Love it or loathe it, the pharmaceutical industry is really good at protecting its intellectual property. Drug companies pour billions into discovering new drugs and bringing them to market, and they do whatever it takes to make sure they have exclusive positions to profit from their innovations for as long a possible. Patent applications are meticulously crafted to keep the competition at bay for as long as possible, which is why it often takes ages for cheaper generic versions of blockbuster medications to hit the market, to the chagrin of patients, insurers, and policymakers alike.
Drug companies now appear poised to benefit from the artificial intelligence revolution to solidify their patent positions even further. New computational methods are being employed to not only plan the synthesis of new drugs, but to also find alternative pathways to the same end product that might present a patent loophole. AI just might change the face of drug development in the near future, and not necessarily for the better.
Continue reading “AI Patent Trolls Now on the Job for Drug Companies”
Our bodies are not like LEGO blocks or computers because we cannot swap out our parts in the living room while watching television. Organ transplants and cosmetic surgery are currently our options for upgrades, repairs, and augments, but post-transplant therapy can be a lifelong commitment because of rejection. Elective surgery costs more than a NIB Millenium Falcon LEGO set. Laboratories have been improving the processes and associated treatments for decades but experimental labs and even home laboratories are getting in on the action as some creative minds take the stage. These folks aren’t performing surgeries, but they are expanding what is possible to for people to do and learn without a medical license.
One promising gateway to human building blocks is the decellularization and recellularization of organic material. Commercial scaffolds exist but they are expensive, so the average tinkerer isn’t going to be buying a few to play with over a holiday weekend.
Let’s explore what all this means. When something is decellularized, it means that the cells are removed, but the structure holding the cells in place remains. Recellularizing is the process where new cells are grown in that area. Decellularizing is like stripping a Hilton hotel down to the girders. The remaining structures are the ECM or the Extra Cellular Matrix, usually referred to as scaffolding. The structure has a shape but no functionality, like a stripped hotel. The scaffolding can be repopulated with new cells in the same way that our gutted hotel can be rebuilt as a factory, office building, or a hospital.
Continue reading “Decellularization: Apples to Earlobes”
All “methane generator” jokes aside, This one actually serves a useful purpose. Although not an engine hack per se, methane can be used to run an engine. As the traditional method of powering an internal combustion engine, gasoline, gets more and more expensive, alternatives will have to be found. If you happen to live on a farm, or have access to a source of organic waste, this method could serve as a viable one.
One would need quite a bit of waste, as each kilogram yields around 400 liters of methane gas. This amount is enough to run a gas light for around 4 hours. Any sort of useful engine would require quite a bit more than this (chicken farm possibly?).
A process for converting waste to fuel is illustrated in the video after the break. Extreme caution should be used if attempting to do something like this. There is a danger of not only flammable gas leaking and catching on fire or exploding, but the organic material can be quite toxic as well. Continue reading “Engine Hacks – A DIY Methane Generator”