Of the body’s organs, the lungs are among the trickiest to take a biopsy and treat cancer in, both due to how important they are, as well as due to their inaccessibility. The total respiratory surface within the average human lungs is about 50 to 75 square meters. Maneuvering any kind of instrument down the endless passages to reach a suspicious area, or a cancerous region to treat is nearly impossible. This has so far left much of the lungs inaccessible.

The standard of care for lung cancer is generally surgical: remove parts of the lung tissue. However, a proposed new method using magnetic tentacles may soon provide a more gentle approach, as described in Nature Engineering Communications by Giovanni Pittiglio and colleagues (press release).

The tentacles are made out of a silicone substrate with embedded magnets that allow for it to be steered using external magnetic sources. With an embedded laser fiber, the head of the tentacle can be guided to the target area, and the cancerous tissue sublimated using an external laser source. In experiments on cadavers with this system, the researchers found that they could enter 37% deeper into the lungs than with standard equipment. The procedure was also completed with less tissue displacement.

Considering the high fatality rate of lung cancers, the researchers hope that this approach could soon be turned into a viable therapy, as well as for other medical conditions where a gentle tentacle slithering into the patient’s body could effect treatments previously considered to be impossible.

Heading image: Close-up of a magnetic tentacle robot next to a phantom bronchiole (Credit: University of Leeds)