Building A DIY Centrifuge For Blood Processing

September 17, 2026 by Zoe Skyforest 19 Comments

If you want to do certain types of lab work with blood, you’ll need a centrifuge. It’s often possible to find serviceable units on the used market, but they may not meet your requirements if you’re doing something quite specific. For that reason, [Thomas Nguyen] decided to build his own centrifuge from scratch.

His goal was to separate T cells from blood for further lab analysis, and he needed to be able to work with blood in 15 mL conical tubes. Capable centrifuges weren’t affordable, but he figured he could build his own quite easily. To that end, he enlisted a Raspberry Pi Pico, a 3D printer, and an A2212 brushless motor with a 30 amp electronic speed controller.

Soon enough, he had a design for a fixed-angle centrifuge design that could spin up blood products to the required speed for separation. It has useful safety features, like an MPU-6050 for vibration detection to shut down in case of dangerous imbalance, and an IR sensor for monitoring and controlling rotational speed. For now, the project is still in development, with the first version built and spinning. [Thomas] aims to check that the build operates safely and can separate fluids like dyed water and glycerol successfully before running it with real blood products.

We’ve seen other successful DIY centrifuge builds before, too. Sometimes, the lab hardware you need is the lab hardware you build yourself. If it works and does the job safely, it can be all that you need to get your science goals coming to fruition.

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Most Extreme Hypergravity Facility Starts Up In China With 1,900 Times Earth’s Gravity

November 19, 2024 by Maya Posch 33 Comments

The schematic diagram of the experimental centrifuge. (Credit: Jianyong Liu et al., 2024)

Recently China’s new CHIEF hypergravity facility came online to begin research projects after beginning construction in 2018. Standing for Centrifugal Hypergravity and Interdisciplinary Experiment Facility the name covers basically what it is about: using centrifuges immense acceleration can be generated. With gravity defined as an acceleration on Earth of 1 g, hypergravity is thus a force of gravity >1 g. This is distinct from simple pressure as in e.g. a hydraulic press, as gravitational acceleration directly affects the object and defines characteristics such as its effective mass. This is highly relevant for many disciplines, including space flight, deep ocean exploration, materials science and aeronautics.

While humans can take a g-force (g₀) of about 9 g₀ (88 m/s²) sustained in the case of trained fighter pilots, the acceleration generated by CHIEF’s two centrifuges is significantly above that, able to reach hundreds of g. For details of these centrifuges, this preprint article by [Jianyong Liu] et al. from April 2024 shows the construction of these centrifuges and the engineering that goes into their operation, especially the aerodynamic characteristics. Both air pressure (30 – 101 kPa) and arm velocity (200 – 1000 g) are considered, with the risks being overpressure and resonance, which if not designed for can obliterate such a centrifuge.

The acceleration of CHIEF is said to max out at 1,900 gravity tons (gt, weight of one ton due to gravity), which is significantly more than the 1,200 gt of the US Army Corps of Engineers’ hypergravity facility.

Hackaday Links: January 7, 2024

January 7, 2024 by Dan Maloney 27 Comments

Oh, perfect — now our cars can BSOD. At least that’s how it looks from a forum post showing a Blue Screen of Death on a Ford Mustang Mach E, warning that an over-the-air software update failed, and now the car can’t be driven. The BSOD includes a phone number to reach Ford’s Customer Relationship Center and even presents a wall of text with specific instructions to the wrecker driver for loading the bricked vehicle onto a flatbed. Forum users questioned the photo’s veracity, but there are reports of other drivers getting bricked the same way. And we’ve got to point out that even though this specific bricking happened to an EV, it could just have easily happened to an ICE vehicle too; forum members were particularly prickly about that point. It would be nice if OTA software updates on vehicles could always roll back to the previous driveable state. Still, we suppose that’s not always possible, especially if memory gets corrupted during the update. Maybe the best defense against a bricked vehicle would be to keep a beater around that doesn’t need updates to keep running.

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High School Student Builds Inexpensive Centrifuge

July 11, 2023 by Bryan Cockfield 31 Comments

Having a chemistry lab fully stocked with all necessary equipment is the dream of students, teachers, and professors alike, but a lot of that equipment can be prohibitively expensive. Even in universities, labs are often left using old or worn-out equipment due to cost. So one could imagine that in high schools this is even a more pronounced problem. High school student [Aidan Miller] has solved this problem with at least one piece of lab equipment, bringing the cost for a centrifuge down to around $10 USD.

Part of the savings is due to the fact that [Aidan] has put together a smaller sized centrifuge, known as a micro-centrifuge. The function is still the same though, spinning samples to separate them out the constituents by weight. The 3D printed base of the centrifuge houses a switch and 9 V battery and also holds a small motor which spins the rotor. The rotor itself is also 3D printed, and needed to be a very specific shape to ensure that it could hold the samples properly at high RPM and maintain reasonable balance while spinning.

As a project it’s fairly simple and straightforward to build, but the more impressive thing here is how much it brings down the cost of lab equipment especially for high school labs that might otherwise struggle for funding. Of course it requires the use of a 3D printer but the costs of those have been coming down significantly as well, especially for things like this portable 3D printer which was also built by a high school student.

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SpinLaunch And The History Of Hurling Stuff Into Space

June 24, 2022 by Tom Nardi 156 Comments

It’s fair to say that there’s really no phase of spaceflight that could be considered easy. But the case could be made that the most difficult part of a spacecraft’s journey is right at the very beginning, within the first few minutes of flight. At this point the vehicle’s booster rocket will be fighting with all its might against its own immense propellant-laden mass, a battle that it’s been engineered to win by the smallest of margins. Assuming the balance was struck properly and the vehicle makes its way off of the launch pad, it will still need to contend with the thick sea-level atmosphere as it accelerates, a building dynamic pressure that culminates with a point known as “Max q” — the moment where the air density imposes the maximum structural load on the rocket before quickly dropping off as the vehicle continues to ascend and the atmosphere thins.

Air-launched rockets avoid flying through dense sea level air.

While the vast majority of rocket launches have to contend with the realities of flying through the lower atmosphere, there are some exceptions. By launching a rocket from an aircraft, it can avoid having to power itself up from sea level. This allows the rocket to be smaller and lighter, as it doesn’t require as much propellant nor do its engines need to be as powerful.

The downside of this approach however is that even a relatively small rocket needs a very large aircraft to carry it. For example, Virgin Orbit’s LauncherOne rocket must be carried to launch altitude by a Boeing 747-400 airliner in order to place a 500 kg (1,100 lb) payload into orbit.

But what if there was another way? What if you could get all the benefits of starting your rocket from a higher altitude, without the cost and logistical issues involved in carrying it with a massive airplane? It might sound impossible, but the answer is actually quite simple…all you have to do it throw it hard enough.

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HDD Centrifuge Puts COVID-19 Testing Lab In A Backpack

February 5, 2022 by Dan Maloney 11 Comments

Throughout this two-year global COVID-19 nightmare, one thing that has been sorely lacking is access to testing. “Flu-like symptoms” covers a lot of ground, and knowing if a sore throat is just a sore throat or something more is important enough that we’ve collectively plowed billions into testing. Unfortunately, the testing infrastructure remains unevenly distributed, which is a problem this backpack SARS-CoV-2 testing lab aims to address.

The portable lab, developed by [E. Emily Lin] and colleagues at the Queen Mary University of London, uses a technique called LAMP, for loop-mediated isothermal amplification. LAMP probably deserves an article of its own to explain the process, but suffice it to say that like PCR, LAMP amplifies nucleic acid sequences, but does so without the need for expensive thermal cycling equipment. The kit contains a microcentrifuge that’s fashioned from an e-waste hard drive, a 3D printed rotor, and an Arduino to drive the motor and control the speed. The centrifuge is designed to run on any 12 VDC source, meaning the lab can be powered by a car battery or solar panel if necessary. Readout relies on the trusty Mark I eyeball and a pH-indicating buffer that changes color depending on how much SARS-CoV-2 virus was in the sample.

Granted, the method used here still requires more skill to perform than a simple “spit on a stick” rapid antigen test, and it’s somewhat more subjective than the “gold standard” quantitative polymerase chain reaction (qPCR) assay. But the method is easily learned, and the kit’s portability, simple design, and low-cost construction could make it an important tool in attacking this pandemic, or the next one.

Thanks to [Christian Himmler] for the tip.

ISS Artificial Gravity Study Shows Promise For Long Duration Spaceflight

June 8, 2021 by Tom Nardi 105 Comments

The International Space Station is humanity’s most expensive gym membership.

Since the earliest days of human spaceflight, it’s been understood that longer trips away from Earth’s gravity can have a detrimental effect on an astronaut’s body. Floating weightless invariably leads to significantly reduced muscle mass in the same way that a patient’s muscles can atrophy if they spend too much time laying in bed. With no gravity to constantly fight against, an astronauts legs, back, and neck muscles will weaken from disuse in as little as a week. While this may not pose an immediate problem during spaceflight, astronauts landing back on Earth in this physically diminished state are at a higher risk of injury.

Luckily this problem can be largely mitigated with rigorous exercise, and any orbiting vessel spacious enough to hold human occupants for weeks or months will by necessity have enough internal volume to outfit it with basic exercise equipment such as a treadmill or a resistance machine. In practice, every space station since the Soviet Union’s Salyut 1 in 1971 has featured some way for its occupants to workout while in orbit. It’s no replacement for being on Earth, as astronauts still return home weaker than when they left, but it’s proven to be the most practical approach to combating the debilitating aspects of long duration spaceflight.

Early NASA concept for creating artificial gravity.

Of course, there’s an obvious problem with this: every hour spent exercising in space is an hour that could be better spent doing research or performing maintenance on the spacecraft. Given the incredible cost of not just putting a human into orbit, but keeping them there long-term, time is very literally money. Which brings us back to my original point: astronauts spending two or more hours each day on the International Space Station’s various pieces of exercise equipment just to stave off muscle loss make it the world’s most expensive gym membership.

The ideal solution, it’s been argued, is to design future spacecraft with the ability to impart some degree of artificial gravity on its passengers through centripetal force. The technique is simple enough: just rotate the craft along its axis and the crew will “stick” to the inside of the hull. Unfortunately, simulating Earth-like gravity in this way would require the vessel to either be far larger than anything humanity has ever launched into space, or rotate at a dangerously high speed. That’s a lot of risk to take on for what’s ultimately just a theory.

But a recent paper from the University of Tsukuba in Japan may represent the first real steps towards the development of practical artificial gravity systems aboard crewed spacecraft. While their study focused on mice rather than humans, the results should go a long way to codifying what until now was largely the stuff of science fiction.

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