Patching Up Failing Hearts With Engineered Muscle Tissue

January 30, 2025 by Maya Posch 3 Comments

As the most important muscle in our body, any serious issues with our heart are considered critical and reason for replacement with a donor heart. Unfortunately donor hearts are rather rare, making alternatives absolutely necessary, or at the very least a way to coax the old heart along for longer. A new method here seems to be literally patching up a patient’s heart with healthy heart tissue, per the first human study results by [Ahmad-Fawad Jebran] et al. as published in Nature (as well as a partially paywalled accompanying article).

Currently, simple artificial hearts are a popular bridging method, which provide a patient with effectively a supporting pump. This new method is more refined, in that it uses induced pluripotent stem cells (iPS) from an existing hiPSC cell line (TC1133) which are then coaxed into forming cardiomyocytes and stromal cells, effectively engineered heart muscle (EHM). After first testing this procedure on rhesus macaque monkeys, a human trial was started involving a 46-year old woman with heart failure after a heart attack a few years prior.

During an operation in 2021, 10 patches of EHMs containing about 400 million cells each were grafted onto the failing heart. When this patient received a donor heart three months later, the removed old heart was examined and the newly grafted sections found to be healthy, including the development of blood vessels.

Although currently purely intended to be a way to keep people alive until they can get a donor heart, this research opens the tantalizing possibility of repairing a patient’s heart using their own cells, which would be significantly easier than growing (or bioprinting) an entire heart from scratch, while providing the benefit of such tissue patches grown from one’s own iPS cells not evoking an immune response and thus mitigating the need for life-long immune system suppressant drugs.

Featured image: Explanted heart obtained 3 months after EHM implantation, showing the healthy grafts. (Credit: Jebran et al., 2025, Nature)

Electrospinning Artificial Heart Valves

March 29, 2024 by Dan Maloney 10 Comments

When you think about additive manufacturing, thoughts naturally turn to that hot-glue squirting CNC machine sitting on your bench and squeezing whatever plastic doodad you need. But 3D printing isn’t the only way to build polymer structures, as [Riley] shows us with this fascinating attempt to create electrospun heart valves.

Now, you may never have heard of electrospinning, but we’ll venture a guess that as soon as you see what it entails, you’ll have a “Why didn’t I think of that?” moment. As [Riley] explains, electrospinning uses an electric field to build structures from fine threads of liquid polymer solution — he uses polycaprolactone (PCL), a biodegradable polyester we’ve seen used in other medical applications, which he dissolves in acetone. He loads it into a syringe, attaches the positive terminal of a high-voltage power supply to the hypodermic needle, and the negative terminal to a sheet of aluminum foil. The charge turns the PCL droplets into fine threads that accumulate on the foil; once the solvent flashes off, what’s left is a gossamer layer of non-woven plastic fabric.

To explore the uses of this material, [Riley] chose to make an artificial heart valve. This required a 3D-printed framework with three prongs, painted with conductive paint. He tried a few variations on the design before settling on a two-piece armature affixed to a rotating shaft. The PCL accumulates on the form, creating a one-piece structure that can be gingerly slipped off thanks to a little silicon grease used as a release agent.

The results are pretty impressive. The structure bears a strong resemblance to an artificial tricuspid heart valve, with three delicate leaves suspended between the upright prongs. It’s just a proof of concept, of course, but it’s a great demonstration of the potential of electrospinning, as well as an eye-opening look at what else additive manufacturing has to offer.

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Permanent Artificial Hearts: Long-Sought Replacements May Not Be Far Away

August 9, 2021 by Dan Maloney 44 Comments

The number of artificial prosthetic replacement parts available for the human body is really quite impressive. From prosthetic eyes to artificial hips and knees, there are very few parts of the human body that can’t be swapped out with something that works at least as well as the original, especially given that the OEM part was probably in pretty tough shape in the first place.

But the heart has always been a weak spot in humans, in part because of the fact that it never gets to rest, and in part because all things considered, we modern humans don’t take really good care of it. And when the heart breaks down past the point where medicine or surgery can help, we’re left with far fewer alternatives than someone with a bum knee would face. The fact is that the best we can currently hope for is a mechanical heart that lets a patient live long enough to find a donor heart. But even then, tragedy must necessarily attend, and someone young and healthy must die so that someone else may live.

A permanent implantable artificial heart has long been a goal of medicine, and if recent developments in materials science and electrical engineering have anything to say about it, such a device may soon become a reality. Heart replacements may someday be as simple as hip replacements, but getting to that point requires understanding the history of mechanical hearts, and why it’s not just as simple as building a pump.

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Swine Of The Times: Pig-to-Human Organ Transplants On Track For 2021

January 28, 2021 by Kristina Panos 73 Comments

Every day in the US, seventeen people die because they couldn’t get a organ transplant in time. An American biotech company called United Therapeutics is looking to pick up the lifesaving slack by producing a line of genetically-modified pigs for the purpose of harvesting their organs, among other therapeutic uses. United Therapeutics’ pig-farming subsidiary Revivicor is a spin-off of PPL Therapeutics, the company that gave us Dolly the cloned sheep back in 1996. They intend to start transplanting pig organs into humans as early as this year.

Baby Fae after transplant surgery. Image by Duane Miller-AP via Time Magazine

Although it sounds like science fiction, the idea of transplanting animal cells, organs, and tissue into humans has been around for over a hundred years. The main problem with xenotransplantation is that it usually triggers severe immune system reactions in the recipient’s body. In one of the more noteworthy cases, a baby girl received a baboon heart in 1984, but died a few weeks later because her body rejected the organ.

The leading cause of xenotransplant rejection is a sugar called alpha-gal. This sugar appears on the cell surfaces of all non-primate mammals. Alpha-gal is problematic for other reasons, too: a condition called alpha-gal syndrome usually begins when a Lone Star tick bites a person and transmits alpha-gal cells from the blood of animals they have bitten. From that point on, the person will experience an allergic reaction when eating red meat such as beef, pork, and lamb.

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Be Still, My Animatronic Heart

January 19, 2020 by Dan Maloney 10 Comments

Fair warning for the squeamish: some versions of [Will Cogley]’s animatronic heart are realistic enough that you might not want to watch the video below. That’d be a shame though, because he really put a lot of effort into the build, and the results have a lot to teach about mimicking the movements of living things.

As for why one would need an animatronic heart, we’re not sure. [Will] mentions no specific use case for it, although we can think of a few. With the Day of Compulsory Romance fast approaching, the fabric-wrapped version would make a great gift for the one who stole your heart, while the silicone-enrobed one could be used as a movie prop or an awesome prank. Whatever the reason, [Will]’s build is a case study in incremental development. He started with a design using a single continuous-rotation servo, which powered four 3D-printed paddles from a common crank. The four paddles somewhat mimicked the movements of the four chambers of the heart, but the effect wasn’t quite convincing. The next design used two servos and complex parallelogram linkages to expand each side of the heart in turn. It was closer, but still not quite right.

After carefully watching footage of a beating heart, [Will] decided that his mechanism needed to imitate the rapid systolic contraction and slow diastolic expansion characteristic of a real heart. To achieve this, his final design has three servos plus an Arduino for motion control. Slipped into a detailed silicone jacket, the look is very realistic. Check out the video below if you dare.

We’ve seen plenty of animatronic body parts before, from eyes to hands to entire faces. This might be the first time we’ve seen an animatronic version of an internal organ, though.

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WiFi Makes The Heart Glow Fonder

March 2, 2019 by Lewin Day 2 Comments

It’s more than a little too late for Valentine’s Day this year, but if you start now, you’re sure to be looking good next February. Print something that truly conveys how you feel, through the magic of wireless communication and RGB LEDs (Youtube, French).

Yes, [Heliox] has built a Valentine’s day project, and the presentation is top notch as always. A heart is 3D printed in white filament, with two chambers separated by a thick wall. Each chamber features five NeoPixel LEDs, controlled by an ESP8266 in the base. The color of each chamber can be controlled through the Blynk smartphone app, allowing you to choose the exact colors that best represent your relationship.

The 3D printed heart does a good job of diffusing the LEDs, with the device showing a rich and consistent glow without any unattractive hotspots. It’s a fun holiday build, and if you’re quick, you might just have time to print one yourself if you start right away.

[Heliox] has good form when it comes to LED projects – her infinity cube is particularly impressive. Video after the break.

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Love Inspires CD Player Hack

February 20, 2019 by Lewin Day 10 Comments

The heart is an impressive piece of hardware. It’s a rare pump that runs continuously for over 80 years in some cases. It’s also, for some reason or other, become a common human symbol of love and affection. In this vein, [Deepak Khatri] has built a beating electronic heart out of basic, readily available components.

The heart of the build (pun intended) is a lens assembly salvaged from a CD player, which uses a coil and permanent magnet to move the lens in order to read across a disc. In this case, the coil is instead fed pulses from an astable multivibrator circuit built with a hacker favourite, the 555 timer IC. It’s all assembled on a breadboard, which is a great way to build such projects that rely on experimentation through the swapping of component values.

The end result is rather satisfying. [Deepak] has also experimented with an Arduino driven version with a slightly different rhythm.

We haven’t seen too many projects using optical drive lens assemblies, but we’re sure there must be other applications. If you end up using one to agitate biological samples or build an awesome laser projector, be sure to hit up the tips line. Video after the break.

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