You might have heard of the cochlear implant. It’s an electronic device also referred to as a neuroprosthesis, serving as a bionic replacement for the human ear. These implants have brought an improved sense of hearing to hundreds of thousands around the world.
However, the cochlear implant isn’t the only game in town. The auditory brain stem implant is another device that promises to bring a sense of sound to those without it, albeit by a different route.
When you think of high-throughput ptychographic cytometry (wait, you do think about high throughput ptychographic cytometry, right?) does it bring to mind something you can hack together from an old Blu-ray player, an Arduino, and, er, some blood? Apparently so for [Shaowei Jiang] and some of his buddies in this ACS Sensors Article.
For those of you who haven’t had a paper accepted by the American Chemical Society, we should probably clarify things a bit. Ptychography is a computational method of microscopic imaging, and cytometry has to do with measuring the characteristics of cells. Obviously.
This is definitely what science looks like.
Anyway, if you shoot a laser through a sample, it diffracts. If you then move the sample slightly, the diffraction pattern shifts. If you capture the diffraction pattern in each position with a CCD sensor, you can reconstruct the shape of the sample using breathtaking amounts of math.
One hitch – the CCD sensor needs a bunch of tiny lenses, and by tiny we mean six to eight microns. Red blood cells are just that size, and they’re lens shaped. So the researcher puts a drop of their own blood on the surface of the CCD and covers it with a bit of polyvinyl film, leaving a bit of CCD bloodless for reference. There’s an absolutely wild video of it in action here.
To the uninitiated, it might seem like a gimmick to 3D print pharmaceuticals. After all, you take some kind of medicine, pour it in a mold, and you have a pill, right? But researchers and even some commercial companies are 3D printing drugs with unusual chemical or physical properties. For example, pills with braille identification on them or antibiotics with complex drug-release rates. The Universidade de Santiago de Compostela and the University College London can now 3D print pills without relying on a layer-by-layer approach. Instead, the machine produces the entire pill directly.
According to a recent report on the study, there are at least two things holding back printed pills. First, anything medical has to go through rigorous testing for approval in nearly any country. In addition, producing pills at typical 3D printing speeds is uneconomical. This new approach uses multiple beams of light to polymerize an entire tank of resin at once in as little as seven seconds.
With 3D printed drugs, it is possible to tailor release profiles for individual cases and make hybrid drugs such as a French drug that joins anticancer drugs with another drug to manage side effects. Is this a real thing for the future? Will doctors collect enough data to make it meaningful to tailor drugs to patients? Will regulators allow it? For hybrid medicine, is there really an advantage over just taking two pills? Only time will tell.
You probably don’t want to lose a leg, but if you have to there are many options now that were unthinkable not long ago. That is, if you can afford them. A microprocessor knee — a prosthetic with some smarts in it — can run anywhere from $25,000 to well over $100,000. However [Lucas Galey], a PhD candidate at the University of Texas El Paso in a recent paper claims to be able to produce a comparable artificial knee for under $1,000. If the paper is too long to read, Amplitude has a good summary including what it means to people who need them.
Of course, the cost of making something like this is almost incidental. The cost of approvals, testing, and other factors mean that even with about $500 in parts, the retail price would be much higher. Probably not $25,000, though.
It’s a sad statement on the modern world that even civilians are at risk for severe traumatic injuries in the course of going about their lives. And if something unthinkable happens to you or someone you love, here’s hoping both that the injury can be treated, and that someone is nearby who both knows what to do and is properly equipped to do it.
That’s the thinking behind these 3D printed tourniquets, an unfortunate but necessary response to the ongoing war in Ukraine. To get tourniquets into the hands of those trained to use them, [3DPrintingforUkraine] is working on plans for a printable version of the C-A-T, or combat application tourniquet, a lightweight but strong tourniquet that can be rapidly applied, even by victims themselves. The commercial device consists of molded nylon buckles and hook-and-loop fastener bands, along with a very sturdy plastic handle that serves as a windlass that provides the necessary occlusive force when twisted. The 3D printed version’s parts aren’t as streamlined as the commercial unit’s, but they appear to be strong enough to withstand the considerable forces involved. From the look of their site, STL files and instructions for assembly will be available soon.
To be clear, tourniquets should only be applied by someone properly trained to do so. But having ample tourniquets available where traumatic injuries to the extremities are likely to occur can only improve the odds that one will be available when it’s needed. So hats off to [3DPrintingforUkraine] for making the effort to push this forward.
We’ve all had to shake jars of nail polish, model paint, or cell cultures. Mixing paint is easy – but bacteria and cells need to be agitated for hours. Happily, laboratory tube tumblers automate this for us. The swishing action is handled with rotation. The vials are mounted at angles around a wheel. The angular offset means the tubes are inclined as they rise, and declined as they fall. This causes the liquid in the tube to slosh from one side to the other as the wheel rotates. [Sebastian S. Cocioba] aka [ATinyGreenCell] released his plans through Tinkercad and GitHub, and with a name like Sir Tumbalot, we know he must be cultured indeed.
Grab your monocles. Version 2 features a driven wheel lined with magnets to attach tube adapters, and he’s modeled 50mL and twin 15mL tube holders. The attachment points look like a simple beveled rectangle with a magnet pocket, so if you’re feeling vigorous for vials, you can whip up custom sockets and tumble any darn thing. A Trinamic StealthChop chip on a custom PCB controls the pancake stepper, and the whole shebang should cost less than $50USD. We’re wondering what other purposes this modular design could have, like the smallest rock tumbler or resin print rinser.
For all the convenience and indispensability of having access to the sum total of human knowledge in the palm of your hand, the actual process of acquiring and configuring a smartphone can be an incredibly frustrating experience. Standing in those endless queues at the cell phone store, jumping through the administrative hoops, and staring in sticker shock at a device that’s likely to end its life dunked in a toilet all contribute to the frustration.
But for my money, the real trouble starts once you get past all that stuff and start trying to set up the new phone just right. Sure, most phone manufacturers make it fairly easy to clone your old phone onto the new one, but there are always hiccups. And for something that gets as tightly integrated into the workflows of your daily life as cell phones do, that can be a real bummer. Especially when you find out that your shiny new phone can’t do something you absolutely depend on.
