The Most Brilliant Use of Crowdfunding Yet: Medical Research

Since the rise of Kickstarter and Indiegogo, the world has been blessed with $100 resin-based 3D printers, Video game consoles built on Android, quadcopters that follow you around, and thousands of other projects that either haven’t lived up to expectations or simply disappeared into the ether. The idea of crowdfunding is a very powerful one: it’s the ability for thousands of people to chip in a few bucks for something they think is valuable. It’s a direct democracy for scientific funding. It’s the potential for people to pool their money, give it to someone capable, and create something really great. The reality of crowdfunding isn’t producing the best humanity has to offer. Right now, the top five crowdfunding campaigns ever are two video games, a beer cooler, a wristwatch with an e-ink screen, and something to do with Bitcoin. You will never go broke underestimating people.

[Dr. Todd Rider] wants to change this. He might have developed a way to cure nearly all viral diseases in humans, but he can’t find the funding for the research to back up his claims. He’s turned to IndieGoGo with an audacious plan: get normal people, and not NIH grants, to pay for the research.

The research [Dr. Rider] has developed is called the DRACO, the Double-stranded RNA Activated Caspase Oligomerizer. It works by relying on the singular difference between healthy cells and infected cells. Infected cells contain long chains viral double-stranded RNA. The DRACOs attach themselves to these long strands of RNA and cause those cells to commit suicide. The research behind the DRACO was published in 2011, and since then [Dr. Rider] has already received funding from more traditional sources, but right now the project is stuck in the ‘funding valley of death’. It’s easy to get funding for early research, but to get the millions of dollars for clinical trials it takes real results – showing efficacy, and proving to pharmaceutical companies or VCs that the drug will make money.

So far, results are promising, but far from the cure for HIV and the common cold the DRACO promises to be. [Dr. Rider] has performed a few tests on cell cultures and mice, and the DRACOs have been effective in combating everything from the common cold, to the flu to dengue hemorrhagic fever.

The IndieGoGo campaign is flexible funding, meaning all the money raised will go towards research even if the funding goal is not met. Right now, just over $50,000 has been raised of a $100,000 goal. That $100k goal is just the first step; [Dr. Rider] thinks he’ll need about $2 Million to test DRACOs against more viruses and hopefully show enough progress to get additional traditional funding. That $2 Million is a little less than what Solar Roadways raised, meaning no matter what [Dr. Rider] will make one important medical discovery: people are very, very, very dumb.

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Measuring Capacitance Against Voltage

Ceramic capacitors are pretty much the pixie dust of the electronics world. If you sprinkle enough of them on a circuit, everything will work. These ceramic capacitors aren’t the newest and latest technology, though: you can find them in radios from the 1930s, and they have one annoying property: their capacitance changes in relation to voltage.

This is a problem if you’re relying on ceramic caps in an RC filter or a power supply. What you need is a device that will graph capacitance against voltage, and [limpkin] is here to show you how to do it.

Of course capacitance is usually measured by timing how long it takes to charge and discharge a cap through an RC oscillator. This requires at least one known value – in this case a 0.1% resistor – by measuring the time it takes for this circuit to oscillate, an unknown capacitance can be calculated.

That’s all well and good, but how do you measure capacitance against a bias voltage? EDN comes to save the day with a simple circuit built around an op-amp. This op-amp is just a comparator, with the rest of the circuit providing a voltage directly proportional to the percentage of charge in the capacitor.

This little project is something [limpkin] has turned into a Kickstarter, and it’s something we’ve seen before. That said, measuring capacitance against a voltage isn’t something any ‘ol meter can do, and we’re glad [limpkin] could put together an easy to use tool that measures this phenomenon.

Windows 10 On A Tiny Board

Over the past few months, a number of companies and designers have started picking up the newest Intel SoCs. Intel has to kill ARM somehow, right? The latest of these single board x86 computers is the Lattepanda. It’s a tiny board that can run everything a 5-year-old desktop computer can run, including a full version of Windows 10.

This isn’t the first time we’ve seen a tiny x86 board in recent months. Last October, an x86 board that takes design cues from the Raspberry Pi 2 hit Kickstarter. These are proper PCs, with the ability to run Windows 10, Linux, and just about every other environment under the sun.

The specs for the Lattepanda include a quad-core Cherry Trail running at 1.8GHz. the RAM is either 2GB or 4GB depending on configuration, and 32GB of eMMC Flash. Peripherals include USB 3.0, Ethernet, WiFi, Bluetooth, and integrated graphics supporting either HDMI or a DSI connector.

But of course a computer is just a computer, and you can’t sell a machine that only runs Skype to the ‘maker’ market. The Lattepanda also includes an ATMega32u4 as a coprocessor, giving this board ‘Arduino functionality’. In my day we walked uphill both ways to get a parallel port, but I digress.

While these tiny x86 boards might not be available in a year’s time, and the companies behind them may fall off the face of the planet, the introduction of these devices portends a great war over the horizon. Intel wants the low-power SoC market, a space until now reserved entirely for ARM-based devices.

Tiny Arcade, Based on Arduino

Who can resist video games when they’re packed up in tiny, tiny little arcade machines? [Ken]’s hoping that you cannot, because he’s making a cute, miniature Arduino-based arcade game platform on Kickstarter. (Obligatory Kickstarter promo video below the break.)

The arcades are based on [Ken]’s TinyCircuits Arduino platform — a surprisingly broad range of Arduino modules that click together using small snap connectors in place of pin headers. The system is cool enough in its own right, and it appears to be entirely open source. Housing these bits in a cute arcade box and providing working game code to go along with it invites hacking.

There’s something about tiny video cabinets. We’ve seen people cram a Game Boy Advance into a tiny arcade cabinet and re-house commercial video game keyfobs into arcade boxes. Of course, there’s the Rasbperry Pi. From [Sprite_TM]’s cute little MAME cabinet to this exquisite build with commercially 3D-printed parts, it’s a tremendously appealing project.

But now, if you’re too lazy to build your own from scratch, and you’ve got $60 burning a hole in your pocket, you can get your own tiny arcade — and tiny Arduino kit — for mere money. A lot of people have already gone that route as they passed the $25k funding goal early yesterday. Congrats [Ken]!

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Measuring Capacitors Over Their Working Voltage

Ceramic capacitors are small, they don’t leak, they’re convenient, but they are downright strange. Certain types of caps will lose their capacitance depending on the voltage they’re operating at. If you’re using ceramic caps for filters, DC to DC power supplies, bypass caps, or anything where you need an exact capacitance in a circuit, this can be a problem.

[Mathieu] has come up with a tool that’s able to measure the capacitance of a cap over its entire working range. He’s calling it the OpenCVMeter, and although the name might be slightly confusing, the functionality is not. This little box will measure the capacitance of a part over a voltage range from 1.3 to 15.5V.

By attaching the SMD tweezers or test clips to a capacitor, the OpenCVMeter ramps up the voltage and measures the capacitance of the part through the test cycle. This data is then dumped to a Chrome app – a surprisingly popular platform for test equipment apps – and a determination of the cap’s ability will to work in a circuit is displayed on the screen

If you’ve ever tooled around with antique electronic equipment, you’ll know the first thing to go bad in any piece of equipment are caps. Either caps had extremely loose manufacturing tolerances back in the day or the values really were that critical, but a dodgy cap can bring down everything from tube amps to computers. It’s a very neat tool, and something that doesn’t really exist in a single dedicated device.

Physical Security for Desktop Computers

There’s a truism in the security circles that says physical security is security. It doesn’t matter how many bits you’ve encrypted your password with, which elliptic curve you’ve used in your algorithm, or if you use a fingerprint, retina scan, or face print for a second factor of authentication. If someone has physical access to a device, all these protections are just road bumps in the way of getting your data. Physical access to a machine means all that data is out in the open, and until now there’s nothing you could do to stop it.

This week at Black Hat Europe, Design-Shift introduced ORWL, a computer that provides the physical security to all the data sitting on your computer.

The first line of protection for the data stuffed into the ORWL is unique key fob radio. This electronic key fob is simply a means of authentication for the ORWL – without it, ORWL simply stays in its sleep mode. If the user walks away from the computer, the USB ports are shut down, and the HDMI output is disabled. While this isn’t a revolutionary feature – something like this can be installed on any computer – that’s not the biggest trick ORWL has up its sleeve.

ORWL2The big draw to the ORWL is a ‘honeycomb mesh’ that completely covers every square inch of circuit board. This honeycomb mesh is simply a bit of plastic that screws on to the ORWL PCB and connects dozens of electronic traces embedded in this board to a secure microcontroller. If these traces are broken – either through taking the honeycomb shell off or by breaking it wide open, the digital keys that unlock the computer are erased.

The ORWL specs are what you would expect from a bare-bones desktop computer: Intel Skylake mobile processors, Intel graphics, a choice of 4 or 8GB of RAM, 64 to 512GB SSD. WiFi, two USB C ports, and an HDMI port provide all the connections to the outside world.

While this isn’t a computer for everyone, and it may not even a very large deployment, it is an interesting challenge. Physical security rules over all, and it would be very interesting to see what sort of attack can be performed on the ORWL to extract all the data hidden away behind an electronic mesh. Short of breaking the digital key hidden on a key fob, the best attack might just be desoldering the chips for the SSD and transplanting them into a platform more amenable to reading them.

In any event, ORWL is an interesting device if only for being one of the few desktop computers to tackle the problem of physical security. As with any computer, if you have physical access to a device, you have access to all the data on the device; we just don’t know how to get the data off one of these tiny computers.

Video below.

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Compressorhead: Best Robot Band Ever?

We’ve written about Compressorhead before but we’re writing about them again. Why? Because Compressorhead is the most amazing robot band you’ve ever seen, and because they’ve just opened up a Kickstarter to fund building a lead singer robot and recording an album.

And because they’ve released a bunch of new videos, one of which you’ll find below the break.

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