It’s fair to say that there’s really no phase of spaceflight that could be considered easy. But the case could be made that the most difficult part of a spacecraft’s journey is right at the very beginning, within the first few minutes of flight. At this point the vehicle’s booster rocket will be fighting with all its might against its own immense propellant-laden mass, a battle that it’s been engineered to win by the smallest of margins. Assuming the balance was struck properly and the vehicle makes its way off of the launch pad, it will still need to contend with the thick sea-level atmosphere as it accelerates, a building dynamic pressure that culminates with a point known as “Max q” — the moment where the air density imposes the maximum structural load on the rocket before quickly dropping off as the vehicle continues to ascend and the atmosphere thins.
While the vast majority of rocket launches have to contend with the realities of flying through the lower atmosphere, there are some exceptions. By launching a rocket from an aircraft, it can avoid having to power itself up from sea level. This allows the rocket to be smaller and lighter, as it doesn’t require as much propellant nor do its engines need to be as powerful.
The downside of this approach however is that even a relatively small rocket needs a very large aircraft to carry it. For example, Virgin Orbit’s LauncherOne rocket must be carried to launch altitude by a Boeing 747-400 airliner in order to place a 500 kg (1,100 lb) payload into orbit.
But what if there was another way? What if you could get all the benefits of starting your rocket from a higher altitude, without the cost and logistical issues involved in carrying it with a massive airplane? It might sound impossible, but the answer is actually quite simple…all you have to do it throw it hard enough.
Throughout this two-year global COVID-19 nightmare, one thing that has been sorely lacking is access to testing. “Flu-like symptoms” covers a lot of ground, and knowing if a sore throat is just a sore throat or something more is important enough that we’ve collectively plowed billions into testing. Unfortunately, the testing infrastructure remains unevenly distributed, which is a problem this backpack SARS-CoV-2 testing lab aims to address.
The portable lab, developed by [E. Emily Lin] and colleagues at the Queen Mary University of London, uses a technique called LAMP, for loop-mediated isothermal amplification. LAMP probably deserves an article of its own to explain the process, but suffice it to say that like PCR, LAMP amplifies nucleic acid sequences, but does so without the need for expensive thermal cycling equipment. The kit contains a microcentrifuge that’s fashioned from an e-waste hard drive, a 3D printed rotor, and an Arduino to drive the motor and control the speed. The centrifuge is designed to run on any 12 VDC source, meaning the lab can be powered by a car battery or solar panel if necessary. Readout relies on the trusty Mark I eyeball and a pH-indicating buffer that changes color depending on how much SARS-CoV-2 virus was in the sample.
The International Space Station is humanity’s most expensive gym membership.
Since the earliest days of human spaceflight, it’s been understood that longer trips away from Earth’s gravity can have a detrimental effect on an astronaut’s body. Floating weightless invariably leads to significantly reduced muscle mass in the same way that a patient’s muscles can atrophy if they spend too much time laying in bed. With no gravity to constantly fight against, an astronauts legs, back, and neck muscles will weaken from disuse in as little as a week. While this may not pose an immediate problem during spaceflight, astronauts landing back on Earth in this physically diminished state are at a higher risk of injury.
Luckily this problem can be largely mitigated with rigorous exercise, and any orbiting vessel spacious enough to hold human occupants for weeks or months will by necessity have enough internal volume to outfit it with basic exercise equipment such as a treadmill or a resistance machine. In practice, every space station since the Soviet Union’s Salyut 1 in 1971 has featured some way for its occupants to workout while in orbit. It’s no replacement for being on Earth, as astronauts still return home weaker than when they left, but it’s proven to be the most practical approach to combating the debilitating aspects of long duration spaceflight.
Of course, there’s an obvious problem with this: every hour spent exercising in space is an hour that could be better spent doing research or performing maintenance on the spacecraft. Given the incredible cost of not just putting a human into orbit, but keeping them there long-term, time is very literally money. Which brings us back to my original point: astronauts spending two or more hours each day on the International Space Station’s various pieces of exercise equipment just to stave off muscle loss make it the world’s most expensive gym membership.
The ideal solution, it’s been argued, is to design future spacecraft with the ability to impart some degree of artificial gravity on its passengers through centripetal force. The technique is simple enough: just rotate the craft along its axis and the crew will “stick” to the inside of the hull. Unfortunately, simulating Earth-like gravity in this way would require the vessel to either be far larger than anything humanity has ever launched into space, or rotate at a dangerously high speed. That’s a lot of risk to take on for what’s ultimately just a theory.
But a recent paper from the University of Tsukuba in Japan may represent the first real steps towards the development of practical artificial gravity systems aboard crewed spacecraft. While their study focused on mice rather than humans, the results should go a long way to codifying what until now was largely the stuff of science fiction.
Most of us can say that we have taken an obsolete hard drive out of a computer and felt it was a waste to toss it in the e-waste pile. Some of us have children’s drawings hung on the fridge with actuator magnets, or maybe a vast spreadsheet suspended on a steel filing cabinet. Let us not forget that there is also a high-speed, low-noise motor in there. On some models it is separate from the PCB, so grab an Electronic Speed Controller (ESC), your microcontroller of choice, and make yourself a salvaged HDD centrifuge like [Cave Man] has. His build uses the tray as a chassis, but he modeled and printed a new face in the same style as the original.
On top, he has an OLED screen for displaying the requested speed, measured speed, and runtime. Next to the display is a four-button pad with a customized legend for setting parameters. The video after the break shows the machine running through its paces. This version accommodates the tiny capillary tubes, microhematocrit tubes, for processing raw blood. This test can calculate the packed cell volume, which professionals use to determine things from dehydration to anemia.
There are other builds out there where people have modified an old drive into the kind of centrifuge that accepts larger diameter tubes, but this was a shining example of what is possible. One good turn deserves another, so we recommend a desktop bio-lab companion, or enlist some LEGO Mindstorms to help out.
It was early 1983 and Françoise Barré-Sinoussi of the prestigious Pasteur Institute in Paris was busy at the centrifuge trying to detect the presence of a retrovirus. The sample in the centrifuge came from an AIDS patient, though the disease wasn’t called AIDS yet.
Just two years earlier in the US, a cluster of young men had been reported as suffering from unusual infections and forms of cancer normally experienced by the very old or by people using drugs designed to suppress the immune system. More cases were reported and US Centers for Disease Control and Prevention (CDC) formed a task force to monitor the unusual outbreak. In December, the first scientific article about the outbreak was published in the New England Journal of Medicine.
By May 1983, researchers Barré-Sinoussi and Luc Montagnier of the Pasteur Institute had isolated HIV, the virus which causes AIDS, and reported it in the journal Science. Both received the Nobel prize in 2008 for this work and the Nobel prize citation stated:
Never before have science and medicine been so quick to discover, identify the origin and provide treatment for a new disease entity.
It’s only fitting then that we take a closer look at one of these modern detectives of science, Françoise Barré-Sinoussi, and what led to her discovery.
Centrifuges are vital to the study of medicine, chemistry, and biology. They’re vital tools to separate the wheat from the chaff figuratively, and DNA from saliva literally. Now, they’re fidget spinners. [Matlek] designed a fidget spinner that also functions as a simple lab centrifuge.
The centrifuge was designed in Fusion 360, and was apparently as easy as drawing a few circles and hitting copy and paste. Interestingly, this fidget spinner was designed to be completely 3D printable, including the bearings. The bearing is a standard 608 though, so if you want to get some real performance out of this centrispinner, off-the-shelf bearings are always an option. The design of this fidget spinner holds 2 mL and 1.5 mL vials, but if your lab has 500 μL tubes on hand, there are handy 3D printable adapters.
Still think using a toy to do Real Science™ is dumb? Contain your rage, because a few months ago a few folks at Stanford devised a way to build a centrifuge out of paper. This paperfuge can — at least theoretically — save lives where real commercial centrifuges or even electricity aren’t available. Fidget spinners save humanity once again.
The centrifuge was designed in Sketch-Up and then 3D printed. They note to take extra care to get high quality 3D prints so that the rotor isn’t out of balance. To get the high speeds needed for the extraction, they use a brushless motor from a quadcopter. This is combined with an Arduino and an ESC. There are full assembly instructions on Thingiverse.
[F.Lab] has some other DIY lab equipment designs, such as this magnetic stirrer. Which we assume you could use to make a shot if you wanted to. However, it’s probably not a good idea to mix lab supplies and food surfaces. Video after the break.