Coronavirus Testing Follow-Up: Rapid Immunologic Testing

March 30, 2020 by Dan Maloney 12 Comments

When I started writing my recent article on COVID-19 testing, I assumed that I would be doing a compare and contrast sort of article. Like many people, I assumed that the “gold standard” test would be the reverse transcriptase-polymerase chain reaction (RT-PCR) test that I described in some detail. And indeed it is, but it’s not without its problems, such as the lack of certified labs and the need for trained technicians to run the samples. I also assumed there would be another test, a simple serological test that could use antibodies to discern if there was an active or even a previous, resolved infection.

At the time I wrote the first article, I could find no indication of an immunologic test for COVID-19 (more specifically, a test for SARS-Cov-2, the virus that causes COVID-19). But almost as rapidly as the number of COVID-19 cases rises, the news changes, and it appears that simple, rapidly performed antibody tests are now or soon will be available. They likely won’t replace the gold standard RT-PCR test, but they do stand to be a game-changer for the front line providers and the victims of this disease. So it pays to take a quick look at immunoassays for infectious diseases, and learn how they work.

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NIH Approved 3D-Printed Face Shield Design For Hospitals Running Out Of PPE

March 29, 2020 by Lewin Day 108 Comments

As the world faces a pandemic of monumental proportions, hospitals have been hit hard. The dual problems of disrupted manufacturing and supply chains and huge spikes in demand have led to many medical centres running out of protective gear. Makers have stepped up to help in many ways by producing equipment, with varying results. [Packy] has shared a link to a 3D-printable face shield that, unlike some designs floating around, is actually approved by the National Institute of Health in the USA.

The shield consists of a 3D printed headband, which is then coupled with a transparent piece of plastic for the face shield itself. This can be lasercut, or sourced from a document cover or transparency sheet. The design is printable in PLA or a variety of other common materials, and can be assembled easily with office supplies where necessary.

The design is available from the NIH here. (Update: 4/1/2020 here’s an alternate link as original link seems to be suffering from heavy server load) For those eager to help out, it’s important to do so in an organised fashion that doesn’t unduly take resources away from healthcare professionals trying to get an important job done. We’ve seen other hacks too, such as these 3D printed ventilator components being rushed into service in Italy.

Phantom Express: The Spaceplane That Never Was

March 27, 2020 by Tom Nardi 12 Comments

Even for those of us who follow space news closely, there’s a lot to keep track of these days. Private companies are competing to develop new human-rated spacecraft and assembling satellite mega-constellations, while NASA is working towards a return the Moon and the first flight of the SLS. Between new announcements, updates to existing missions, and literal rocket launches, things are happening on a nearly daily basis. It’s fair to say we haven’t seen this level of activity since the Space Race of the 1960s.

With so much going on, it’s no surprise that not many people have heard of the XS-1 Phantom Express. A project by the United States Defense Advanced Research Projects Agency (DARPA), the XS-1 was designed to be a reusable launch system that could put small payloads into orbit on short notice. Once its mission was complete, the vehicle was to return to the launch site and be ready for re-flight in as a little as 24 hours.

Alternately referred to as the “DARPA Experimental Spaceplane”, the vehicle was envisioned as being roughly the size of a business jet and capable of carrying a payload of up to 2,300 kilograms (5,000 pounds). It would take off vertically under rocket power and then glide back to Earth at the end of the mission to make a conventional runway landing. At $5 million per flight, its operating costs would be comparable with even the most aggressively priced commercial launch providers; but with the added bonus of not having to involve a third party in military and reconnaissance missions which would almost certainly be classified in nature.

Or at least, that was the idea. Flight tests were originally scheduled to begin this year, but earlier this year prime contractor Boeing abruptly dropped out of the program. Despite six years in development and over $140 million in funding awarded by DARPA, it’s now all but certain that the XS-1 Phantom Express will never get off the ground. Which is a shame, as even in a market full of innovative launch vehicles, this unique spacecraft offered some compelling advantages.

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Geofence Warrant Sends Bicyclist’s Privacy Over The Handlebars

March 25, 2020 by Kristina Panos 98 Comments

About a year ago, Zachary McCoy took a bike ride around his neighborhood in Gainesville, Florida. It may have been forgettable to him, but not to history. Because McCoy used an app to track his mileage, the route was forever etched in the Google-verse and attached to his name.

On the day of this ill-fated bike ride, McCoy passed a certain neighbor’s house three times. While this normally wouldn’t raise alarm, the neighbor happened to be the victim of a burglary that day, and had thousands of dollars worth of jewelry stolen. The Gainesville police had zero leads after a four-day investigation, so they went to the county to get a geofence warrant. Thanks to all the location data McCoy had willingly generated, he became the prime suspect.

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Ventilators 101: What They Do And How They Work

March 25, 2020 by Bob Baddeley 88 Comments

Treating the most serious cases of COVID-19 calls for the use of ventilators. We’ve all heard this, and also that there is a shortage of these devices. But there is not one single type of ventilator, and that type of machine is not the only option when it comes to assisted breathing being used in treatment. Information is power and having better grasp on this topic will help us all better understand the situation.

We recently wrote about a Facebook group focused on open source ventilators and other technology that could assist in the COVID-19 pandemic. There was an outpouring of support, and while the community is great when it comes to building things, it’s clear we all need more information about the problems doctors are currently dealing with, and how existing equipment was designed to address them.

It’s a long and complicated topic, though, so go get what’s left of your quarantine snacks and let’s dig in.

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Wind Farms In The Night: On-Demand Warning Lights Are Coming

March 24, 2020 by Sven Gregori 117 Comments

There appears to be no shortage of reasons to hate on wind farms. That’s especially the case if you live close by one, and as studies have shown, their general acceptance indeed grows with their distance. Whatever your favorite flavor of renewable energy might be, that’s at least something it has in common with nuclear or fossil power plants: not in my back yard. The difference is of course that it requires a lot more wind turbines to achieve the same output, therefore affecting a lot more back yards in total — in constantly increasing numbers globally.

Personally, as someone who encounters them occasionally from the distance, I find wind turbines mostly to be an eyesore, particularly in scenic mountainous landscapes. They can add a futuristic vibe to some otherwise boring flatlands. In other words, I can not judge the claims actual residents have on their impact on humans or the environment. So let’s leave opinions and emotions out of it and look at the facts and tech of one issue in particular: light pollution.

This might not be the first issue that comes to mind when thinking about wind farms. But wind turbines are tall enough to require warning lights for air traffic safety, and can be seen for miles, blinking away in the night sky. From a pure efficiency standpoint, this doesn’t seem reasonable, considering how often an aircraft is actually passing by on average. Most of the time, those lights simply blink for nothing, lighting up the countryside. Can we change this?

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Coronavirus Testing: Just The Facts

March 24, 2020 by Dan Maloney 42 Comments

The news these days is dominated by the one big story: the COVID-19 pandemic. Since the first reports of infection surfaced in China sometime in late 2019, the novel coronavirus that causes the disease, bloodlessly dubbed SARS-CoV-19, has swept around the globe destroying lives, livelihoods, and economies. Getting a handle on the disease has required drastic actions by governments and sacrifices by citizens as we try to slow the rate of infection

As with all infectious diseases, getting ahead of COVID-19 is a numbers game. To fight the spread of the virus, we need to know who has it, where they are, where they’ve been, and whom they’ve had contact with. If we are unable to gather the information needed to isolate potential carriers, all that we can do is impose mass quarantines and hope for the best. Hence the need for mass COVID-19 testing, and the understandable hue and cry about its slow pace and the limited availability of test kits.

But what exactly do these test kits contain? What makes mass testing so difficult to implement? As we shall see, COVID-19 testing is anything but simple, even if the underlying technology, PCR, is well-understood and readily available. A lot of the bottlenecks are, as usual, bureaucratic, but there are technical limits too. Luckily, there are clever ways around those restrictions, but understanding the basics of COVID-19 testing is the best place to start.

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