The Vaccine Factory Inside You: RNA Vaccine Basics

May 4, 2020 by Dan Maloney 19 Comments

As the world pulls back from the acute phase of the COVID-19 pandemic, it enters what will be perhaps a more challenging time: managing the long-term presence of the SARS-CoV-2 virus that causes the disease. In the roughly two-century history of modern vaccination practices, we’ve gotten pretty good at finding ways to protect ourselves from infectious diseases, and there’s little doubt that we’ll do the same for SARS-CoV-2. But developing a vaccine against any virus or bacterium takes time, and in a pandemic situation, time is exactly what’s at a premium.

In an effort to create an effective vaccine against this latest viral threat, scientists and physicians around the world have been taking a different approach to inoculation. Rather than stimulating the immune system in the usual way with a weakened sample of the virus, they’re trying to use the genetic material of the virus to stimulate an immune response. These RNA vaccines are a novel approach to a novel infection, and understanding how they work will be key to deciding whether they’ll be the right way to attack this pandemic.

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ESP32-S2 Hack Chat With Adafruit

May 4, 2020 by Dan Maloney 23 Comments

Join us on Wednesday, May 6 at noon Pacific for the ESP32-S2 Hack Chat with Limor “Ladyada” Fried and Scott Shawcroft!

When Espressif released the ESP8266 microcontroller back in 2014, nobody could have predicted how successful the chip was to become. While it was aimed squarely at the nascent IoT market and found its way into hundreds of consumer devices like smart light bulbs, hackers latched onto the chip and the development boards it begat with gusto, thanks to its powerful microcontroller, WiFi, and lots of GPIO.

The ESP8266 was not without its problems, though, and security was always one of them. The ESP32, released in 2016, addressed some of these concerns. The new chip added another CPU core, a co-processor, Bluetooth support, more GPIO, Ethernet, CAN, more and better ADCs, a pair of DACs, and a host of other features that made it the darling of the hacker world.

Now, after being announced in September of 2019, the ESP32-S2 is finally making it into hobbyist’s hands. On the face of it, the S2 seems less capable, with a single core and neither Bluetooth nor Ethernet. But with a much faster CPU, scads more GPIO, more ADCs, a RISC-V co-processor, native USB, and the promise of very low current draw, it could be that the ESP32-S2 proves to be even more popular with hobbyists as it becomes established.

To talk us through the new chip’s potential, Limor “Ladyada” Fried and Scott Shawcroft, both of Adafruit Industries, will join us on the Hack Chat. Come along and learn everything you need to know about the ESP32-S2, and how to put it to work for you.

Our Hack Chats are live community events in the Hackaday.io Hack Chat group messaging. This week we’ll be sitting down on Wednesday, May 6 at 12:00 PM Pacific time. If time zones have got you down, we have a handy time zone converter.

Click that speech bubble to the right, and you’ll be taken directly to the Hack Chat group on Hackaday.io. You don’t have to wait until Wednesday; join whenever you want and you can see what the community is talking about.
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Hackaday Links: May 3, 2020

May 3, 2020 by Dan Maloney 7 Comments

In a sign of the times, the Federal Communications Commission has officially signed off on remote testing sessions for amateur radio licensing in the United States. Testing in the US is through the Volunteer Examiner Coordinator program, which allows teams of at least three Volunteer Examiners to set up in-person testing sessions where they proctor amateur radio licensing exams. The VEs take their jobs very seriously and take pride in offering exam sessions on a regular schedule, so when social distancing rules made their usual public testing venues difficult to access, many of them quickly pivoted to remote testing using teleconferencing applications. Here’s hoping that more VEs begin offering remote testing sessions.

Another aspect of life changed by COVID-19 and social distancing rules has been the simple pleasure of a trip to the museum. And for the museums themselves, the lack of visitors can be catastrophic, both in terms of fulfilling their educational and research missions and through the lack of income that results. To keep the flame alive in a fun way, Katrina Bowen from The Centre for Computing History in Cambridge has recreated her museum in loving detail in Animal Crossing: New Leaf. For being limited to what’s available in the game, Katrina did a remarkable job on the virtual museum; we especially like the Megaprocessor wallpaper. She even managed to work in that staple last stop of every museum, the gift shop.

To the surprise of few, “spatial computing” startup Magic Leap has announced that it is laying off half its workforce as it charts a new course. The company, which attracted billions in funding based on its virtual retinal display technology, apparently couldn’t sell enough of their Magic Leap One headsets to pay the bills. The company is swiveling to industrial users, which honestly seems like a better application for their retinal display technology than the consumer or gaming markets.

And finally, as if 2020 hasn’t been weird enough already, the Department of Defense has officially released videos of what it calls “unidentified aerial phenomena.” These videos, taken from the head-up displays of US Navy fighter jets, had previously been obtained by private parties and released to the public. Recorded between 2004 and 2015, the videos appear to show objects that are capable of extremely high-speed flight and tight maneuvers close to the surface of the ocean. We find the timing of the release suspicious, almost as if the videos are intended to serve as a distraction from the disturbing news of the day. We want to believe we’re not alone, but these videos don’t do much to help.

Hardware Hacker’s Marie Kondo: How Many LM386s Is Too Many?

May 2, 2020 by Elliot Williams 57 Comments

We’re running a contest on Making Tech at Home: building projects out of whatever you’ve got around the house. As a hacker who’s never had a lab outside of my apartment, house, or hackerspace, I had to laugh at the premise. Where the heck else would I hack?

The idea is that you’re constrained to whatever parts you’ve got on hand. But at the risk of sounding like Scrooge McDuck sitting on a mountain of toilet paper, I’ve got literally hundreds of potentiometers in my closet, a couple IMUs, more microcontrollers than you can shake a stick at, and 500 ml of etching solution waiting for me in the bathroom. Switches, motors, timing belts, nichrome wire…maybe I should put in an order for another kilogram of 3D printer filament. In short, unless it’s a specialty part or an eBay module, I’m basically set.

But apparently not everyone is so well endowed. I’ve heard rumors of people who purchase all of the parts for a particular project. That ain’t me. The guru of household minimalism asks us to weigh each object in our possession and ask “does it spark joy?”. And the answer, when I pull out the needed 3.3 V low-dropout regulator and get the project built now instead of three days from now, is “yes”.

And I’m not even a hoarder. (I keep telling myself.) The rule that keeps me on this side of sanity: I have a box for each type of part, and they are essentially fixed. When no more motors fit in the motor box, no more motors are ordered, no matter how sexy, until some project uses enough of them to free up space. It’s worked for the last 20 years, long before any of us had even heard of Marie Kondo.

So if you also sit atop a heap of VFD displays like Smaug under the Lonely Mountain, we want to see what you can do. If you do win, Digi-Key is sending you a $500 goodie box to replenish your stash. But even if you don’t win, you’ve freed up space in the “Robot Stuff” box. That’s like winning, and you deserve some new servos. Keep on hacking!

Hackaday Podcast 065: Game Boy Hacks Galore, Cable Robo Elbow, Pi Cam Solargraphy, And The Deepest Sub Is Crushing It

May 1, 2020 by Mike Szczys 1 Comment

Hackaday editors Mike Szczys and Elliot Williams cover the hacks that made us happy over the past week. There’s an incredible cable-driven robotic elbow hack whose quality is only eclipsed by the fantastic explanation of how it works (like a block and tackle). Getting data like WiFi credentials into your embedded project may be just a blinking Android app away. Try your hand at digital solargraphy with creative use of f-stop and post processing. And Mike ogles an RC F-35 project while Elliot goes gaga for the deepest of all submarine designs.

Take a look at the links below if you want to follow along, and as always tell us what you think about this episode in the comments!

Take a look at the links below if you want to follow along, and as always, tell us what you think about this episode in the comments!

Direct download (60 MB or so.)

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This Week In Security: Firewall 0-day, Apple’s Response, And An Android Bluetooth Bug

May 1, 2020 by Jonathan Bennett 8 Comments

Sophos firewall appliances are actively being attacked by a 0-day exploit chain that originates with a SQL injection. That injection is a nasty one, as it can be launched from the WAN user portal. The observed attack used that vulnerability to inject a shell command into the device database, where it would eventually be run automatically. If you have an affected Sophos device, go check that the hotfix was automatically installed.

While the vulnerability was a bad one, Sophos’ response here is laudable. They publicly disclosed the attack less than 24 hours after they were notified of it’s existence in the wild, and began rolling a fix out within three days. Additionally, Sophos engineers did a really detailed write-up (linked above) giving us all the details of the attack. The hotfix that closes the vulnerability also attempts to clean up the infection, although there are some additional manual steps that are suggested if your device was compromised. Continue reading “This Week In Security: Firewall 0-day, Apple’s Response, And An Android Bluetooth Bug” →

3D Printering: Will A Resin Printer Retire Your Filament-based One?

April 30, 2020 by Donald Papp 25 Comments

Adding a resin printer to one’s workbench has never looked so attractive, nor been so affordable. Complex shapes with effortlessly great detail and surface finish? Yes, please! Well, photos make the results look effortless, anyway. Since filament-based printers using fused deposition modeling (FDM) get solid “could be better” ratings when it comes to surface finish and small detail resolution, will a trusty FDM printer end up retired if one buys a resin printer?

The short answer is this: for users who already use FDM, a resin-based stereolithography (SLA) printer is not likely to take over. What is more likely to happen is that the filament printer continues to do the same jobs it is good at, while the resin printer opens some wonderful new doors. This is partly because those great SLA prints will come at a cost that may not always justify the extra work.

Let’s go through what makes SLA good, what it needs in return, and how it does and doesn’t fit in with FDM.

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