Fixing A Fatal Genetic Defect In Babies With A Bit Of Genetic Modification

May 27, 2025 by 30 Comments

Genetic defects are exceedingly common, which is not surprising considering just how many cells make up our bodies, including our reproductive cells. While most of these defects have no or only minor effects, some range from serious to fatal. One of these defects is in the CPS1 gene, with those affected facing a shortened lifespan along with intensive treatments and a liver transplant as the only real solution. This may now be changing, after the first successful genetic treatment of an infant with CPS1 deficiency.

Carbamoyl phosphate synthetase I (CPS1) is an enzyme that is crucial for breaking down the ammonia that is formed when proteins are broken down. If the body doesn’t produce enough of this enzyme in the liver, ammonia will accumulate in the blood, eventually reaching levels where it will affect primarily the nervous system. As an autosomal recessive metabolic disorder it requires both parents to be carriers, with the severity depending on the exact mutation.

In the case of the affected infant, KJ Muldoon, the CPS1 deficiency was severe with only a low-protein diet and ammonia-lowering (nitrogen scavenging) medication keeping the child alive while a search for a donor liver had begun. It is in this context that in a few months time a CRISPR-Cas9 therapy was developed that so far appears to fixing the faulty genes in the liver cells.

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Reconditioning A Vintage CRT Tube

May 27, 2025 by 28 Comments

Plenty of readers will be familiar with CRT televisions, not least because many of us use them with retrocomputers and consoles. But perhaps fewer will have worked with CRTs themselves as components, and of those, fewer still will be familiar with the earlier generation of tubes. In the first few decades of color TV the tubes were so-called delta gun because their three electron guns were arranged in a triangular form. [Colorvac] has put up a video in which they demonstrate the reconditioning of one of these tubes from a late-1960s Nordmende TV.

The tube in question isn’t one of the earlier “roundies” you would find on an American color TV from the ’50s or early ’60s, instead it’s one of the first generation of rectangular (ish) screens. It’s got an under-performing blue gun, so they’re replacing the electron gun assembly. Cutting the neck of the tube, bonding a new neck extension, and sealing in a new gun assembly is not for the faint-hearted, and it’s clear they have both the specialist machinery and the experience required for the job. Finally we see the reconditioned tube put back into the chassis, and are treated to a demonstration of converging the three beams.

For those of us who cut our teeth on these devices, it’s fascinating.

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Hands-On: EufyMake E1 UV Printer

May 27, 2025 by 50 Comments

The modern hacker and maker has a truly incredible arsenal of tools at their disposal. High-tech tools like 3D printers, laser cutters, and CNC routers have all become commonplace, and combined with old standbys like the drill press and mini lathe, it sometimes seems like we’ve finally peaked in terms of what the individual is realistically capable of producing in their own home. But occasionally a new tool comes along, and it makes us realize that there are still avenues unexplored for the home gamer.

After spending the last few weeks playing with it, I can confidently say the eufyMake E1 UV printer is one of those tools. The elevator pitch is simple: with a UV printer, you can print anything on anything. As you can imagine, the reality is somewhat more complex, but the fact that you can toss a three dimensional object in the chamber and spray it with a high-resolution color image with a few button presses holds incredible creative potential. Enough that the Kickstarter for the $1,700 printer has already raised a mind-boggling $27 million at the time of this writing, with more than a month yet to go before crossing the finish line.

If you’re on the fence about backing the campaign, or just have doubts about whether or not the machine can do what eufyMake claims, I’ll put those concerns to rest right now — it’s the real deal. Even after using the machine for as long as I have, each time a print job ends, I find myself momentary taken aback by just how good the end result is. The technology inside this machine that not only makes these results possible, but makes them so easily obtainable, is truly revolutionary.

That being said, it’s not a perfect machine by any stretch of the imagination. While I never ran into an outright failure while using the eufyMake E1, there’s a fairly long list of issues which I’d like to see addressed. Some of them are simple tweaks which may well get sorted out before the product starts shipping this summer, while others are fundamental to the way the machine operates and could represent an opportunity for competitors.

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A console is shown displaying a system’s startup information, followed by “Booting from Hard Disk …”, “Hello World!” in a green font, and “The keyboard is working!”

A Forth OS In 46 Bytes

May 27, 2025 by 27 Comments

It’s not often that we can include an operating system in a Hackaday article, but here’s the full 46-byte source of [Philippe Brochard]’s 10biForthOS in 8086 opcodes:

50b8 8e00 31d8 e8ff 0017 003c 0575 00ea
5000 3c00 7401 eb02 e8ee 0005 0588 eb47
b8e6 0200 d231 14cd e480 7580 c3f4

Admittedly, this is quite a minimal operating system. It’s written for the Intel 8086, and consists of a Forth implementation with only two instructions: compile (1) and execute (0). It can receive commands over a serial connection or from a keyboard. This allows a host computer to load more complex software onto it, one byte at a time. In particular, [Philippe] provides instructions for loading more advanced compilers, such as subleq-eForth for a more complete Forth implementation, or SectorC for C programming. He’s also written a 217-byte port of the OS to Linux Intel x64.

[Philippe] doesn’t take a strong stance on whether this should technically qualify as a Forth implementation, given that the base implementation lacks stacks, dictionaries, and the ability to define words. However, it does have an outer and inner interpreter, the ability to compile and execute code, and most importantly, “the simplicity and hacky feeling of Forth.”

[Philippe] writes that this masterpiece of minimalism continues the tradition of the minimal Forth implementations we’ve covered before. We’ve even seen Forth run on an Arduino.

Window Shade Motor

Automated Blinds Opener On The Cheap

May 27, 2025 by 7 Comments

We love seeing hacks that involve salvaging parts from what you have on hand to make a new project work, and this project is a great example of that. [Simon], in a quick weekend build, created an automated blinds opener using parts he had available.

The project began with the desire to have his blinds open slowly and silently, gradually letting in more light. To accomplish this, a few key components were needed, including a motor with a gearbox to provide the torque required to actuate the blinds and a magnetic encoder to track their progress. To isolate vibrations and keep the system silent, the motor is mounted using a silicone motor mount that he salvaged from a broken water flosser.

The printed holder for the magnetic encoder is a nice touch.

To mount the motor to the wall near the window, he used some 3D printed parts. A clever combination of surgical silicone tubing and silicone tape attaches the motor to the window blind shaft while limiting vibration transfer, keeping things quiet. [Simon] advises against using magnetic encoders as he did, noting that while he had them on hand and made them work, the magnetic shaft’s misalignment with the encoders makes it a less-than-ideal approach. Nevertheless, he got it working.

Automating blinds is a fairly common project around these parts, made all the more accessible with clever 3D printed mechanisms. We’ve even seen variations that can be used in rentals, dorms, and other places were permanent modifications need to be avoided.

Two hands soldering components on a purpble PCB

Vintage Intel 8080 Runs On A Modern FPGA

May 26, 2025 by 5 Comments

If you’re into retro CPUs and don’t shy away from wiring old-school voltages, [Mark]’s latest Intel 8080 build will surely spark your enthusiasm. [Mark] has built a full system board for the venerable 8080A-1, pushing it to run at a slick 3.125 MHz. Remarkable is that he’s done so using a modern Microchip FPGA, without vendor lock-in or proprietary flashing tools. Every step is open source.

Getting this vintage setup to work required more than logical tinkering. Mark’s board supplies the ±5 V and +12 V rails the 8080 demands, plus clock and memory interfacing via the M2GL005-TQG144I FPGA. The design is lean: two-layer PCB, basic level-shifters, and a CM32 micro as USB-to-UART fallback. Not everything went smoothly: incorrect footprints, misrouted gate drivers, thermal runaway in the clock section; but he managed to tackle it.

What sets this project apart is the resurrection of a nearly 50-year-old CPU. It’s also, how thoroughly thought-out the modern bridge is—from bitstream loading via OpenOCD to clever debugging of crystal oscillator drift using a scope. [Mark]’s love of the architecture and attention to low-level detail makes this more than a show-off build.
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A RISC-V Operating System Instruction Manual

May 26, 2025 by 1 Comment

To some, an operating system is a burden or waste of resources, like those working on embedded systems and other low-power applications. To others it’s necessary, abstracting away hardware so that higher-level programming can be done. For most people it’s perhaps not thought of at all. But for a few, the operating system is the most interesting piece of software running on a computer and if you’d like to investigate what makes this often overlooked aspect of computer science interesting, take a look at this course on operating systems from Cornell University.

The operating system itself is called Earth and Grass Operating System because it splits the functionality of the operating system into three separate parts. The Earth layer involves dealing with hardware, the Grass layer involves hardware-independent aspects, and a third application layer implements other key operating system features. It’s built for a RISC-V processor, since that instruction set is completely open source and transparent about what it’s doing. It’s also incredibly small, coming in at around 2000 lines of code. The course covers nine areas, with the first six being core operating system functions and the remaining three covering more advanced operating system concepts.

For understanding the intricacies and sometimes mysterious ways that operating systems work, a course like this can go a long way into unraveling those mysteries and developing a deeper understanding of how it brings the hardware to work for higher-level software. We actually featured this operating system two years ago, before this course was created, which covers this project for those who like to take a more self-directed approach, or simply want a lightweight OS for a RISC-V system.