MicroLab reactor setup

Little Pharma On The Prairie

Let’s get the obvious out of the way first — in his DEFCON 32 presentation, [Dr. Mixæl Laufer] shared quite a bit of information on how individuals can make and distribute various controlled substances. This cuts out pharmaceutical makers, who have a history of price-gouging and discontinuing recipes that hurt their bottom line. We predict that the comment section will be incendiary, so if your best argument is, “People are going to make bad drugs, so no one should get to have this,” please disconnect your keyboard now. You would not like the responses anyway.

Let’s talk about the device instead of policy because this is an article about an incredible machine that a team of hackers made on their own time and dime. The reactor is a motorized mixing vessel made from a couple of nested Mason jars, surrounded by a water layer fed by hot and cold reservoirs and cycled with water pumps. Your ingredients come from three syringes and three stepper-motor pumps for accurate control. The brains reside inside a printable case with a touchscreen for programming, interaction, and alerts.

It costs around $300 USD to build a MicroLab, and to keep it as accessible as possible, it can be assembled without soldering. Most of the cost goes to a Raspberry Pi and three peristaltic pumps, but if you shop around for the rest of the parts, you can deflate that price tag significantly. The steps are logical, broken up like book chapters, and have many clear pictures and diagrams. If you want to get fancy, there is room to improvise and personalize. We saw many opportunities where someone could swap out components, like power supplies, for something they had lying in a bin or forego the 3D printing for laser-cut boards. The printed pump holders spell “HACK” when you disassemble them, but we would have gone with extruded aluminum to save on filament.

Several times [⁨Mixæl] brings up the point that you do not have to be a chemist to operate this any more than you have to be a mechanic to drive a car. Some of us learned about SMILES (Simplified Molecular Input Line Entry System) from this video, and with that elementary level of chemistry, we feel confident that we could follow a recipe, but maybe for something simple first. We would love to see a starter recipe that combines three sodas at precise ratios to form a color that matches a color swatch, so we know the machine is working correctly; a “calibration cocktail,” if you will.

If you want something else to tickle your chemistry itch, check out our Big Chemistry series or learn how big labs do automated chemistry.

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Bespoke Implants Are Real—if You Put In The Time

A subset of hackers have RFID implants, but there is a limited catalog. When [Miana] looked for a device that would open a secure door at her work, she did not find the implant she needed, even though the lock was susceptible to cloned-chip attacks. Since no one made the implant, she set herself to the task. [Miana] is no stranger to implants, with 26 at the time of her talk at DEFCON31, including a couple of custom glowing ones, but this was her first venture into electronic implants. Or electronics at all. The full video after the break describes the important terms.

The PCB antenna in an RFID circuit must be accurately tuned, which is this project’s crux. Simulators exist to design and test virtual antennas, but they are priced for corporations, not individuals. Even with simulators, you have to know the specifics of your chip, and [Miana] could not buy the bare chips or find a datasheet. She bought a pack of iCLASS cards from the manufacturer and dissolved the PVC with acetone to measure the chip’s capacitance. Later, she found the datasheet and confirmed her readings. There are calculators in lieu of a simulator, so there was enough information to design a PCB and place an order.

The first batch of units can only trigger the base station from one position. To make the second version, [Miana] bought a Vector Network Analyzer to see which frequency the chip and antenna resonated. The solution to making adjustments after printing is to add a capacitor to the circuit, and its size will tune the system. The updated design works so a populated board is coated and implanted, and you can see an animated loop of [Miana] opening the lock with her bare hand.

Biohacking can be anything from improving how we read our heart rate to implanting a Raspberry Pi.

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Cyberdeck on a table

2023 Cyberdeck Challenge: Modular Cyberdeck Creation Kit

We were fortunate to run into [Sp4m] at DEFCON31 and see his Modular Cyberdeck Creation Kit in person. In fact, he was wearing it around the hallways like a rogue decker in search of fellow runners. Holding the unit feels like a serious tool because of its weight, mainly from the battery. Everything hangs from a single-point sling on a metal handle, probably from the cabinetry aisle, and we could move silently and comfortably. The sling is firearm-rated, which is appropriate since he has a printed Weaver rail on top. It just needs a flashlight/laser combo.

[Sp4m] aims to create printable parts that combine any on-hand materials into a usable cyberdeck. In this iteration, he uses a wired Apple keyboard and trackpad he found in the trash, so we have to assume he works in IT. Most of the trackpad is covered, but enough is accessible to scroll and maneuver the mouse, saving almost six inches. The Steam deck is the current head but is removable so that this hardware collection can work for many USB-C tablets without fuss.

The eye-catching white/orange is no accident and may earn it a top spot in the Icebreaker category of the 2023 Cyberdeck Contest. The judges are currently deliberating, so keep an eye out for an announcement about the winners shortly.

Get Your Leafy Meats

Some of us jokingly refer to our hobbies as “mad science,” but [Justin] from The Thought Emporium could be one Igor away from living up to the jibe. The latest project to come out of the YouTube channel, video also after the break, outlines a map for creating an artificial organism in their new lab. The purpose is to test how far a citizen scientist can push the boundary of bioengineering. The stated goal is to create a swimming entity with a skeleton. The Thought Emporium also has a neuron project in the works, hinting at a potential crossover.

The artifishal [sic] organism has themes at the micro and macro scale. [Justin] says, “Cells are like little nano-robots. Mainly in the sense that they just follow their built-in instructions to the best of their ability.” At the multi-cellular level, the goal is to program something to actuate muscle tissue rhythmically to sustain locomotion. The method for creating living parts is decellularization and recellularization, a technique we heard about at Hackaday Belgrade.

The Thought Emporium is improving upon its protocol which removes cells from their “scaffolding” to repopulate it with the desired type, muscle in this case. Cellular scaffolds retain the shape of whatever they were, so whatever grows on them determines what they become. Once the technique of turning a leaf into muscle fibers is mastered, the next step will be creating bones with a different cell line that will mineralize the scaffold. Optimizing the processes and combining the results may show the world what is possible with the dedication of citizen bioengineers.

Regenerative medicine is looking at replacement human-parts with similar techniques. We are eager to see fish that digest plastic.

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Smart Sphere Or Magnetic Magic

Sometimes a coworker sees something on your desk, and they have to ask, “Where can I get one of those?” and that has to be one of the greatest compliments to a maker. [Greg Zumwalt] nailed it with his “Marblevator Line Follower.” Roboticists will immediately recognize a black line on a white surface, but this uses hidden mechanics instead of light/dark sensors. Check out the video after the break to see the secrets, or keep bearing with us.

Inside the cylinder is a battery, charging circuit, inductive receiving coil, and a motor turning a magnet-laden arm beneath the cap. The overall effect is an illusion to convince people that the marble has a mind of its own. You can pick up the cylinder, and it keeps moving as expected from an autonomous bot. The black line is actually a groove, so the bearing follows a curvy course without any extra movements from the magnets within. The two-tone look is super-clean, but the whimsy of a “smart bearing” makes this an all-around winner.

“Marblevator Line Follower” is not the first Marblevator we featured, and we love our bouncing-bearing baubles and music-making machines.

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Jigsaw Puzzles Are Defeated

To some folx, puzzles are the ultimate single-player game, but to others, they are like getting a single Tootsie Roll on Halloween. [Shane] of Stuff Made Here must fall into the latter category because he spent the equivalent of 18 work-weeks to make a robot that solves them automatically. Shots have been fired in the war on puzzles.

The goal of this robot is to beat a hybrid idea of two devilish puzzles. The first is all-white which could be solved by taking a piece at random and then checking its compatibility with every unsolved piece. The second is a 5000-piece monster painted white. There is a Moby Dick theme here. Picking up pieces like a human with fingers is out of the question, but pick-and-place machines solved this long ago, and we learn a cool lesson about how shop-air can create negative pressure. Suction. We wonder if anyone ever repurposed canned air to create a vacuum cleaner.

The meat of this video is overcoming hurdles, like a rhomboidal gantry table, helping machine vision see puzzle pieces accurately, and solving a small puzzle. [Shane] explains the solutions with the ear of someone with a technical background but at a high enough level that anyone can learn something. All the moving parts are in place, but the processing power to decode the puzzle is orders of magnitude higher than consumer machines, so that will wait for part two.

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Brass Plaque Honors Brother

Brass plaques are eye-catching because no one makes them on a whim. They are more costly than wood or plastic, and processing them is proportionally difficult. [Becky Stern] picked the medium to honor her brother, who enjoyed coffee, motorcycles, and making things by hand. She made some playing card-sized pieces to adorn his favorite brand of hot bean juice and a large one to hang at his memorial site.

The primary components are a vertical salt water bath, DC power supply, metal to etch, scrap steel approximately the same size, and a water agitator, which in this case is an air pump and diffuser stone. You could stir manually for two hours and binge your shows but trust us and take the easy route. The video doesn’t explicitly call for flexible wires, but [Becky] wisely selected some high-strand hook-up leads, which will cause fewer headaches as stiff copper has a mind of its own, and you don’t want the two sides colliding.

There are a couple of ways to transfer an insulating mask to metal, and we see the ole’ magazine paper method fail in the video, but cutting vinyl works a treat. You may prefer lasers or resin printers, and that’s all right too. Once your mask is sorted, connect the positive lead to the brass and the negative to your steel. Now, it’s into the agitated salt water bath, apply direct current, and allow electricity to immortalize your design.

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