The Blood Factory: New Research May Open The Door To Artificial Blood

There were news stories afoot this week with somewhat breathless headlines that suggested a medical breakthrough was at hand: “In a 1st, two people receive transfusions of lab-grown blood cells.” A headline like that certainly catches the eye, especially as the holidays approach and the inevitable calls for increased blood donations that always seem to happen this time of year as the supply gets pinched. Does a headline like that mean that someone is working on completely artificial blood?

As always with this sort of thing, the answer is a mixed bag. Yes, a team in the UK has transfused two patients with a small amount of lab-grown red blood cells, and it’s the first time that particular procedure has been performed. But while the headline is technically correct, the amount transfused was very small, so the day when lab-grown whole blood transfusions replace donated blood isn’t exactly here yet. But the details of what was done and why it was attempted are the really interesting part here, and it’s worth a deep dive because it does potentially point the way to a future where totally synthetic blood may be a real thing.

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On Getting A Computer’s Attention And Striking Up A Conversation

With the rise in voice-driven virtual assistants over the years, the sight of people talking to various electrical devices in public and in private has become rather commonplace. While such voice-driven interfaces are decidedly useful for a range of situations, they also come with complications. One of these are the trigger phrases or wake words that voice assistants listen to when in standby. Much like in Star Trek, where uttering ‘Computer’ would get the computer’s attention, so do we have our ‘Siri’, ‘Cortana’ and a range of custom trigger phrases that enable the voice interface.

Unlike in Star Trek, however, our virtual assistants do not know when we really desire to interact. Unable to distinguish context, they’ll happily respond to someone on TV mentioning their trigger phrase. This possibly followed by a ludicrous purchase order or other mischief. The realization here is the complexity of voice-based interfaces, while still lacking any sense of self-awareness or intelligence.

Another issue is that the process of voice recognition itself is very resource-intensive, which limits the amount of processing that can be performed on the local device. This usually leads to the voice assistants like Siri, Alexa, Cortana and others processing recorded voices in a data center, with obvious privacy implications.

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The Importance Of Physical Models: How Not To Shoot Yourself In The Foot Or Anywhere Else

We take shortcuts all the time with our physical models. We rarely consider that wire has any resistance, for example, or that batteries have a source impedance. That’s fine up until the point that it isn’t. Take the case of the Navy’s Grumman F11F Tiger aircraft. The supersonic aircraft was impressive, although it suffered from some fatal flaws. But it also has the distinction of being the first plane ever to shoot itself down.

So here’s the simple math. A plane traveling Mach 1 is moving about 1,200 km/h — the exact number depends on a few things like your altitude and the humidity. Let’s say about 333 m/s. Bullets from a 20 mm gun, on the other hand, move at more than 1000 m/second. So when the bullet leaves the plane it would take the plane over three seconds to catch up with it, by which time it has moved ever further away, right?

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Chinese Chips Are Being Artificially Slowed To Dodge US Export Regulations

Once upon a time, countries protected their domestic industries with tariffs on imports. This gave the home side a price advantage over companies operating overseas, but the practice has somewhat fallen out of fashion in the past few decades.

These days, governments are altogether more creative, using fancy export controls to protect their interests. To that end, the United States enacted an export restriction on high-powered computing devices. In response, Chinese designers are attempting to artificially slow their hardware to dodge these rules.

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The Wow! Signal Revisited: Citizen Science Informs SETI Effort

As far as interesting problems go, few can really compete with the perennial question: “Are we alone?” The need to know if there are other forms of intelligent life out there in the galaxy is deeply rooted, and knowing for sure either way would have massive implications.

But it’s a big galaxy, and knowing where to look for signals that might mean we’re not alone is a tough task. Devoting limited and expensive resources to randomly listen to chunks of the sky in the hopes of hearing something that’s obviously made by a technical civilization is unlikely to bear fruit. Much better would be to have something to base sensible observations on — some kind of target that has a better chance of paying off.

Luckily, a chance observation nearly 50 years ago has provided just that. The so-called Wow! Signal, much discussed but only occasionally and somewhat informally studied, has provided a guidepost in the sky, thanks in part to a citizen scientist with a passion for finding exoplanets.

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Dosimetry: Measuring Radiation

Thanks to stints as an X-ray technician in my early 20s followed by work in various biology labs into my early 40s, I’ve been classified as an “occupationally exposed worker” with regard to ionizing radiation for a lot of my life. And while the jobs I’ve done under that umbrella have been vastly different, they’ve all had some common ground. One is the required annual radiation safety training classes. Since the physics never changed and the regulations rarely did, these sessions would inevitably bore everyone to tears, which was a pity because it always felt like something I should be paying very close attention to, like the safety briefings flight attendants give but everyone ignores.

The other thing in common was the need to keep track of how much radiation my colleagues and I were exposed to. Aside from the obvious health and safety implications for us personally, there were legal and regulatory considerations for the various institutions involved, which explained the ritual of finding your name on a printout and signing off on the dose measured by your dosimeter for the month.

Dosimetry has come a long way since I was actively considered occupationally exposed, and even further from the times when very little was known about the effects of radiation on living tissue. What the early pioneers of radiochemistry learned about the dangers of exposure was hard-won indeed, but gave us the insights needed to develop dosimetric methods and tools that make working with radiation far safer than it ever was.

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M.2 For Hackers – Connectors

In the first M.2 article, I’ve described real-world types and usecases of M.2 devices, so that you don’t get confused when dealing with various cards and ports available out there. I’ve also designed quite a few M.2 cards and card-accepting adapters myself. And today, I’d like to tell you everything you need to know in order to build M.2 tech on your own.

There’s two sides to building with M.2 – adding M.2 sockets onto your PCBs, and building the PCBs that are M.2 cards. I’ll cover both of these, starting with the former, and knowing how to deal with M.2 sockets might be the only thing you ever need. Apart from what I’ll be describing, there’s some decent guides you can learn bits and pieces from, like the Sparkfun MicroMod design guide, most of which is MicroMod-specific but includes quite a few M.2 tips and tricks too.

First, Let’s Talk About The Y-Key

What could you do with a M.2 socket on your PCB? For a start, many tasty hobbyist-friendly SoMs and CPUs now have a PCIe interface accessible, and if you’re building a development board or a simple breakout, an M.2 socket will let you connect an NVMe SSD for all your high-speed low-power storage needs – many Raspberry Pi Compute Module mainboards have M.2 M-key sockets specifically for that, and there’s NVMe support in the RPi firmware to boot. Plus, you can always plug a full-sized PCIe adapter or an extender into such a socket and connect a PCIe network card or other much-needed device – even perhaps, an external GPU! However, as much as PCIe-equipped SoMs are tasty, they’re far from the only reason to use M.2 sockets.

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