brain

40 Articles

Gene Therapy Aims To Slow Huntington’s Disease To A Crawl

November 11, 2025 by 21 Comments

Despite the best efforts of modern medicine, Huntington’s disease is a condition that still comes with a tragic prognosis. Primarily an inherited disease, its main symptoms concern degeneration of the brain, leading to issues with motor control, mood disturbance, with continued degradation eventually proving fatal.

Researchers have recently made progress in finding a potential treatment for the disease. A new study has indicated that an innovative genetic therapy could hold promise for slowing the progression of the disease, greatly improving patient outcomes.

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The Strange Depression Switch Discovered Deep Inside The Brain

November 10, 2025 by 49 Comments

As humans, we tend to consider our emotional states as a direct response to the experiences of our lives. Traffic may make us frustrated, betrayal may make us angry, or the ever-grinding wear of modern life might make us depressed.

Dig into the science of the brain, though, and one must realize that our emotional states are really just electrical signals zinging around our neurons. And as such, they can even be influenced by direct electrical stimulation.

One group of researchers found this out when they inadvertently discovered a “switch” that induced massive depression in a patient in mere seconds. For all the complexities of the human psyche, a little electricity proved more than capable of swaying it in an instant.

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Researchers Create A Brain Implant For Near-Real-Time Speech Synthesis

May 1, 2025 by 17 Comments

Brain-to-speech interfaces have been promising to help paralyzed individuals communicate for years. Unfortunately, many systems have had significant latency that has left them lacking somewhat in the practicality stakes.

A team of researchers across UC Berkeley and UC San Francisco has been working on the problem and made significant strides forward in capability. A new system developed by the team offers near-real-time speech—capturing brain signals and synthesizing intelligible audio faster than ever before.

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Brain on a chip setup with a hand and a dropper

Gray Matter On A Chip: Building An Artificial Brain With Luminol

December 5, 2024 by 11 Comments

Ever wondered if you could build a robot controlled by chemical reactions? [Marb] explores this wild concept in his video, merging chemistry and robotics in a way that feels straight out of sci-fi. From glowing luminol reactions to creating artificial logic gates, [Marb]—a self-proclaimed tinkerer—takes us step-by-step through crafting the building blocks for what might be the simplest form of a chemical brain.

In this video, the possibilities of an artificial chemical brain take centre stage. It starts with chemical reactions, including a fascinating luminol-based clock reaction that acts as a timer. Then, a bionic robot hand makes its debut, complete with a customised interface bridging the chemical and robotic worlds. The highlight? Watching that robotic hand respond to chemical reactions!

The project relies on a “lab-on-a-chip” approach, where microfluidics streamline the processes. Luminol isn’t just for forensic TV shows anymore—it’s the star of this experiment, with resources like this detailed explanation breaking down the chemistry. For further reading, New Scientist has you covered.

We’ve had interesting articles on mapping the human brain before, one on how exactly brains might work, or even the design of a tiny robot brain. Food for thought, or in other words: stirring the gray matter.

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Print Your Own Brain Lamp From MRI Data

December 1, 2023 by 12 Comments

MRIs generally fall somewhere on the scale from boring to stressful depending on why you’re having one and how claustrophobic you get. Regardless, they’re a wonderful diagnostic tool and they’ve saved thousands if not millions of lives over the years. In a fun use of the technology, [mandalaFractals] has shown us how to make a 3D-printed brain lamp using an MRI scan of the head.

The build starts with an off-the-shelf lamp base and a smart LED bulb as the light source, though you could swap those out as desired for something like a microcontroller, a USB power supply, and addressable LEDs if you were so inclined. The software package Slicer is then used to take an MRI brain scan and turn it into something that you can actually 3D print. It’ll take some cleaning up to remove artifacts and hollow it out, but it’s straightforward enough to get a decent brain model out of the data. Alternatively, you can use someone else’s if you don’t have your own scan. Then, all you have to do is print it in a couple of halves, and pop it on the lamp base, and you’re done!

It’s a pretty neat build. Who wouldn’t love telling their friends that their new brain lamp was an accurate representation of their own grey noodles, after all? It could be a fun gift next time Halloween rolls around, too!

Meanwhile, if you’ve got your own MRI hacks that you’ve been cooking up, don’t hesitate to let us know!

Microbubbles And Ultrasound: Getting Drugs Through The Blood-Brain Barrier

May 16, 2023 by 19 Comments

The brain is a rather important organ, and as such, nature has gone to great lengths to protect it. The skull provides physical protection against knocks and bumps, but there’s a lesser-known defense mechanism at work too: the blood-brain barrier. It’s responsible for keeping all the nasty stuff – like bacteria, viruses, and weird chemicals – from messing up your head.

The blood-brain barrier effectively acts as a filter between the body’s circulatory system and the brain. However, it also frustrates efforts to deliver drugs directly to the brain for treating conditions like brain tumors. Now, scientists have developed a new technique that may allow critical life saving drugs to get through the barrier with the help of ultrasound technology. 

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MRI Resolution Progresses From Millimeters To Microns

April 20, 2023 by 15 Comments

Neuroscientists have been mapping and recreating the nervous systems and brains of various animals since the microscope was invented, and have even been able to map out entire brain structures thanks to other imaging techniques with perhaps the most famous example being the 302-neuron brain of a roundworm. Studies like these advanced neuroscience considerably but even better imaging technology is needed to study more advanced neural structures like those found in a mouse or human, and this advanced MRI machine may be just the thing to help gain better understandings of these structures.

A research team led by Duke University developed this new MRI technology using an incredibly powerful 9.4 Tesla magnet and specialized gradient coils, leading to an image resolution an impressive six orders of magnitude higher than a typical MRI. The voxels in the image measure at only 5 microns compared to the millimeter-level resolution available on modern MRI machines, which can reveal microscopic details within brain tissues that were previously unattainable. This breakthrough in MRI resolution has the potential to significantly advance understanding of the neural networks found in humans by first studying neural structures in mice at this unprecedented detail.

The researchers are hopeful that this higher-powered MRI microscope will lead to new insights and translate directly into advancements healthcare, and presuming that it can be replicated, used on humans safely, and becomes affordable, we would expect it to find its way into medical centers as soon as possible. Not only that, but research into neuroscience has plenty of applications outside of healthcare too, like the aforementioned 302-neuron brain of the Caenorhabditis elegans roundworm which has been put to work in various robotics platforms to great effect.

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