Building An Electron Microscope For Research

There are a lot of situations where a research group may turn to an electron microscope to get information about whatever system they might be studying. Assessing the structure of a virus or protein, analyzing the morphology of a new nanoparticle, or examining the layout of a semiconductor all might require the use of one of these devices. But if your research involves the electron microscope itself, you might be a little more reluctant to tear down these expensive devices to take a look behind the curtain as the costs to do this for more than a few could quickly get out of hand. That’s why this research group has created their own electron detector.

Specifically, the electron detector is designed for use in a scanning electron microscope, which is typically used for inspecting the surface of a sample and retrieving a high-resolution, 3D image of it compared to transmission microscopes which can probe internal structures. The detector is built on a four-layer PCB which includes the photodiode sensing array, a series of amplifiers, and a power supply. All of the circuit diagrams and schematics are available for inspection as well thanks to the design being licensed under the open Creative Commons license. For any research team looking to build this, a bill of materials is also included, as is a set of build instructions.

While this is only one piece of the puzzle surrounding the setup and operation of an electron microscope, its arguably the most important, and also greatly lowers the barrier of entry for anyone looking to analyze electron microscope design themselves. With an open standard, anyone is free to modify or augment this design as they see fit which is a marked improvement over the closed and expensive proprietary microscopes out there. And, if low-cost microscopes are your thing be sure to check out this fluorescence microscope we featured that uses readily-available parts to dramatically lower the cost compared to commercial offerings.

Arbitrary Code Execution Over Radio

Computers connected to networks are constantly threatened by attackers who seek to exploit vulnerabilities wherever they can find them. This risk is particularly high for machines connected to the Internet, but any network connection can be susceptible to attacks. As highlighted by security researcher and consultant [Rick Osgood], even computers connected to nothing more than a radio can be vulnerable to attacks if they’re using certain digital modes of communication.

The vulnerability that [Rick] found involves exploiting a flaw in a piece of software called WinAPRS. APRS is a method commonly used in the amateur radio community for sending data over radio, and WinAPRS allows for this functionality on a PC. He specifically sought out this program for vulnerabilities since it is closed-source and hasn’t been updated since 2013. After some analysis, he found a memory bug which was used to manipulate the Extended Instruction Pointer (EIP) register which stores the memory address of the next instruction to be executed by the CPU. This essentially allows for arbitrary code execution on a remote machine via radio.

The exploit was found while using Windows XP because it lacks some of the more modern memory protection features of modern operating systems, but the exploit does still work with Windows 10, just not as reliably and with a bit of extra effort required. It’s a good reminder to use open-source software when possible so issues like these can get resolved, and to regularly install security updates when possible. If you’re looking to delve into the world of APRS in more modern times, take a look at this project which adds APRS to budget transceivers. Just make sure you get your license first.

One Method For Removing Future Space Junk

When sending satellites into space, the idea is to place them into as stable an orbit as possible in order to maximize both the time the satellite is useful and the economics of sending it there in the first place. This tends to become rather untenable as the amount of space junk continues to pile up for all but the lowest of orbits, but a team at Brown University recently tested a satellite that might help solve this problem, at least for future satellite deployments.

The main test of this satellite was its drag sail, which increases its atmospheric drag significantly and reduces its spaceflight time to around five years. This might make it seem like a problem from an economics standpoint, as it’s quite expensive to build satellites and launch them into space, but this satellite solves these problems by being both extremely small to minimize launch costs, and also by being built out of off-the-shelf components not typically rated for spaceflight. For example, it gets its power solely from AA batteries and uses an Arduino for its operation and other research.

The satellite is currently in orbit, and has already descended from an altitude of 520 km to 470 km. While it won’t help reduce the existing amount of debris in orbit, the research team hopes to demonstrate that small satellites can be affordable and economically feasible without further contributing to the growing problem of space junk. If you’re looking to launch your own CubeSat one day, take a look at this primer which goes over most of the basics.

Mice Play In VR

Virtual Reality always seemed like a technology just out of reach, much like nuclear fusion, the flying car, or Linux on the desktop. It seems to be gaining steam in the last five years or so, though, with successful video games from a number of companies as well as plenty of other virtual reality adjacent technology that seems to be picking up steam as well like augmented reality. Another sign that this technology might be here to stay is this virtual reality headset made for mice. Continue reading “Mice Play In VR”

A cartoon vehicle is connected to two wires. One is connected to an illustrated Li anode and the other to a γ-sulfur/carbon nanofiber electrode. Lithium ions and organic carbonate representations float between the two electrodes below the car. A red dotted line between the electrodes symbolizes the separator.

Lithium Sulfur Battery Cycle Life Gets A Boost

Lithium sulfur batteries are often touted as the next major chemistry for electric vehicle applications, if only their cycle life wasn’t so short. But that might be changing soon, as a group of researchers at Drexel University has developed a sulfur cathode capable of more than 4000 cycles.

Most research into the Li-S couple has used volatile ether electrolytes which severely limit the possible commercialization of the technology. The team at Drexel was able to use a carbonate electrolyte like those already well-explored for more traditional Li-ion cells by using a stabilized monoclinic γ-sulfur deposited on carbon nanofibers.

The process to create these cathodes appears less finicky than previous methods that required tight control of the porosity of the carbon host and also increases the amount of active material in the cathode by a significant margin. Analysis shows that this phase of sulfur avoids the formation of intermediate fouling polysulfides which accounts for it’s impressive cycle life. As the authors state, this is far from a commercial-ready system, but it is a major step toward the next generation of batteries.

We’ve covered the elements lithium and sulfur in depth before as well as an aluminum sulfur battery that could be big for grid storage.

Researching Factorio…For Science

Science has affirmatively answered a lot of questions that, looking back, could be seen as bizarre to have asked in the first place. Questions like “can this moldy cheese cure disease” or “can this rock perform math if we give it some electricity.”  Among the more recent of this list is the question of whether or not the video game Factorio, in which the player constructs an elaborate factory, can be used as the basis for other academic work. As [Kenneth Reid] discusses in this talk, it most certainly can.

If you haven’t played the game, it’s a sort of real-time strategy (RTS) game where the player gathers materials to construct a factory while defending it from enemies. On the surface it might seem similar to Age of Empires or Starcraft, but its complexity is taken to extremes not found in other RTS games. The complexity hides nuance, and [Kenneth] points out that it’s an excellent simulator to study real-world problems such as vehicle routing problems, decision making, artificial intelligence, bin packing problems, and production planning, among a whole slew of other interesting areas of potential research.

[Kenneth] and his partners on this project also developed some software tools with interacting with a Factorio game without having to actually play it directly. The game includes an API which the team used to develop tools so that other researchers can use it as a basis for simulations and studies. There was a research paper published as well for more in-depth reading on the topic. We shouldn’t be too surprised that a game can be used in incredibly productive ways like this, either. Here’s another example of a toy being used to train engineers working in industrial automation.

Continue reading “Researching Factorio…For Science”

New Parkinson’s Test Smells Success

Parkinson’s disease affects millions of people all over the world. The degenerative condition causes characteristic tremors, trouble walking, and often comes with complications including dementia, depression, and anxiety.

One of the major challenges around Parkinson’s disease involves diagnosis. There’s no single, commonly-available test that can confirm or rule out the disease. It’s can cause particular frustration as the disease is most treatable in its early stages.

That may soon change, however. One woman identified that she seemingly had the ability to “smell” the disease in those affected, and is now working with scientists to develop a test for the condition.

Follow Your Nose

The human sense of smell, by and large, isn’t particularly impressive. It helps us enjoy the scent of fresh bread baking in an oven, or the aroma of freshly cut grass. However, as a tool for inspecting and learning about the world around us, it really comes up short.

Some of us, though, are more capable in the olfactory department than others. Joy Milne from Perth, Scotland, is one such person. She happened to detected a change in her partner’s characteristic smell, one day, and twelve years later, they were diagnosed with Parkinson’s disease.

The idea that someone could “smell” a difference with people with Parkinson’s disease is an easy one to test. When Milne eventually put the idea together that the different smell she noticed was perhaps related to her husbands condition, she quickly drew the interest of scientists. With the aid of her partner, a former doctor, she teamed up with researchers Dr. Tilo Kunath and Professor Perdita Barran to investigate further. Continue reading “New Parkinson’s Test Smells Success”