Reversing Type 1 Diabetes With A Patient’s Own Stem Cells

October 6, 2024 by Maya Posch 8 Comments

Type 1 diabetes is an auto-immune condition whereby the patient’s own immune system attacks the pancreatic islets, destroying them in the process. Since these islets are responsible for producing insulin in response to blood sugar (glucose) levels, the patient is thus required to externally inject insulin for the remainder of their life. That was the expected scenario, but it appears that this form of diabetes may soon be treatable, with one woman now being free of the condition for a year already, as reported in Nature, referencing an article by [Shusen Wang] et al. that describes the treatment and the one-year result.

Most notable with this study is that the researchers didn’t use the regular method to create pluripotent stem cells. These cells were extracted from the patient, to revert back to this earlier developmental stage. They were not modified using genes, but rather singular chemicals (PDF). The advantage of this is that it avoids having to modify the cell’s genomes, which could conceivably cause issues like cancer later on. This was one of the first time that this method was used in a human subject, with islet cells formed and about 1.5 million of them injected into the patient’s abdominal muscles, a novel site for this procedure.

This location made these islets easy to keep track of, and easier to remove in case of any issues compared to the usual injection site within the liver. Fortunately for this woman, no complications occurred and one year later she is still free of any diabetes symptoms. Two other patients in the trial are also seeing very positive results, leaving only the question of whether the auto-immune condition that originally caused the islet destruction still exists. Since this female patient is taking immunosuppressants for a previous liver transplant it’s a hard to thing to judge, especially since we understand the causes behind type 1 diabetes so poorly.

Regardless, this and other trials using pluripotent cells, transplanted islets and more offer the prospect of a permanent treatment for the many people who suffer from type 1 diabetes.

Featured image: “Human induced pluripotent stem cell colony” National Eye Institute/NIH

Hackaday Links: October 6, 2024

October 6, 2024 by Dan Maloney 22 Comments

Remember that time a giant cylindrical aquarium in a Berlin hotel bar catastrophically failed and left thousands of fish homeless? We sure do, and further recall that at the time, we were very curious about the engineering details of how this structure failed so spectacularly. At the time, we were sure there’d be plenty of follow-up on that score, but life happened and we forgot all about the story. Luckily, a faithful reader named Craig didn’t, and he helpfully ran down a few follow-up articles that came out last year that are worth looking at.

The first is from prosecutors in Berlin with a report offering three possibilities: that the adhesive holding together the acrylic panels of the aquarium failed; that the base of the tank was dented during recent refurbishment; or that the aquarium was refilled too soon after the repairs, leading to the acrylic panels drying out. We’re a little confused by that last one just from an intuitive standpoint, but each of these possibilities seems hand-wavy enough that the report’s executive summary could have been “Meh, Scheiße happens.”

Continue reading “Hackaday Links: October 6, 2024” →

Tinkering With Klipper: Making The ManiPilator Robotic Arm

October 6, 2024 by Heidi Ulrich 15 Comments

[Leo Goldstien]’s entry into the world of robotics has been full of stops and starts. Like many beginners, he found traditional robotics instructions overwhelming and hard to follow, bogged down with dense math that often obscured the bigger picture. So he decided to approach things differently and create something with his own hands. The result? A 3D-printed robotic arm he affectionately calls “ManiPilator.”

This article is the first in a three-part series documenting [Leo]’s hands-on approach to learning robotics from the ground up. Building ManiPilator became an opportunity to learn by doing, and the project took him on a journey of experimenting, failing, and eventually succeeding in tasks that seemed deceptively simple at first glance. Each hurdle provided him with insights that more traditional learning methods hadn’t delivered. Below is one of the videos [Leo] captured, to show one step in the process: doing a check using multiple motors.

To make his project work, [Leo] relied on open-source software like Klipper, piecing together code and hardware in a way that made sense to him. In sharing his story, he offers fellow beginners an approachable perspective on robotics, with practical insights and candid reflections on the challenges and breakthroughs.

[Leo]’s project shows that there’s more than one way to start exploring robotics, and that sometimes the best way to learn is simply to dive in and start building. Follow along with his journey as he tackles the complexities of robotics, one step at a time.

Continue reading “Tinkering With Klipper: Making The ManiPilator Robotic Arm” →

Tearing Down A Digital Scope From ’78

October 6, 2024 by Heidi Ulrich 5 Comments

If you’re a fan of vintage electronics and DIY tinkering, you’ll find this teardown by [Thomas Scherrer] fascinating. In a recent video, he delves into a rare piece of equipment: the Data Lab Transient Recorder DL 901. This device looks like a classic one-channel oscilloscope, complete with all the knobs and settings you’d expect.

The DL 901, made by Data Laboratories Ltd., is a mystery even to [Thomas], who couldn’t find any documentation online. From the DC offset and trigger settings to the sweep time controls, the DL 901 is equipped to handle slow, high-resolution analog-to-digital conversion. The circuitry includes TTL chips and a PMI DAAC 100, a 10-bit digital-to-analog converter. [Thomas] speculates it uses a successive approximation technique for analog-to-digital conversion—a perfect blend of analog finesse and digital processing for its time.

Despite its intriguing features, the DL 901 suffers from a non-responsive analog input system, limiting the teardown to a partial exploration. For those who enjoyed past Hackaday articles on oscilloscope teardowns and analog tech, this one is a treat. Watch the video to see more details and the full process of uncovering this vintage device’s secrets.

Continue reading “Tearing Down A Digital Scope From ’78” →

3D Printed Hydrofoil Goes From Model Scale To Human Scale With Flight Controller

October 6, 2024 by Danie Conradie 5 Comments

Hydrofoils have been around for several decades, but watching a craft slice through the water with almost no wake never get old. In the videos after the break, [rctestflight] showcases his ambitious project: transforming a standup paddleboard into a rideable hydrofoil with active stabilization.

Unlike conventional electric hydrofoil boards that depend on rider skill for balance, [rctestflight] aims to create a self-stabilizing system. He began by designing a small-scale model, complete with servo-controlled ailerons and elevators, dual motors for differential thrust, and a dRehmFlight flight controller. A pair of sonar sensors help the flight controller maintain constant height above the water. The wings are completely 3D printed, with integrated hinges for flight control surfaces slots for wiring and control components. It’s better suited for 3D printing than RC aircraft since it’s significantly less sensitive to weight, allowing for more structural reinforcement. The small scale tests were very successful and allowed [rctestflight] to determine that he didn’t need the vertical stabilizer and rudder.

The full-sized version features a scaled up wing, larger servos and motors attached to an 11-foot standup paddleboard — minus its rear end — mounted on commercially available e-foil booms. A foam battery box stores a hefty LiFePO4 battery, while the electronics from the smaller version are repurposed here. Despite only catching glimpses of this larger setup in action at the end of the video, it promises an excitingly smooth lake ride we would certainly like to experience.

We’ve seen several 3D printed hydrofoils around here, but this promised to be the largest successful attempt. Don’t fail us [Daniel].

Continue reading “3D Printed Hydrofoil Goes From Model Scale To Human Scale With Flight Controller” →

2View: The Self-Erasing VHS Tape With Paperclip Hack

October 6, 2024 by Maya Posch 17 Comments

The back of the 2View VHS box. The instructions are all in Dutch, as its (sole) launch market. (Credit: Techmoan, YouTube)

Over the decades the video and music industries have tried a wide range of ways to get consumers to buy ‘cheaper’ versions of albums and music, but then limit the playback in some way. Perhaps one of the most fascinating ones is the 2View, as recently featured by [Matt] over at Techmoan on Youtube. This is a VHS tape which works in standard VHS players and offers you all the goodness that VHS offers, like up to 512 lines of PAL video and hard-coded ads and subtitles, but also is restricted to just playing twice. After this second playback and rewinding, the tape self-erases and is blank, leaving you with just an empty VHS tape you can use for your own recordings.

As a form of analog restrictions management (ARM) it’s pretty simple in how it works, with [Matt] taking the now thankfully erased Coyote Ugly tape apart for a demonstration of the inside mechanism. This consists out of effectively just two parts: one plastic, spring-loaded shape that moves against one of the tape spools and follows the amount of tape, meaning minutes watched, and a second arm featuring a permanent magnet that is retained by an inner track inside the first shape until after rewinding twice it is released and ends up against the second spool, erasing the tape until rewound, after which it catches in a neutral position. This then left an erased tape that could be safely recorded on again.

Although cheaper than a comparable VHS tape without this limit, 2View was released in 2001, when in the Netherlands and elsewhere DVDs were demolishing the VHS market. This, combined with the fact that a simple bent paperclip could be stuck inside to retain the erase arm in place to make it a regular VHS tape, meant that it was really a desperate attempt that quickly vanished off the market

Continue reading “2View: The Self-Erasing VHS Tape With Paperclip Hack” →

Automated Pixel Art With Marbles

October 6, 2024 by Danie Conradie 11 Comments

Marble machines are a fun and challenging reason to do engineering for the sake of engineering. [Engineezy] adds some color to the theme, building a machine to create 16×16 marble images automatically. (Video embedded below.)

The core problem was devising ways to sort, lift, place, and dump marbles in their correct positions without losing their marbles—figuratively and literally. Starting with color detection, [Engineezy] used an RGB color sensor and Euclidian math to determine each marble’s color. After trying several different mechanical sorting mechanisms, he settled on a solenoid and servo-actuated dump tube to drop the marble into the appropriate hopper.

After sorting, he faced challenges with designing a mechanism to transport marbles from the bottom hoppers to the top of the machine. While paddle wheels seemed promising at first, they tended to jam—a problem solved by innovating with Archimedes screws that move marbles up smoothly without clogs. The marbles are pushed into clear tubes on either side of the machine, providing a clear view of their parade to the top.

Perhaps most ingenious is his use of constant-force springs as a flexible funnel to guide the marbles to a moving slider that drops them into the correct column of the display. When a picture is complete, sliding doors open on the bottom of the columns, dumping the marbles into a chain lift which feeds them into the sorting section. Each of the mechanisms has a mirrored version of the other side, so the left and right halves of the display operate independently.

The final product is slow, satisfying and noisy kinetic testament to [Engineezy]’s perseverance through countless iterations and hiccups.

Marble machines can range from minimalist to ultra-complex musical monstrosities, but never fail to tickle our engineering minds. Continue reading “Automated Pixel Art With Marbles” →