biology

80 Articles

Gentle Electric Eel

May 16, 2018 by 22 Comments

It’s no shock that electric eels get a bad rap for being scary creatures. They are slithery fleshy water snakes who can call down lightning. Biologists and engineers at the University of California had something else in mind when they designed their electric eel. Instead of hunting fish, this one swims harmlessly alongside them.

Traditional remotely operated vehicles have relied on hard shells and spinning propellers. To marine life, this is noisy and unnatural. A silent swimmer doesn’t raise any eyebrows, not that fish have eyebrows. The most innovative feature is the artificial muscles, and although the details are scarce, they seem to use a medium on the inside to conduct a charge, and on the outside, the saltwater environment conducts an opposite charge which causes a contraction in the membrane between to the inside and outside. Some swimming action can be seen below the break, and maybe one of our astute readers can shed some light on this underwater adventurer’s bill of materials.

One of our favorite submarines is the 2017 Hackaday Prize winner, The Open Source Underwater Glider. For a more artistic twist on submersibles, the Curv II is one of the most elegant we have seen.

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Carbon Augmented Spider Silk

March 15, 2018 by 22 Comments

Some of the creepy-crawlers under our feet, flitting through the air, and waiting on silk webs, incorporate metals into their rigid body parts and make themselves harder. Like Mega Man, they absorb the metals to improve themselves. In addition to making their bodies harder, silk-producing creatures like worms and spiders can spin webs with augmented properties. These silks can be conductive, insulating, or stronger depending on the doping elements.

At Italy’s University of Trento, they are pushing the limits and dosing spiders with single-wall carbon nanotubes and graphene. The carbon is suspended in water and sprayed into the spider’s habitat. After the treatment, the silk is measured, and in some cases, the silk is significantly tougher and surpasses all the naturally occurring fibers.

Commercial spider silk harvesting hasn’t been successful, so maybe the next billionaire is reading this right now. Let’s not make aircraft-grade aluminum mosquitoes though. In fact, here’s a simple hack to ground mosquitoes permanently. If you prefer your insects alive, maybe you also like their sound.

Thank you for the tip, [gippgig].

Henrietta Lacks And Immortal Cell Lines

January 9, 2018 by 80 Comments

In early 1951, a woman named Henrietta Lacks visited the “colored ward” at Johns Hopkins hospital for a painful lump she found on her cervix. She was seen by Dr. Howard W. Jones, who indeed found a tumor growing on the surface of her cervix. He took a tissue sample, which confirmed Henrietta’s worst fears: She had cancer.

The treatment at the time was to irradiate the tumor with radium tubes placed in and around the cervix. The hope was that this would kill the cancerous cells while preserving the healthy tissue. Unbeknownst to Henrietta, a biopsy was taken during her radium procedure. Slivers of her tumor and of healthy cervix cells were cut away. The cancer cells were used as part of a research project. Then something amazing happened: the cancerous cells grew and continued to grow outside of her body.

As Henrietta herself lay dying, the HeLa immortal cell line was born. This cell line has been used in nearly every aspect of medical research since the polio vaccine. Millions owe their lives to it. Yet, Henrietta and her family never gave consent for any of this. Her family was not informed or compensated. In fact, until recently, they didn’t fully grasp exactly how Henrietta’s cells were being used.

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Automated Chamber Passes Just The Right Gas

November 15, 2017 by 2 Comments

It sounds like an overly complicated method a supervillain would use to slowly and painfully eliminate enemies — a chamber with variable oxygen concentration. This automated environmental chamber isn’t for torturing suave MI6 agents, though; rather, it enables cancer research more-or-less on the cheap.

Tasked with building something to let his lab simulate the variable oxygen microenvironments found in some kinds of tumors, [RyanM415] first chose a standard lab incubator as a chamber to mix room air with bottled nitrogen. With a requirement to quickly vary the oxygen concentration from the normal 21% down to zero, he found that the large incubator took far too long to equilibrate, and so he switched to a small acrylic box. Equipped with a mixing fan, the smaller chamber quickly adjusts to setpoints, with an oxygen sensor providing feedback and controlling the gas valves via a pair of Arduinos. It’s quite a contraption, with floating ball flowmeters and stepper-actuated variable gas valves, but the results are impressive. If it weren’t for the $2000 oxygen sensor, [RyanM145] would have brought the whole project in for $500, but at least the lab can use the sensor elsewhere.

Modern biology and chemistry labs are target-rich environments for hacked instrumentation. From DIY incubators to cheap electrophoresis rigs, we’ve got you covered.

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The Hackaday Prize: Growing Your Own Soil

October 7, 2017 by 15 Comments

When a rainforest is clearcut for agricultural use, we only see the surface problems: fewer trees, destruction of plant and animal habitats, and countless other negative effects on the environment. A lurking problem, however, is that the soil is often non-ideal for farming. When the soil is exhausted, the farmers move further into the rainforest and repeat the process.

In the Amazon, however, there are pockets of man-made soil that are incredibly nutrient-dense. Figuring out how to make this soil, known as Terra Preta, on a massive scale would limit the amount of forest destruction by providing farmers a soil with more longevity which will, in turn, limit the encroachment on the rainforest. That’s the goal of this Hackaday Prize entry by [Leonardo Zuniga]: a pyrolysis chemical reactor that can make this soil by turning organic matter into a type of charcoal that can be incorporated into the soil to make Terra Preta.

As a bonus to making this nutrient-dense soil on a massive scale, this reactor also generates usable energy as a byproduct of processing organic waste, which goes several steps beyond simple soil enrichment. If successful and scalable, this project could result in more efficient farming techniques, greater yields, and, best of all, less damage to the environment and less impact on the rainforests.

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Living Logic: Biological Circuits For The Electrically Minded

August 21, 2017 by 18 Comments

Did you know you can build fundamental circuits using biological methods? These aren’t your average circuits, but they work just like common electrical components. We talk alot about normal silicon and copper circuits ‘roud here, but it’s time to get our hands wet and see what we can do with the power of life!

In 1703, Gottfried Wilhelm Leibniz published his Explication de l’Arithmétique Binaire (translated). Inspired by the I Ching, an ancient Chinese classic, Leibniz established that the principles of arithmetic and logic could be combined and represented by just 1s and 0s. Two hundred years later in 1907, Lee De Forest’s “Audion” is used as an AND gate. Forty years later in 1947, Brattain and H. R. Moore demonstrate their “PNP point-contact germanium transistor” in Bell Labs (often given as the birth date of the transistor). Six years later in 1953, the world’s first transistor computer was created by the University of Manchester. Today, 13,086,801,423,016,741,282,5001 transistors have built a world of progressing connectivity, automation and analysis.

While we will never know how Fu Hsi, Leibniz, Forest or Moore felt as they lay the foundation of the digital world we know today, we’re not completely out of luck: we’re in the midst’s of our own growing revolution, but this one’s centered around biotechnology. In 1961, Jacob and Monod discovered the lac system: a biological analog to the PNP transistor presented in Bell Labs fourteen years earlier. In 2000, Gardner, Cantor, and Collins created a genetic toggle switch controlled by heat and a synthetic fluid bio-analog2. Today, AND, OR, NOR, NAND, and XOR gates (among others) have been successfully demonstrated in academic labs around the world.

But wait a moment. Revolution you say? Electrical transistors went from invention to computers in 6 years, and biological transistors went from invention to toggle button in 40? I’m going to get to the challenges facing biological circuits in time, but suffice it to say that working with living things that want to be fed and (seem to) like to die comes with its own set of challenges that aren’t relevant when working with inanimate and uncaring transistors. But, in the spirit of hacking, let’s dive right in. Continue reading “Living Logic: Biological Circuits For The Electrically Minded” →

Synthetic Biology Creates Living Computers

August 9, 2017 by 25 Comments

Most people have at least a fuzzy idea of what DNA is. Ask about RNA, though, and unless you are talking to a biologist, you are likely to get even more handwaving. We hackers might have to reread our biology text books, though, since researchers have built logic gates using RNA.

Sometimes we read these university press releases and realize that the result isn’t very practical. But in this case, the Arizona State University study shows how AND, OR, and NOT gates are possible and shows practical applications with four-input AND gates and six-input OR gates using living cells. The key is a construct known as an RNA toehold switch (see video below). Although this was worked out in 2012, this recent study shows how to apply it practically.

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