Open-Source Insulin: Biohackers Aiming For Distributed Production

August 23, 2021 by Dan Maloney 74 Comments

When you’ve got a diabetic in your life, there are few moments in any day that are free from thoughts about insulin. Insulin is literally the first coherent thought I have every morning, when I check my daughter’s blood glucose level while she’s still asleep, and the last thought as I turn out the lights, making sure she has enough in her insulin pump to get through the night. And in between, with the constant need to calculate dosing, adjust levels, add corrections for an unexpected snack, or just looking in the fridge and counting up the number of backup vials we have on hand, insulin is a frequent if often unwanted intruder on my thoughts.

And now, as my daughter gets older and seeks like any teenager to become more independent, new thoughts about insulin have started to crop up. Insulin is expensive, and while we have excellent insurance, that can always change in a heartbeat. But even if it does, the insulin must flow — she has no choice in the matter. And so I thought it would be instructional to take a look at how insulin is made on a commercial scale, in the context of a growing movement of biohackers who are looking to build a more distributed system of insulin production. Their goal is to make insulin affordable, and with a vested interest, I want to know if they’ve got any chance of making that goal a reality.

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Tiny ball magnets implanted in muscles could provide much better control over prosthetics.

Magnets Could Give Prosthetic Control A Leg Up

August 21, 2021 by Kristina Panos 6 Comments

Today, prostheses and exoskeletons are controlled using electromyography. In other words, by recording the electrical activity in muscles as they contract. It’s neither intuitive nor human-like, and it really only shows the brain’s intent, not the reality of what the muscle is doing.

Researchers at MIT’s Media Lab have figured out a way to use magnets for much more precise control, and they’re calling it magnetomicrometry (MM). By implanting pairs of tiny ball magnets and tracking their movement with magnetic sensors, each muscle can be measured individually and far more accurately than with electromyography.

After embedding pairs of 3mm diameter ball magnets into the calves of turkeys, the researchers were able to detect muscle movement in three milliseconds, and to the precision of thirty-seven microns, which is about the width of a human hair. They hope to try MM on humans within the next couple of years. It would be a great solution overall if it works out, because compared with the electromyography method, MM is cheaper, less invasive, and potentially permanent. Couple MM with a new type of amputation surgery called AMI that provides a fuller range of motion, less pain overall, and finer control of prosthetics, and the future of prostheses and rehabilitation looks really exciting. Be sure to check out the video after the break.

There’s more than one way to control prostheses, such as deep learning and somatosensory stimulation.

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Cobbled together proof-of-concept vaccination verification system, showing a dot-matrix receipt printer, a webcam for QR code scanning, and an old laptop running the software

Manitoban Makes Open Software Demo Of Proprietary Vaccine Verification Systems

August 19, 2021 by Chris Lott 31 Comments

[Mark Jenkins] wasn’t impressed with the Covid 19 vaccination verification systems that restaurants in Manitoba are required to use. Patrons must present a QR code, which must be verified by a mobile app available only from Apple or Google. With help from his local hackerspace, he came up with a bash script solution requiring only kilobytes vs the 50 MB of the mobile apps. [Mark] isn’t pleased with the exclusivity of the apps availability and the lack of an open API. His concern isn’t entirely theoretical, either — Google mysteriously pulled their app from the Play Store for over a week.

The interim result, shown in the video below, is a demonstration system called Alexandra. It consists of a receipt printer, a webcam being used as a QR scanner, and a 2005-era laptop running the script. This is merely a proof of concept, as [Mark] clearly notes. There is still some work to be done — for example, the method used to authenticate with the Google server is transient. But eventually [Mark] hopes to have a free software alternative soon, suitable for restaurant owners to use in their establishments.

What kinds of vaccination verifications systems, if any, are used in your part of the world? Is the system open or proprietary? Let us know in the comments below.

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Two views of the M19O2 oxygen concentrator

Design Improvements Make DIY Oxygen Concentrator Even Better

August 18, 2021 by Dan Maloney 8 Comments

A lot of projects we feature on these pages are of the “one and done” variety — tactical builds that serve a specific purpose with little need for further development. Some projects, though, come out as rough prototypes and then go through multiple rounds of refinement, a process we really enjoy tracking down and following. And when the project is something as important as an oxygen concentrator that can be built and maintained easily, all the better.

The need for cheap oxygen concentrators stems directly from the COVID-19 pandemic, which suggested that high-flow oxygen therapy was a better choice than invasive intubations and mechanical ventilation. But medical-grade oxygen isn’t always easy to come by in all parts of the world, so easily built oxygen concentrators, which rely on the nitrogen-adsorbing properties of the mineral zeolite, are meant to fill the gaps. Early versions of the M19O2 and the related OxyKit concentrator, had a very homebrew feel to them, built on wooden frames as they were. And while the rustic nature of the early builds didn’t detract from their utility, the hackers behind them, including our own [Anool Mahidharia], have been making incremental improvements aimed at not only making the devices work better, but also making them easier to build.

The hackers at Maker’s Asylum have done a fantastic job at documenting their work, with everything posted to a GitHub repo so that anyone can undertake a build. And really, for something as important as making oxygen when it’s needed, there’s really no reason not to give this a try.

A Stress Monitor Designed Specifically To Help You Work From Home

August 11, 2021 by Orlando Hoilett 10 Comments

There are quite a bit of mixed emotions regarding working from home. Some people love it and are thriving like they haven’t before, but others are having a bit of a hard time with it all. [Brandon] has been working from home for the last 12 years, but even after so many years of managing this type of work culture, he admits that it can still be a little stressful. He says he doesn’t take enough time in between tasks to simply relax and to breathe a little and the day-to-day minutia of his work can drive his stress level up if he doesn’t take some time to calm himself. He figured he could make something to monitor his stress level and remind himself to take a break and the results are pretty impressive.

He develops a system to monitor his heart rate and the ambient noise level in his room and uses these metrics as a measure of stress. If his heart rate or the ambient noise level goes above a certain threshold, then he sends himself a text message reminding himself to relax and take a break. You’ve probably seen people use heart rate as a measure of stress already, but you’re probably less familiar with using sound. [Brandon] basically thought the sound sensor would detect if he starts ranting for prolonged periods of time or if he’s in a Zoom meeting that gets too heated. We thought that was pretty neat.

[Brandon] used an off-the-shelf chest strap heart rate monitor to save himself a bit of time in trying to build his own. The device sends heart rate data to an nRF52840 over Bluetooth and then pushes the data to the cloud using a Blues Wireless Notecard. The Notecard also offers data encryption which gave [Brandon] some added peace of mind knowing his biometric data wasn’t floating around in the cloud without any sort of protection. This certainly isn’t medical-grade encryption, but it gave him a bit of comfort, nonetheless. All that data is processed in his custom-designed web app and when the appropriate thresholds are reached, he sends a text message to himself using Twilio reminding him to relax and unwind for a bit.

For his next iteration, [Brandon] might try making his own heart rate monitor. But until then, stay safe everybody, and remember to take a break whenever you need it.

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Charles Lindbergh The Famous… Inventor?

August 10, 2021 by Al Williams 25 Comments

Most people remember Charles Lindbergh for his non-stop solo flight across the Atlantic which made him an international celebrity. If you are a student of history, you might also know he was at the center of a very controversial trial surrounding the kidnapping of his child or even that he had a dance named after him. But did you know he was also the co-inventor of a very important medical device? Turns out, medicine can thank Lindbergh for the creation of the perfusion pump.

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Permanent Artificial Hearts: Long-Sought Replacements May Not Be Far Away

August 9, 2021 by Dan Maloney 44 Comments

The number of artificial prosthetic replacement parts available for the human body is really quite impressive. From prosthetic eyes to artificial hips and knees, there are very few parts of the human body that can’t be swapped out with something that works at least as well as the original, especially given that the OEM part was probably in pretty tough shape in the first place.

But the heart has always been a weak spot in humans, in part because of the fact that it never gets to rest, and in part because all things considered, we modern humans don’t take really good care of it. And when the heart breaks down past the point where medicine or surgery can help, we’re left with far fewer alternatives than someone with a bum knee would face. The fact is that the best we can currently hope for is a mechanical heart that lets a patient live long enough to find a donor heart. But even then, tragedy must necessarily attend, and someone young and healthy must die so that someone else may live.

A permanent implantable artificial heart has long been a goal of medicine, and if recent developments in materials science and electrical engineering have anything to say about it, such a device may soon become a reality. Heart replacements may someday be as simple as hip replacements, but getting to that point requires understanding the history of mechanical hearts, and why it’s not just as simple as building a pump.

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