One of the big stories last week was the announcement of results from clinical trials that suggest a new COVID-19 vaccine developed through the joint effort of the American and German companies Pfizer and BioNTech is strongly effective in providing immunity from the virus. In the midst of what is for many countries the second spike of the global pandemic this news has been received with elation as well as becoming the subject of much political manoeuvring.
While we currently have two vaccine candidates with very positive testing results, one of the most interesting things for us is the need to keep doses of the Pfizer/BioNTech vaccine extremely cold until they are administered. Let’s dig into details of the refrigeration problem at hand.
Ask someone who isn’t technically inclined how a TV signal works or how a cell phone works, or even how a two-way switch in a hall light works and you are likely to get either a blank stare or a wildly improbable explanation. But there are some things so commonplace that even the most tech-savvy of us don’t bother thinking about. One of these things is the lowly gas pump.
Gas pumps are everywhere and it’s a safe bet to assume everyone reading this has used one at some point, most of use on a regular basis. But what’s really going on there?
Most of it is pretty easy to figure out. As the name implies, there must be a pump. There’s some way to tell how much is pumping and how much it costs and, today, some way to take the payment. But what about the automatic shut off? It isn’t done with some fancy electronics, that mechanism dates back decades. Plus, we’re talking about highly combustible materials, there has to be more to it then just a big tank of gas and a pump. Safety is paramount and, experientially, we don’t hear about gas stations blowing up two or three times a day, so there must be some pretty stout safety features. Let’s pay homage to those silent safety features and explore the tricks of the gasoline trade.
With the Mars 2020 mission now past the halfway point between Earth and its destination, NASA’s Jet Propulsion Lab recently released a couple of stories about the 3D-printed parts that made it aboard the Perseverance rover. Tucked into its aeroshell and ready for its high-stakes ride to the Martian surface, Perseverance sports eleven separate parts that we created with additive manufacturing. It’s not the first time a spacecraft has flown with parts made with additive manufacturing technique, but it is the first time JPL has created a vehicle with so many printed parts.
To take a closer look at what 3D-printing for spaceflight-qualified components looks like, and to probe a little into the rationale for additive versus traditional subtractive manufacturing techniques, I reached out to JPL and was put in touch with Andre Pate, Additive Manufacturing Group Lead, and Michael Schein, lead engineer on one of the mission’s main scientific instruments. They both graciously gave me time to ask questions and geek out on all the cool stuff going on at JPL in terms of additive manufacturing, and to find out what the future holds for 3D-printing and spaceflight.
The incandescent light bulb was one of the first early applications of electricity, and it’s hard to underestimate its importance. But before the electric light, people didn’t live in darkness — they thought of ways to redirect sunlight to brighten up interior spaces. This was made possible through the understanding of the basic principles of optics and the work of skilled glassmakers who constructed prism tiles, deck prisms, and vault lights. These century-old techniques are still being applied today for the diffusion of LEDs or for increasing the brightness of LCD displays.
Semantics First!
People in optics are a bit sloppy when it comes to the definition of a prism. While many of them are certainly not geometric prisms, Wikipedia defines it as a transparent optical element with flat, polished surfaces of which at least one is angled. As can be seen in the pictures below some of the prisms here do not even stick to this definition. Browsing the catalog of your favorite optics supplier you will find a large variety of prisms used to reflect, invert, rotate, disperse, steer, and collimate light. It is important to point out that we are not so much interested in dispersive prisms that split a beam of white light into its spectrum of colors, although they make great album covers. The important property of prisms in this article is their ability to redirect light through refraction and reflection.
A Safe Way to Bring Light Under Deck
A collection of deck lights used to direct sunlight below deck in ships. Credit: glassian.org
One of the most important uses of prism lighting was on board ships. Open flames could have disastrous consequences aboard a wooden ship, so deck prisms were installed as a means to direct sunlight into the areas below decks. One of the first patents for deck lights “THE GREAT AND DURABLE INCREASE OF LIGHT BY EXTRAORDINARY GLASSES AND LAMPS” was filed by Edward Wyndus as early as 1684. Deck prisms had typical sizes of 10 to 15 centimeters. The flat top was installed flush with the deck and the sunlight was refracted and directed downward from the prism point. Because of the reversibility of light paths (“If I can see you, you can see me”) deck prisms also helped to spot fires under deck. Continue reading “Prism Lighting – The Art Of Steering Daylight”→
As a debugger, GDB is a veritable Swiss Army knife. And just like exploring all of the non-obvious uses of a those knives, your initial response to the scope of GDB’s feature set is likely to be one of bewilderment, subsequent confusion, and occasional laughter. This is an understandable reaction in the case of the Swiss Army knife as one is unlikely to be in the midst of an army campaign or trapped in the wilderness. Similarly, it takes a tricky debugging session to really learn to appreciate GDB’s feature set.
If you have already used GDB to debug some code, it was likely wrapped in the comfort blanket of an IDE. This is of course one way to use GDB, but limits the available features to what the IDE exposes. Fortunately, the command line interface (CLI) of GDB has no such limitations. Learning the CLI GDB commands also has the advantage that one can perform that critical remote debug session even in the field via an SSH session over the 9600 baud satellite modem inside your Swiss Army knife, Cyber Edition.
Have I carried this analogy too far? Probably. But learning the full potential of GDB is well worth your time so today, let’s dive in to sharpen our digital toolsets.
It seems like just yesterday (maybe for some of you it was) we were installing Windows 3.1 off floppy drives onto a 256 MB hard drive, but hard drives have since gotten a lot bigger and a lot more complicated, and there are a lot more options than spinning platters.
The explosion of storage options is the result of addressing a variety of niches of use. The typical torrenter downloads a file, which is written once but read many times. For some people a drive is used as a backup that’s stored elsewhere and left unpowered. For others it is a server frequently reading and writing data like logs or swap files. In all cases it’s physics that sets the limits of what storage media can do; if you choose wisely for your use case you’ll get the bet performance.
The jargon in this realm is daunting: superparamagnetic limit, LMR, PMR, CMR, SMR, HAMR, MAMR, EAMR, XAMR, and QLC to name the most common. Let’s take a look at how we got here, and how the past and present of persistent storage have expanded what the word hard drive actually means and what is found under the hood.
It sounds like science fiction — and until 2012, the ability to cheaply and easily edit strings of DNA was exactly that. But as it turns out, CRISPR/Cas9 gene editing is a completely natural function in which bacteria catalogs its interactions with viruses by taking a snippet of the virus’ genetic material and filing it away for later.
Now, two women have won the 2020 Nobel Prize in Chemistry “for developing a method for genome editing”. Emmanuelle Charpentier and Jennifer Doudna leveraged CRISPR into a pair of genetic scissors and showed how sharp they are by proving that they can edit any string of DNA this way. Since Emmanuelle and Jennifer published their 2012 paper on CRISPR/Cas9, researchers have used these genetic scissors to create drought-resistant plants and look for new gene-based cancer therapies. Researchers are also hoping to use CRISPR/Cas9 to cure inherited diseases like Huntington’s and sickle cell anemia.
The discovery started with Emmanuelle Charpentier’s investigation of the Streptococcus pyogenes bacterium. She was trying to understand how its genes are regulated and was hoping to make an antibiotic. Once she teamed up with Jennifer Doudna, they found a scientific breakthrough instead.
Emmanuelle Charpentier was born December 11th, 1968 in Juvisy-sur-Orge, France. She studied biochemistry, microbiology, and genetics at the Pierre and Marie Curie University, which is now known as Sorbonne University. Then she received a research doctorate from Institut Pasteur and worked as a university teaching assistant and research scientist. Dr. Charpentier is currently a director at the Max Planck Institute for Infection Biology in Berlin, and in 2018, she founded an independent research unit.
Upon completion of her doctorate, Dr. Charpentier spent a few years working in the States before winding up at the University of Vienna where she started a research group. Her focus was still on the bacteria Streptococcus pyogenes, which causes millions of people to suffer through infections like tonsillitis and impetigo each year. It also causes sepsis, which officially makes it a flesh-eating bacterium.
