How Biohackers Are Fighting A Two-front War On Antibiotic Resistance

We humans like to think of ourselves as the pinnacle of evolution on the planet, but that’s just a conceit. It takes humans roughly twenty years to reproduce, whereas some bacteria can make copies of themselves every 20 minutes. Countless generations of bacteria have honed and perfected their genomes into extremely evolved biological machines.

Most bacteria are harmless, and some are quite useful, even tasty – witness the lactofermented pickles and sauerkraut I made this summer. But some bacteria are pathogenic nightmares that have swarmed over the planet and caused untold misery and billions of deaths. For most of human history it has been so – the bugs were winning. Then a bright period dawned in the early 20th century – the Era of Antibiotics. At last we were delivered from the threat of pestilence, never more to suffer from plague and disease like our unfortunate ancestors. Infections were miraculously cured with a simple injection or pill, childhood diseases were no longer reaping their tragic harvest, and soldiers on the battlefield were surviving wounds that would have festered and led to a slow, painful death.

Now it seems like this bright spot of relief from bacterial disease might be drawing to an end. Resistant strains of bacteria are in the news these days, and the rise of superbugs seems inevitable. But is it? Have we run out of tools to fight back? Not quite yet as it turns out. But there’s a lot of work to do to make sure we win this battle.

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The Rise Of The Rural Hacker

On the far side of the Boso peninsula lies Kamogawa. This isn’t the Japan of LEDs, Otaku and maid cafes, or that of wage slave salarymen collapsing from exhaustion. This is the Japan of rice farmers and fields, fresh fish and wild boar, electron microscopes and gigabit fiber, SMD assembly and 500Mhz 5 Gigasample oscilloscopes.

The world has changed. In the 20th century the life of a rural hacker was a constant hunt for technological innovation. We scratched around for whatever we could find. A (usually national) periodical would give its monthly injection of technological curios. And knowledge was locked tight within expensive textbooks, which even if you could afford them might take weeks to arrive.

So, as had been the case for the preceding 1000 years, innovation clustered around technological hubs, San Francisco, Cambridge, and Tokyo among others. And Hackers flocked to these centers where innovation flourished while Hackers exchanged knowledge and tools.

But then the world of the rural Hacker began to expand. The technological hubs that so many rural hackers had migrated to began to connect the world. Young Hackers could learn to program (as I learned C) from textfiles posted on BBSs and exchange knowledge linking national communities. Shortly after that the Internet came bringing its Eternal September. Hackers across the world, regardless of location could communicate.

On the flip-side tech centers were changing too. Venture capital, rather than bootstrapping became the norm. With the influx of cash the demand for skilled Hackers rose, increasing wages and further focusing tech talent around these hubs. But rents and expenses rose too. And Hackers became locked into their expensive lifestyles; eyes firmly focused on the promised million dollar payoff and the eternal dream of an “exit”.

For some though, the freedom to Hack is more important than that million dollar exit and so a new model is emerging. Groups of Hackers in rural communities with low cost lifestyles and access to the world’s best technical talent and equipment that would put the best startups to shame.

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Embed With Elliot: Practical State Machines

Raindrops on roses, and whiskers on kittens. They’re ok, but state machines are absolutely on our short list of favorite things.

There are probably as many ways to implement a state machine as there are programmers. These range from the terribly complex, one-size-fits-all frameworks down to simply writing a single switch...case block. The frameworks end up being a little bit of a black box, especially if you’re just starting out, while the switch...case versions are very easy to grok, but they don’t really help you write clear, structured code.

In this extra-long edition of Embed with Elliot, we’ll try to bridge the middle ground, demonstrating a couple of state machines with an emphasis on practical coding. We’ll work through a couple of examples of the different ways that they can be implemented in code. Along the way, we’ll Goldilocks solution for a particular application I had, controlling a popcorn popper that had been hacked into a coffee roaster. Hope you enjoy.

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How To Build Anything Using Delrin And A Laser Cutter

Need a simple fab process to go from a humble vector graphic to a final part — in a matter of minutes? The CO2  laser cutter might be the right choice. As these tools open themselves up to widespread use through hackerspaces, I decided to give Delrin some well-deserved time under the spotlight.

The laser cutter yet-again proves itself a formidable tool with the construction of GameCube-Bot V2

This guide is a brief collection of tips and techniques that I’ve either learned from others or discovered on my own over the last couple years working with laser-cut Delrin (a.k.a Acetal) for functional prototypes. I hope this guide serves you well as we keep exploring the limits of the material.

As a disclaimer, keep in mind that in no way are these techniques unique or limited to Delrin. Many are not only years old but also common practice in either engineering design or the local machine shop. This article simply highlights the techniques shown here that perform both repeatably and predictably with Delrin and a couple hand-tools, and I hope to share them with a growing audience of laser cutter enthusiasts.

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Learn 3D Modeling In Your Browser

If you have a 3D printer, it is a good bet you’ve at least seen or heard of Tinkercad. There’s pros and cons to doing your design in a Web browser, but Tinkercad is very easy to use and great for making simple objects. However, there are other 3D object designers you can use in your browser, too. Tinkercad is just the one that everyone seems to know about.

I won’t talk much about Tinkercad, but if you haven’t tried it, it is well worth a look. It has a simple system of drawing things and holes. When you merge holes with things you can make lots of shapes. The alignment tools are good, and since Autodesk acquired them (part of its 123d app suite), it isn’t likely they will go under any time soon (which, as you may remember, almost happened).

If you are designing some great new secret invention you may shy away from cloud-based design programs. But if you are printing out key chains with your coworker’s cat’s name on it, do you really care? Most of these cloud-based programs will work from any computer so you can quickly do a design in a coffee shop and then go home and print it.

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Why IoT Will Fail (and How To Save It)

Buzzword technology has two possible fates: they fail and disappear or they succeed and disappear. Remember at one time “multimedia” and “networking” were buzzwords. They succeeded and now they’ve vanished into ubiquity. Of course, there are plenty of failed buzzwords (like telecosm) that you probably don’t even remember. They just vanished into obscurity.

Unless you’ve been living under the CNC mill in your local hackerspace, you’ve probably heard or read about the “Internet of Things” (IoT). Companies big and small have realized that getting in early on The Next Big Thing is good for share prices and, right now, IoT is where everyone is trying to make a play.

There’s two things I’d observe, though: First, IoT is far from new. Connecting embedded systems to the Internet is old hat (I even wrote a book called Embedded Internet Design way back in 2003). Second, the way it is going, IoT–in its current incarnation–is doomed.

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How CMOS Works: Some Final Words About CMOS

Finishing up on the topic of CMOS bus logic I am going to show a couple of families with unique properties that may come in handy one day.

High Voltage Tolerant Family: AHC/AHCT

AHCT w/o high side diode
Note the missing diode to VDD

First up is a CMOS logic family  AHC/AHCT that has one of the protection diodes on the input removed.  This allows a 5V input voltage to be applied to a device powered by 3.3V so that I don’t have to add a gate just for the translation.  Any time I can translate and do it without any additional gate delays I am a happy engineer.

Of course the example above works in a single direction and bidirectional does start to get more complicated. Using a bidirectional buffer such as a 74AHCT245 will work for TTL translation when going from 3.3V back to 5V providing there is a direction control signal present.

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