Hacked Heating Instruments For The DIY Biology Lab

November 12, 2018 by Dan Maloney 4 Comments

[Justin] from The Thought Emporium takes on a common molecular biology problem with these homebrew heating instruments for the DIY biology lab.

The action at the molecular biology bench boils down to a few simple tasks: suck stuff, spit stuff, cool stuff, and heat stuff. Pipettes take care of the sucking and spitting, while ice buckets and refrigerators do the cooling. The heating, however, can be problematic; vessels of various sizes need to be accommodated at different, carefully controlled temperatures. It’s not uncommon to see dozens of different incubators, heat blocks, heat plates, and even walk-in environmental chambers in the typical lab, all acquired and maintained at great cost. It’s enough to discourage any would-be biohacker from starting a lab.

[Justin] knew It doesn’t need to be that way, though. So he tackled two common devices: the incubator and the heating block. The build used as many off-the-shelf components as possible, keeping costs down. The incubator is dead simple: an insulated plastic picnic cooler with a thermostatically controlled reptile heating pad. That proves to be more than serviceable up to 40°, at the high end of what most yeast and bacterial cultures require.

The heat block, used to heat small plastic reaction vessels called Eppendorf tubes, was a little more complicated to construct. Scrap heat sinks yielded aluminum stock, which despite going through a bit of a machinist’s nightmare on the drill press came out surprisingly nice. Heat for the block is provided by a commercial Peltier module and controller; it looks good up to 42°, a common temperature for heat-shocking yeast and tricking them into taking up foreign DNA.

We’re impressed with how cheaply [Justin] was able to throw together these instruments, and we’re looking forward to seeing how he utilizes them. He’s already biohacked himself, so seeing what happens to yeast and bacteria in his DIY lab should be interesting.

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I Hear You Offer WiFi

September 22, 2018 by Brian McEvoy 13 Comments

We are swimming in radio transmissions from all around, and if you live above the ground floor, they are coming at you from below as well. Humans do not have a sensory organ for recognizing radio signals, but we have lots of hardware which can make sense of it. The chances are good that you are looking at one such device right now. [Frank Swain] has leaped from merely accepting the omnipresent signals from WiFi routers and portable devices to listening in on them. The audio signals are mere soundwaves, so he is not listening to every tweet and email password, merely a representation of the data’s presence. There is a sample below the break, and it sounds like a Geiger counter playing PIN•BOT.

We experience only the most minuscule sliver of information coming at us at any given moment. Machines to hack that gap are not had to find on these pages so [Frank] is in good company. Magnetosensory is a popular choice for people with a poor sense of direction. Echolocation is perfect for fans of Daredevil. Delivering new sensations could be easier than ever with high-resolution tactile displays. Detect some rather intimate data with ‘SHE BON.’

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Cat Robot’s Secret To Slim Legs? Banish The Motors!

September 15, 2018 by Donald Papp 6 Comments

The first thing to notice about [Bijuo]’s cat-sized quadruped robot designs (link is in Korean, Google translation here) is how slim and sleek the legs are. That’s because unlike most legged robots, the limbs themselves don’t contain any motors. Instead, the motors are in the main body, with one driving a half-circle pulley while another moves the limb as a whole. Power is transferred by a cable acting as a tendon and is offset by spring tension in the joints. The result is light, slim legs that lift and move in a remarkable gait.

[Bijuo] credits the Cheetah_Cub project as their original inspiration, and names their own variation Mini Serval, on account of the ears and in keeping with the feline nomenclature. Embedded below are two videos, the first showing leg and gait detail, and the second demonstrating the robot in motion.

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Micro-Organisms Give Up The Volts In This Biological Battery

July 27, 2018 by Donald Papp 18 Comments

Battery cells work by chemical reactions, and the fascinating Hybrid Microbial Fuel Cell design by [Josh Starnes] is no different. True, batteries don’t normally contain life, but the process coughs up useful electrons all the same; 1.7 V per cell in [Josh]’s design, to be precise. His proof of concept consists of eight cells in parallel, enough to give his cell phone a charge via a DC-DC boost converter. He says it’s not known how long this can be expected to last before the voltage drops to an unusable level, but it works!

Eight-cell, 3D printed proof of concept.

There are two complementary sides to each cell in [Josh]’s design. On the cathode side are phytoplankton; green micro algae that absorb carbon dioxide and sunlight. On the anode side are bacteria that break organic material (like food waste) into nitrates, and expel carbon dioxide. Version 2 of the design will incorporate a semi-permeable membrane between the cells that would allow oxygen and carbon dioxide to be exchanged while keeping the populations of micro-organisms separate; this would make the biological processes more complementary.

A battery consisting of 24 cells and a plumbing system to cycle and care for the algae and bacteria is the ultimate goal, and we hope [Josh] can get closer to that now that his project won a $1000 cash prize as one of the twenty finalists in the Power Harvesting Challenge portion of the Hackaday Prize. (Next up is the Human Computer Interface Challenge, just so you know.)

Reverse-Engineering Brains, One Neuron At A Time

June 30, 2018 by Roger Cheng 10 Comments

Most posts here are electrical or mechanical, with a few scattered hacks from other fields. Those who also keep up with advances in biomedical research may have noticed certain areas are starting to parallel the electronics we know. [Dr. Rajib Shubert] is in one such field, and picked up on the commonality as well. He thought it’d be interesting to bridge the two worlds by explaining his research using analogies familiar to the Hackaday audience. (Video also embedded below.)

He laid the foundation with a little background, establishing that we’ve been able to see individual static neurons for a while via microscope slides and such, and we’ve been able to see activity of the whole living brain via functional MRI. These methods gradually improved our understanding of neurons, and advances within the past few years have reached an intersection of those two points: [Dr. Shubert] and colleagues now have tools to peer inside a functional brain, teasing out how it works one neuron at a time.

[Dr. Shubert]’s talk makes analogies to electronics hardware, but we can also make a software analogy treating the brain as a highly optimized (and/or obfuscated) piece of code. Virus stamping a single cell under this analogy is like isolating a single function, seeing who calls it, and who it calls. This pairs well with optogenetics techniques, which can be seen as like modifying a function to see how it affects results in real time. It certainly puts a different meaning on the phrase “working with live code”!

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Plant Biology Is A Gateway

May 23, 2018 by Brian McEvoy 7 Comments

Too many college students have been subject to teachers’ aids who think they are too clever to be stuck teaching mere underclassmen. For that reason, [The Thought Emporium] is important because he approaches learning with gusto and is always ready to learn something new himself and teach anyone who wants to learn. When he released a video about staining and observing plant samples, he avoided the biggest pitfalls often seen in college or high school labs. Instead of calling out the steps by rote, he walks us through them with useful camera angles and close-ups. Rather than just pointing at a bottle and saying, “the blue one,” he tells us what is inside and why it is essential. Instead of telling us precisely what we need to see to get a passing grade, he lets our minds wonder about what we might see and shows us examples that make the experiment seem exciting. The video can also be seen below the break.

The process of staining can be found in a biology textbook, and some people learn best by reading, but we haven’t read a manual that makes a rudimentary lab seem like the wardrobe to Narnia, so he gets credit for that. Admittedly, you have to handle a wicked sharp razor, and the chance of failure is never zero. In fact, he will tell you, the opportunities to fail are everywhere. The road to science isn’t freshly paved, it needs pavers.

If a biology lab isn’t in your personal budget, a hackerspace may have one or need one. If you are wondering where you’ve heard [The Thought Emporium]’s voice before, it is because he is fighting lactose intolerance like a hacker.

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Modular Blocks Help Fight Disease

May 18, 2018 by Bryan Cockfield 3 Comments

When engineering a solution to a problem, an often-successful approach is to keep the design as simple as possible. Simple things are easier to produce, maintain, and use. Whether you’re building a robot, operating system, or automobile, this type of design can help in many different ways. Now, researchers at MIT’s Little Devices Lab have taken this philosophy to testing for various medical conditions, using a set of modular blocks.

Each block is designed for a specific purpose, and can be linked together with other blocks. For example, one block may be able to identify Zika virus, and another block could help determine blood sugar levels. By linking the blocks together, a healthcare worker can build a diagnosis system catered specifically for their needs. The price tag for these small, simple blocks is modest as well: about $0.015, or one and a half cents per block. They also don’t need to be refrigerated or handled specially, and some can be reused.

This is an impressive breakthrough that is poised to help not only low-income people around the world, but anyone with a need for quick, accurate medical diagnoses at a marginal cost. Keeping things simple and modular allows for all kinds of possibilities, as we recently covered in the world of robotics.

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