Decellularization: Apples To Earlobes

April 30, 2018 by Brian McEvoy 40 Comments

Our bodies are not like LEGO blocks or computers because we cannot swap out our parts in the living room while watching television. Organ transplants and cosmetic surgery are currently our options for upgrades, repairs, and augments, but post-transplant therapy can be a lifelong commitment because of rejection. Elective surgery costs more than a NIB Millenium Falcon LEGO set. Laboratories have been improving the processes and associated treatments for decades but experimental labs and even home laboratories are getting in on the action as some creative minds take the stage. These folks aren’t performing surgeries, but they are expanding what is possible to for people to do and learn without a medical license.

One promising gateway to human building blocks is the decellularization and recellularization of organic material. Commercial scaffolds exist but they are expensive, so the average tinkerer isn’t going to be buying a few to play with over a holiday weekend.

Let’s explore what all this means. When something is decellularized, it means that the cells are removed, but the structure holding the cells in place remains. Recellularizing is the process where new cells are grown in that area. Decellularizing is like stripping a Hilton hotel down to the girders. The remaining structures are the ECM or the Extra Cellular Matrix, usually referred to as scaffolding. The structure has a shape but no functionality, like a stripped hotel. The scaffolding can be repopulated with new cells in the same way that our gutted hotel can be rebuilt as a factory, office building, or a hospital.

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An Open Source Sip-and-Puff Mouse For Affordable Accessibility

April 27, 2018 by Dan Maloney 22 Comments

At the core of any assistive technology is finding a way to do something with whatever abilities the user has available. This can be especially difficult in the case of quadriplegia sufferers, the loss of control of upper and lower limbs caused by spinal cord damage in the cervical region. Quadriplegics can gain some control of their world with a “Sip-and-puff” device, which give the user control via blowing or sucking on a mouthpiece.

A sip-and-puff can make a world of difference to a quadriplegic, but they’re not exactly cheap. So to help out a friend, [Jfieldcap] designed and built an open source sip-and-puff mouse on the cheap. As is best for such devices, the design is simple and robust. The hollow 3D-printed mouthpiece acts as handle for a joystick module , and a length of tubing connects the mouthpiece to a pressure sensor. An Arduino lets the user move his head to position the cursor; hard sips and puffs are interpreted as left and right clicks, while soft mouth pressure is used for scrolling. In conjunction with some of the accessibility tools in modern OSes and personal assistant software like Siri or Cortana, the sip-and-puff opens up the online world, and for all of $50 in material.

We’re impressed by the effort and the results, but we worry that the standard PLA used for the mouthpiece won’t stand up to the cleaning it’ll need. Of course, printing extra mouthpieces is easy, but since it’s going to be in contact with the mouth, perhaps a review of food-safe 3D-printing is in order.

AlterEgo Listens To Your Internal Voice

April 12, 2018 by Al Williams 27 Comments

Recent news reports have claimed that an MIT headset can read your mind, but as it turns out that’s a little bit of fake news. There is a headset — called AlterEgo — but it doesn’t actually read your mind. Rather, it measures subtle cues of you silently vocalizing words. We aren’t sure exactly how that works, but the FAQ claims it is similar to how you experience reading as a child.

If you read much science fiction, you probably recognize this as subvocalization, which has been under study by the Army and NASA. However, from what we know, the positioning of sensor electrodes is crucial and can vary not only by speaker, but also change for the same speaker. Perhaps the MIT device has found a way around that problem. You can see a video of the system, below.

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Assess Your Output With A Cheap DIY Urine Flowmeter

April 1, 2018 by Dan Maloney 35 Comments

Some things about the human body are trivial to measure. Height, weight, blood pressure, pulse, temperature — these are all easily quantifiable with the simplest of instruments and can provide valuable insights into our state of health. Electrical activity in the heart and the brain can be captured with more complex instruments, too, and all manner of scopes can be inserted into various orifices to obtain actionable information about what’s going on.

But what about, err, going? Urine flow can be an important leading indicator for a host of diseases and conditions, but it generally relies on subjective reports from the patient. Is there a way to objectively measure how well urine is flowing? Of course there is.

The goal for [GreenEyedExplorer]’s simple uroflowmeter is simple: provide a cheap, easy to use instrument that any patient can use to quantify the rate of urine flow while voiding. Now, we know what you’re thinking — isn’t liquid flow usually measured in a closed system with a paddlewheel or something extending into the stream? Wouldn’t such a device for urine flow either be invasive or messy, or both? Rest assured, this technique is simple and tidy. A small load cell is attached to an ESP8266 through an HX711 load cell amp. A small pan on the load cell receives urine while voiding, and the force of the urine striking the pan is assessed by the software. Reports can be printed to share with your doctor, and records are kept to see how flow changes over time.

All kidding aside, this could be an important diagnostic tool, and at 10€ to build, it empowers anyone to take charge of their health. And since [GreenEyedExplorer] is actually a urologist, we’re taking this one seriously.

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The IoT (Internet Of Teeth)

April 1, 2018 by Christopher Wang 22 Comments

Get ready for another step towards our dystopian future as scientists have invented a way to track and monitor what we eat. This 2mm x 2mm wireless sensor can be mounted on to teeth and can track everything that goes into your mouth. Currently it can monitor salt, glucose, and alcohol intake. The sensor then communicates wirelessly to a mobile device that tracks the data. Future revisions are predicted to monitor a wide range of nutrients and chemicals that can get ingested.

It uses an interesting method to both sense the target chemicals and communicate its data. It consists of a sandwich of three layers with the central layer being a biosensor that reacts to certain chemicals. The complete sandwich forms a tiny RFID antenna and when RF signals are transmitted to the device, some of the signal gets absorbed by the antenna and the rest reflected back.

The mechanism is similar to how chromatography works for chemical analysis where certain chemicals absorb light wavelengths of specific frequencies. Passing a calibrated light source through a gas column and observing the parts of the spectrum that get absorbed allows researchers to identify certain chemicals inside the column.

This technology is based on previous research with”tooth tatoos” that could be used by dentists to monitor your oral health. Now this tiny wireless sensor has evolved to monitoring the dietary intake of people for health purposes but we’re pretty sure Facebook is eyeing it for more nefarious purposes too.

3D Printed Stethoscope Makes The Grade

March 17, 2018 by Tom Nardi 22 Comments

On the off chance that initiatives like the Hackaday Prize didn’t make it abundantly clear, we believe strongly that open designs can change the world. Putting technology into the hands of the people is a very powerful thing, and depending on where you are or your station in life, can quite literally mean the difference between life and death. So when we saw that not only had a team of researchers developed a 3D printable stethoscope, but released everything as open source on GitHub, it’s fair to say we were pretty interested.

The stethoscope has been in development for several years now, but has just recently completed a round of testing that clinically validated its performance against premium brand models. Not only does this 3D printed stethoscope work, it works well: tests showed its acoustic performance to be on par with the gold standard in medical stethoscopes, the Littmann Cardiology III. Not bad for something the researchers estimate can be manufactured for as little as $3 each.

All of the 3D printed parts were designed in OpenSCAD (in addition to a Ruby framework called CrystalSCAD), which means the design can be evaluated, modified, and compiled into STLs with completely free and open source tools. A huge advantage for underfunded institutions, and in many ways the benchmark by which other open source 3D-printable projects should be measured. As for the non-printed parts, there’s a complete Bill of Materials which even includes links to where you can purchase each item.

The documentation for the project is also exceptional. It not only breaks down exactly how to print and assemble the stethoscope, it even includes multi-lingual instructions which can be printed out and distributed with kits so they can be assembled in the field by those who need them most.

From low-cost ultrasounds to truly personalized prosthetics, the future of open source medical devices is looking exceptionally bright.

[Thanks to Qes for the tip]

Reverse Engineer An X-Ray Image Sensor

March 15, 2018 by Jenny List 19 Comments

If you think of a medical x-ray, it is likely that you are imagining a photographic plate as its imaging device. Clipped to your tooth by your dentist perhaps, or one of the infamous pictures of the hands of [Thomas Edison]’s assistant [Clarence Madison Dally].

As with the rest of photography, the science of x-ray imaging has benefited from digital technology, and it is now well established that your hospital x-ray is likely to be captured by an electronic imaging device. Indeed these have now been in use for so long that their first generation can even be bought by an experimenter for an affordable sum, and that is what the ever-resourceful [Lucy Fauth] with the assistance of [Jana Marie Hemsing], has done. Their Trophy DigiPan digital x-ray image sensor was theirs for around a hundred Euros, and though it’s outdated in medical terms it still has huge potential for the x-ray experimenter.

The write-up is a fascinating journey into the mechanics of an x-ray sensor, with the explanation of how earlier devices such as this one are in fact linear CCD sensors which track across the exposed area behind a scintillator layer in a similar fashion to the optical sensor in a flatbed scanner. The interface is revealed as an RS422 serial port, and the device is discovered to be a standalone unit that does not require any commands to start scanning. On power-up it sends a greyscale image, and a bit of Sigrok examination of the non-standard serial stream was able to reveal it as 12-bit data direct from the sensor. From those beginnings they progressed to an FPGA-based data processor and topped it all off with a very tidy power supply in a laser-cut box.

It’s appreciated that x-rays are a particularly hazardous medium to experiment with, and we note from their videos that they are using some form of shielding. The source is a handheld fluoroscope of the type used in sports medicine that produces a narrow beam. If you remember the discovery of an unexpected GameBoy you will be aware that medical electronics seems to be something of a speciality in those quarters, as do autonomous box carriers.

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