and you have a pill, right? But researchers and even some commercial companies are 3D printing drugs with unusual chemical or physical properties. For example, pills with braille identification on them or antibiotics with complex drug-release rates. The Universidade de Santiago de Compostela and the University College London can now 3D print pills without relying on a layer-by-layer approach. Instead, the machine produces the entire pill directly.
According to a recent report on the study, there are at least two things holding back printed pills. First, anything medical has to go through rigorous testing for approval in nearly any country. In addition, producing pills at typical 3D printing speeds is uneconomical. This new approach uses multiple beams of light to polymerize an entire tank of resin at once in as little as seven seconds.
With 3D printed drugs, it is possible to tailor release profiles for individual cases and make hybrid drugs such as a French drug that joins anticancer drugs with another drug to manage side effects. Is this a real thing for the future? Will doctors collect enough data to make it meaningful to tailor drugs to patients? Will regulators allow it? For hybrid medicine, is there really an advantage over just taking two pills? Only time will tell.
Sure, technology can help dispense pills. We know, too, that 3D printing can be useful for prostheses and medical devices. We aren’t so sure about pharmaceuticals, but in the meantime you can already order custom-printed vitamins.
When you’ve got a diabetic in your life, there are few moments in any day that are free from thoughts about insulin. Insulin is literally the first coherent thought I have every morning, when I check my daughter’s blood glucose level while she’s still asleep, and the last thought as I turn out the lights, making sure she has enough in her insulin pump to get through the night. And in between, with the constant need to calculate dosing, adjust levels, add corrections for an unexpected snack, or just looking in the fridge and counting up the number of backup vials we have on hand, insulin is a frequent if often unwanted intruder on my thoughts.
And now, as my daughter gets older and seeks like any teenager to become more independent, new thoughts about insulin have started to crop up. Insulin is expensive, and while we have excellent insurance, that can always change in a heartbeat. But even if it does, the insulin must flow — she has no choice in the matter. And so I thought it would be instructional to take a look at how insulin is made on a commercial scale, in the context of a growing movement of biohackers who are looking to build a more distributed system of insulin production. Their goal is to make insulin affordable, and with a vested interest, I want to know if they’ve got any chance of making that goal a reality.
Continue reading “Open-Source Insulin: Biohackers Aiming For Distributed Production”
Love it or loathe it, the pharmaceutical industry is really good at protecting its intellectual property. Drug companies pour billions into discovering new drugs and bringing them to market, and they do whatever it takes to make sure they have exclusive positions to profit from their innovations for as long a possible. Patent applications are meticulously crafted to keep the competition at bay for as long as possible, which is why it often takes ages for cheaper generic versions of blockbuster medications to hit the market, to the chagrin of patients, insurers, and policymakers alike.
Drug companies now appear poised to benefit from the artificial intelligence revolution to solidify their patent positions even further. New computational methods are being employed to not only plan the synthesis of new drugs, but to also find alternative pathways to the same end product that might present a patent loophole. AI just might change the face of drug development in the near future, and not necessarily for the better.
Continue reading “AI Patent Trolls Now On The Job For Drug Companies”
We’ve covered construction of novel music instruments on these pages, and we’ve covered many people tearing down scientific instruments. But today we’ve got something that managed to cross over from one world of “instrument” into another: a music instrument modified to measure a liquid’s density by listening to changes in its pitch.
This exploration started with a mbira, a mechanically simple music instrument. Its row of rigid metal tines was replaced with a single small diameter hollow metal tube. Filling the tube with different liquids would result in different sounds. Those sounds are captured by a cell phone and processed by an algorithm to calculate the difference in relative density of those liquids. Once the procedure was worked out, the concept was verified to work on a super simple instrument built out of everyday parts: a tube mounted on a piece of wood.
At this point we have something that would be a great science class demonstration, but the authors went a step further and described how this cheap sensor can be used to solve an actual problem: detecting counterfeit pharmaceuticals. Changing composition of a drug would also change its density, so a cheap way to compare densities between a questionable sample against a known good reference could be a valuable tool in parts of the world where chemistry labs are scarce.
For future development, this team invites the world to join them applying the same basic idea in other ways, making precise measurements for almost no cost. “Any physical, chemical, or biological phenomena that reproducibly alters the pitch-determining properties of a musical instrument could in principle be measured by the instrument.” We are the ideal demographic to devise new variations on this theme. Let us know what you come up with!
If you need to do quick tests before writing analysis software, audio frequency can be measured using the Google Science Journal app. We’ve seen several hacks turning a cell phone’s camera into instruments like a spectrometer or microscope, but hacks using a phone’s microphone is less common and ripe for exploration. And anyone who manages to make cool measurements while simultaneously making cool music will instantly become a serious contender in our Hackaday Prize music instrument challenge!
[via Science News]
Drugs are used the world over to treat disease. However, from time to time, the vagaries of market economics, or unscrupulous action, can radically increase the price of otherwise cheap pharmaceuticals far beyond the reach of the average person. This was the case with Pyrimethamine (sold as Daraprim), which is used to treat toxoplasmosis and malaria, among other users. With the price skyrocketing from $13 to $750 a tablet in the US in 2015, [NurdRage] decided to synthesize the drug on their own. (If you missed the background hubbub, search for “Martin Shkreli”.)
The video linked covers the final synthesis, though [NurdRage] has previously covered the synthesis of the required precursor chemicals. Budding chemists may grow excited, but there are significant hurdles to attempting this synthesis yourself. Chemicals involved are carcinogenic, toxic, acidic, or otherwise dangerous, and a fume hood is a necessity if working inside. Outside of this, there are immense risks in homebrewing pharmaceuticals. Performing the synthesis of an important drug is one thing, but to do so at a medical-grade level where the products are safe for human consumption is on an entirely different level.
Overall, [NurdRage] has put out a series of videos that have strong educational value, showing us what really goes into the production of a common pharmaceutical compound. There’s also something to be said about taking the production of life-saving medicines into one’s own hands in the face of prohibitive treatment costs. In a similar vein, perhaps you’ve considered producing your own insulin in an emergency?
[Thanks to jwrm22 for the tip]
These water droplets are not falling; they’re actually stuck in place. What we’re seeing is the effects of an acoustic levitator. The device was initially developed by NASA to simulate microgravity. Now it’s being used by the pharmaceutical industry do develop better drugs.
The two parts of the apparatus seen in the image above are both speakers. They put out a sound at about 22 kHz, which is beyond the human range of hearing. When precisely aligned they interfere with each other and create a standing wave. The droplets are trapped in the nodes of that wave.
So are these guys just playing around with the fancy lab equipment? Nope. The levitation is being used to evaporate water from a drug without the substance touching the sides of a container. This prevents the formation of crystals in the solution. But we like it for the novelty and would love to see someone put one of these together in their home workshop.
Don’t miss the mystical demo in the clip after the break.
