Astro Pi Mk II, The New Raspberry Pi Hardware Headed To The Space Station

September 22, 2021 by Tom Nardi 22 Comments

Back in 2015, European Space Agency (ESA) astronaut Tim Peake brought a pair of specially equipped Raspberry Pi computers, nicknamed Izzy and Ed, onto the International Space Station and invited students back on Earth to develop software for them as part of the Astro Pi Challenge. To date, more than 50,000 young people have had their code run on one of the single-board computers; making them arguably the most popular, and surely the most traveled, Raspberry Pis in the solar system.

While Izzy and Ed are still going strong, the ESA has decided it’s about time these veteran Raspberries finally get the retirement they’re due. Set to make the journey to the ISS in December aboard a SpaceX Cargo Dragon, the new Astro Pi MK II hardware looks quite similar to the original 2015 version at first glance. But a peek inside its 6063-grade aluminium flight case reveals plenty of new and improved gear, including a Raspberry Pi 4 Model B with 8 GB RAM.

The beefier hardware will no doubt be appreciated by students looking to push the envelope. While the majority of Python programs submitted to the Astro Pi program did little more than poll the current reading from the unit’s temperature or humidity sensors and scroll messages for the astronauts on the Astro Pi’s LED matrix, some of the more advanced projects were aimed at performing legitimate space research. From using the onboard camera to image the Earth and make weather predictions to attempting to map the planet’s magnetic field, code submitted from teams of older students will certainly benefit from the improved computational performance and expanded RAM of the newest Pi.

As with the original Astro Pi, the ESA and the Raspberry Pi Foundation have shared plenty of technical details about these space-rated Linux boxes. After all, students are expected to develop and test their code on essentially the same hardware down here on Earth before it gets beamed up to the orbiting computers. So let’s take a quick look at the new hardware inside Astro Pi MK II, and what sort of research it should enable for students in 2022 and beyond.

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Mechanisms Behind Vaccine Side-Effects: The Science That Causes That Sore Arm

September 21, 2021 by Maya Posch 85 Comments

After receiving a vaccination shot, it’s likely that we’ll feel some side-effects. These can range from merely a sore arm to swollen lymph nodes and even a fever. Which side-effects to expect depend on the exact vaccine, with each type and variant coming with its own list of common side-effects. Each person’s immune system will also react differently, which makes it hard to say exactly what one can expect after receiving the vaccination.

What we can do is look closer at the underlying mechanisms that cause these side-effects, to try and understand why they occur and how to best deal with them. Most relevant here for the initial response is the body’s innate immune system, with dendritic cells generally being among the first to come into contact with the vaccine and to present the antigen to the body’s adaptive immune system.

Key to the redness, swelling, and fever are substances produced by the body which include various cytokines as well as prostaglandin, producing the symptoms seen with inflammation and injury.

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Farewell Sir Clive Sinclair; Inspired A Generation Of Engineers

September 16, 2021 by Jenny List 74 Comments

It is with sadness that we note the passing of the British writer, engineer, home computer pioneer, and entrepreneur, Sir Clive Sinclair, who died this morning at the age of 81 after a long illness. He is perhaps best known among Hackaday readers for his ZX series of home computers from the 1980s, but over a lifetime in the technology industry there are few corners of consumer electronics that he did not touch in some way.

Sinclair’s first career in the 1950s was as a technical journalist and writer, before founding the electronics company Sinclair Radionics in the 1960s. His output in those early years was a mixture of miniature transistor radios and Hi-Fi components, setting the tone for decades of further tiny devices including an early LED digital watch at the beginning of the 1970s, miniature CRT TVs in the ’70s and ’80s, and another tiny in-ear FM radio which went on sale in the ’90s.

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The Many Ways To Solve Your Enclosure Problems

September 15, 2021 by Bob Baddeley 63 Comments

Most projects around here involve some sort of electronics, and some sort of box to put them in. The same is true of pretty much all commercially available electronic products as well.

Despite that, selecting an enclosure is far from a solved problem. For simple electronics it’s entirely possible to spend more time getting the case just right than working on the circuit itself. But most of the time we need to avoid getting bogged down in what exactly will house our hardware.

The array of options available for your housing is vast, and while many people default to a 3D printer, there are frequently better choices. I’ve been around the block on this issue countless times and wanted to share the options as I see them, and help you decide which is right for you. Let’s talk about enclosures!

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Monoclonal Antibodies: The Guided Missiles Of Medicine

September 15, 2021 by Dan Maloney 11 Comments

Whenever anyone mentions the word “antibodies” these days, it’s sure to grab your attention. Thoughts generally flow to the human immune system and the role it plays in the ongoing COVID-19 pandemic, and to how our bodies fight off disease in general. The immune system is complex in the extreme, but pretty much everyone knows that antibodies are part of it and that they’re vital to the ability of the body to recognize and neutralize invaders like bacteria and viruses.

But as important as antibodies are to long-term immunity and the avoidance of disease, that’s far from all they’re good for. The incredible specificity of antibodies to their target antigens makes them powerful tools for biological research and clinical diagnostics, like rapid COVID-19 testing. The specificity of antibodies has also opened up therapeutic modalities that were once the stuff of science-fiction, where custom-built antibodies act like a guided missile to directly attack not only a specific protein in the body, but sometimes even a specific part of a protein.

Making these therapies work, though, requires special antibodies: monoclonal antibodies. These are very much in the news recently, not only as a possible treatment for COVID-19 but also to treat everything from rheumatoid arthritis to the very worst forms of cancer. But what exactly are monoclonal antibodies, how are they made, and how do they work?

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The World’s First Autonomous Electric Cargo Ship Is Due To Set Sail

September 14, 2021 by Lewin Day 55 Comments

Maritime shipping is big business, with gigantic container ships responsible for moving the vast majority of the world’s goods from point A to points B, C and D. Of course, there’s a significant environmental impact from all this activity, something ill befitting the cleaner, cooler world we hope the future will be. Thus, alternatives to the fossil fuel burning ships of old must be found. To that end, Norwegian company Yara International has developed a zero-emission ship by the name of Yara Birkeland, which aims to show the way forward into a world of electric, autonomous sea transport.

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Pining For A De-Googled Smartphone

September 2, 2021 by Bryan Cockfield 89 Comments

Last summer in the first swings of the global pandemic, sitting at home finally able to tackle some of my electronics projects now that I wasn’t wasting three hours a day commuting to a cubicle farm, I found myself ordering a new smartphone. Not the latest Samsung or Apple offering with their boring, predictable UIs, though. This was the Linux-only PinePhone, which lacks the standard Android interface plastered over an otherwise deeply hidden Linux kernel.

As a bit of a digital privacy nut, the lack of Google software on this phone seemed intriguing as well, and although there were plenty of warnings that this was a phone still in its development stages it seemed like I might be able to overcome any obstacles and actually use the device for daily use. What followed, though, was a challenging year of poking, prodding, and tinkering before it got to the point where it can finally replace an average Android smartphone and its Google-based spyware with something that suits my privacy-centered requirements, even if I do admittedly have to sacrifice some functionality.

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