Author: Dan Maloney

3367 Articles

The Blood Factory: New Research May Open The Door To Artificial Blood

November 15, 2022 by 37 Comments

There were news stories afoot this week with somewhat breathless headlines that suggested a medical breakthrough was at hand: “In a 1st, two people receive transfusions of lab-grown blood cells.” A headline like that certainly catches the eye, especially as the holidays approach and the inevitable calls for increased blood donations that always seem to happen this time of year as the supply gets pinched. Does a headline like that mean that someone is working on completely artificial blood?

As always with this sort of thing, the answer is a mixed bag. Yes, a team in the UK has transfused two patients with a small amount of lab-grown red blood cells, and it’s the first time that particular procedure has been performed. But while the headline is technically correct, the amount transfused was very small, so the day when lab-grown whole blood transfusions replace donated blood isn’t exactly here yet. But the details of what was done and why it was attempted are the really interesting part here, and it’s worth a deep dive because it does potentially point the way to a future where totally synthetic blood may be a real thing.

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Hackaday Links: November 13, 2022

November 13, 2022 by 6 Comments

Talk about playing on hard mode! The news this week was rife with stories about Palmer Luckey’s murder-modified VR headset, which ostensibly kills the wearer if their character dies in-game. The headset appears to have three shaped charges in the visor pointing right at the wearer’s frontal lobe, and would certainly do a dandy job of executing someone. In a blog post that we suspect was written with tongue planted firmly in cheek, Luckey, the co-founder of Oculus, describes that the interface from the helmet to the game is via optical sensors that watch the proceeding on the screen, and fire when a certain frequency of flashing red light is detected. He’s also talking about ways to prevent the removal of the headset once donned, in case someone wants to tickle the dragon’s tail and try to quickly rip off the headset as in-game death approaches. We’re pretty sure this isn’t serious, as Luckey himself suggested that it was more of an office art thing, but you never know what extremes a “three commas” net worth can push someone to.

There’s light at the end of the Raspberry Pi supply chain tunnel, as CEO Eben Upton announced that he foresees the Pi problems resolving completely by this time next year. Upton explains his position in the video embedded in the linked article, which is basically that the lingering effects of the pandemic should resolve themselves over the next few months, leading to normalization of inventory across all Pi models. That obviously has to be viewed with some skepticism; after all, nobody saw the supply chain issues coming in the first place, and there certainly could be another black swan event waiting for us that might cause a repeat performance. But it’s good to hear his optimism, as well as his vision for the future now that we’re at the ten-year anniversary of the first Pi’s release.

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Protect Your Property With This Fire-Breathing Billionaire

November 12, 2022 by 16 Comments

Let’s face it: if you can’t trust a fire-breathing billionaire industrialist to protect your stuff, who can you trust? (Video, embedded below.)

This one is straight out of the Really Bad Ideas™ files, and comes to us from [Marc Radinovic]. His story on this one is that he wants to protect the stuff in his new house, and felt that a face-recognition system with a flame thrower would be the best way to address that. And to somehow make it even better, said system would be built into a ridiculous portrait of everyone’s favorite plutocrat. The guts of the system are pretty much what you’d expect — a camera and a Raspberry Pi running OpenCV and a face recognition library, a butane reservoir and a solenoid valve, an arc lighter as an ignition source, and an Arduino and some completely not sketchy at all wiring to control all pieces. And LCD displays for [Elon]’s eyes, of course.

The system is trained to recognize [Marc]’s face and greets him cheerfully when he’s in view. [Non-Marc] people, however, are treated a bit less accommodatingly, up to and including a face-melting fireball. Effigies of other billionaires got the treatment; strangely, [Marc]’s face-recognition algorithm didn’t even recognize another [Mark] as a human face, which when you think about it is pretty darn funny.

So, certainly not a practical security system, and definitely not something you should build, but it’s pretty good fun anyway. It reminds us a bit of the fire-breathing duck we saw years ago.

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Bringing Up An Old Motherboard Is A Delicate Process

November 12, 2022 by 12 Comments

If you were around for the early days of the personal computer revolution, you’ll no doubt recall the excitement every time IBM announced a new version of its beige boxes. For a lot of us, the excitement was purely vicarious, for despite the “personal” moniker, mere mortals could rarely afford a branded IBM machine. But it was still cool to keep track of the latest releases, and dream of the days when cheap clones would make it possible to play.

[Anders Nielsen]’s recent find of an original IBM Model 5160 motherboard sort of echoes that long-ago excitement, but in a different way. This board, from a PC XT built in 1984, was in unknown condition upon arrival, so [Anders] set about a careful process to try to bring the board back to life. A quick visual inspection leaves one with a sense of both how much things have changed, and how much they’ve stayed the same. Aside from the big 40-pin DIP 8088 CPU and the BIOS ROMs, the board is almost completely populated with discrete logic chips, but at the same time, the basic footprint of a motherboard has changed very little.

The bring-up process in the video below includes checks of all the power rails for shorts, which ended up being a good call — drat those tantalums. After fixing that issue, [Anders] had a bit of trouble getting the board to POST, and eventually resorted to dumping the BIOS ROMs and inspecting the contents. One of the chips had picked up a case of the scramblies at some point, which was easy enough to fix thanks to images of the 5160 ROMs available online. We thought the trick of using a 64k ROM and just writing the BIOS image twice was pretty clever.

In the end, the board came up, although without video or keyboard — that’s for another day. Can’t find your own PC XT motherboard to play with? Then maybe you can just build one.

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3D Printer Repurposed For Light-Duty Lab Automation Tasks

November 11, 2022 by 3 Comments

Laboratory automation equipment is expensive stuff, to such a degree that small labs are often priced out of the market. That’s a shame, because there are a lot of tedious manual tasks that even modest labs would benefit from automating. Oh well — that’s what grad students are for.

But it actually isn’t that hard to bring a little automation to the lab, if you follow the lead of [Marco], [Chinna], and [Vittorio] and turn a 3D printer into a simple lab robot. That’s what HistoEnder is — a bog-standard Creality Ender 3 with a couple of special modifications that turn it into a tool for automating histology slide preparation. Histology is the study of the anatomy of tissues and uses various fixing and staining techniques to make microscopic features visible. In practice, this means moving baskets of glass slides back and forth between jars of different solutions, a job that’s perfect for a simple Cartesian gantry lab robot with a small work envelope and light loads.

None of the printer modifications are permanent; the 3D printed accessories — a hook for the slide basket and a carrier for standard histology staining jars — can quickly come off the printer to return it to its regular duty. All it takes to run HistoEnder is a bit of custom G-code and some careful alignment of the jar carrier on the print bed. We suppose the bed heater could even be used to warm up the fixing and staining solutions. There’s a brief video of HistoEnder in action embedded in the tweet below.

This isn’t the first time this team has repurposed technology for the lab — remember the fitness band that was turned into an optical densitometer?

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Clever Control Loop Makes This Spinning Drone Fault-Tolerant

November 9, 2022 by 18 Comments

Most multi-rotor aircraft are about as aerodynamic as a brick. Unless all its motors are turning and the control electronics are doing their thing, most UAVs are quickly destined to become UGVs, and generally in spectacular fashion. But by switching up things a bit, it’s possible to make a multi-rotor drone that keeps on flying even without two-thirds of its motors running.

We’ve been keeping a close eye on [Nick Rehm]’s cool spinning drone project, which basically eschews a rigid airframe for a set of three airfoils joined to a central hub. The collective pitch of the blades can be controlled via a servo in the hub, and the whole thing can be made to rotate and provide lift thanks to the thrust of tip-mounted motors and props. We’ve seen [Nick] manage to get this contraption airborne, and hovering is pretty straightforward. The video below covers the next step: getting pitch, roll, and yaw control over the spinning blades of doom.

The problem isn’t trivial. First off, [Nick] had to decide what the front of a spinning aircraft even means. Through the clever uses of LED strips mounted to the airfoils and some POV magic, he was able to visually indicate a reference axis. From there he was able to come up with a scheme to vary the power to each motor as it moves relative to the reference axis, modulating it in either a sine or cosine function to achieve roll and pitch control. This basically imitates the cyclic pitch control of a classic helicopter — a sort of virtual swashplate.

The results of all this are impressive, if a bit terrifying. [Nick] clearly has control of the aircraft even though it’s spinning at 250 RPM, but even cooler is the bit where he kills first one then two motors. It struggles, but it’s still controllable enough for a bumpy but safe landing.

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The Wow! Signal Revisited: Citizen Science Informs SETI Effort

November 8, 2022 by 52 Comments

As far as interesting problems go, few can really compete with the perennial question: “Are we alone?” The need to know if there are other forms of intelligent life out there in the galaxy is deeply rooted, and knowing for sure either way would have massive implications.

But it’s a big galaxy, and knowing where to look for signals that might mean we’re not alone is a tough task. Devoting limited and expensive resources to randomly listen to chunks of the sky in the hopes of hearing something that’s obviously made by a technical civilization is unlikely to bear fruit. Much better would be to have something to base sensible observations on — some kind of target that has a better chance of paying off.

Luckily, a chance observation nearly 50 years ago has provided just that. The so-called Wow! Signal, much discussed but only occasionally and somewhat informally studied, has provided a guidepost in the sky, thanks in part to a citizen scientist with a passion for finding exoplanets.

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